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(St. Jude Reference #)
|Improved Human Carboxylesterase for Therapy with CPT-11 (SJ-06-0006)|
|Description||Researchers at St. Jude have generated a human carboxylesterase that efficiently activates the anticancer drug CPT-11. This was performed using site directed mutagenesis of hCE1 using information provided by the crystal structures of wildtype hCE1 and a rabbit liver CE (rCE).
Previous research developed enzyme/prodrug therapy approaches using rCE and CPT-11, this novel enzyme (hCE1mut6), would replace the rabbit protein in these studies and be much more likely to be used in any clinical application of this technology.
|Keywords||Carboxylesterase, enzyme, cancer, drug, CPT-11|
|Granted Patents or Published Applications||US 7,906,637; 8,124,393; US Pub. 2012/0142108|
|Related Scientific References||An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11”, Cancer Gene Therapy (2008) 15:183-192|
|Licensing Opportunities||We are looking for a commercial partner to license this discovery and develop, market, and sell commercial applications.|
Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.
Last update: April 2014