Arzu Onar, PhD

    Arzu Onar-Thomas, PhD

    Associate Member, St. Jude Faculty

    Departments

    Biostatistics

    Contact Information

    Arzu Onar-Thomas, PhD
    Biostatistics
    MS 768, Room R-6032
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: arzu.onar@stjude.org
    Phone: (901) 595-5499
    FAX: (901) 595-8843

    Education

    BS - University of North Carolina, Chapel Hill, NC - Mathematical Sciences (1993)
    MS - University of South Carolina, Columbia, SC - Statistics (1995)
    PhD - University of South Carolina, Columbia, SC - Statistics (1998)


    Research Interests


    Selected Publications

    Khan RB, Merchant TE, Boop FA, Sanford AA, Ledet D, Onar-Thomas A, Kun LE. Headache in children with craniopharyngioma. Journal of Child Neurology Nov 8, 2012. [Epub ahead of print]

    Blaney S, Tagen M, Onar-Thomas A, Berg S, Gururangan S, Scorsone K, Su J, Goldman S, Kieran M, Kun L, Boyett J, Stewart C. A Phase 1 Pharmacokinetic Optimal Dosing Study of Intraventricular Topotecan for Children with Neoplastic Meningitis: A Pediatric Brain Tumor Consortium Study. Pediatric Blood and Cancer 2009. doi: 10.1002/pbc.24309. [Epub ahead of print]

    Gururangan S, Fangusaro J, Poussaint T, Onar-Thomas A, Gilbertson R, Vajapeyam S, Gajjar A, Goldman S, Friedman H, Packer R, Boyett J, Kun L. Lack of efficacy of Bevacizumab plus Irinotecan in children with recurrent ependymoma – A Pediatric Brain Consortium Study. Journal of Neurooncology 14(11):1404-1412, 2012.

    Mueller S, Phillips J, Onar-Thomas A, Romero E, Zheng S, Wiencke JK, McBride SM, Cowdrey C, Prados MD, Weiss WA, Berger MS, Gupta N, Haas-Kogan DA. PTEN promoter methylation and activation of the PI3K/AKT/mTOR pathway in pediatric gliomas and influence on clinical outcome . Journal of Neurooncology 14(9):1146-52, 2012. PMID: 22753230

    Kocak M, Onar-Thomas A. A Simulation Based Evaluation of the Asymptotic Power Formulae for Cox Models in Small Sample Cases. The American Statistician 66(3):173-179, 2012.

    Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Becksfort J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. Novel mutations target distinct subgroups of medulloblastoma. Nature 488(7409):43-48. PMID: 22722829

    Jakacki RI, Burger P, Zhou T, Holmes E, Mehmet Kocak, Onar-Thomas A, Goldwein J, Mehta M, Packer R, Tarbell N, Fitz C, Vezina G, Hilden J, Pollack I. Outcome For Children with Metastatic Medulloblastoma Treated with Carboplatin During Craniospinal Radiotherapy and the Impact of Anaplasia: Results Of COG 99701. Journal of Clinical Oncology 30(21):2648-53, 2012. PMID: 22665539

    Paugh BS, Broniscer A, Qu C, Miller C, Zhang J, Tatevossian RG, Olson JM, Geyer JR, Chi S, Saba da Silva N, Onar-Thomas A, Baker J, Gajjar A, Ellison DW, Baker SJ. Genome-wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma. Journal of Clinical Oncology 29(30):3999-4006, 2011. PMID: 21931021

    Fouladi M, Stewart C, Olson J, Wagner L, Onar-Thomas A, Kocak M, Packer R, Goldman S, Gururangan S, Gajjar A, Demuth T, Kun L, Boyett JM, Gilbertson R. A Phase I Trial Of MK0752 In Children With Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study. Journal of Clinical Oncology 29(26):3529-34, 2011. PMID: 21825264

    Fortenbaugh D, Fleisig G, Onar-Thomas A, Asfour S. The Effect of Pitch Type on Ground Reaction Forces in the Baseball Swing. Sports Biomechanics 10(4): 270-279, 2011.

    Eltoukhy M, Asfour S, Onar-Thomas A. Comparison between Metallic and Allograft Knee Prosthesis Using Musculoskeletal Modeling. International Journal for Computational Vision and Biomechanics 4(1): 1-9, 2011.

    Crom DB, Smith D, Xiong Z, Onar A, Hudson MM, Merchant TE, Morris EB. Health status in long-term survivors of pediatric craniopharyngiomas. J Neurosci Nurs 42(6):323-328, 2010. PMID: 21207770

    Broniscer A, Baker J, Tagen M, Onar-Thomas A, et al. Phase I Study of Vandetanib During and After Radiotherapy in Children with Diffuse Intrinsic Pontine Glioma. Journal of Clinical Oncology 28(31): 4762-4768. PMID: 20921456

    Fouladi M, Stewart CF, Blaney SM, Onar-Thomas A, et al. A Phase I Trial of Lapatinib in Children with Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study. Journal of Clinical Oncology 28(27):4221-4227, 2010. PMID: 20713864

    Onar-Thomas A, Xiong Z. A Simulation Based Comparison of the Traditional Method, Rolling-6 Design and a Frequentist Version of the Continual Reassessment Method with Special Attention to Trial Duration in Pediatric Phase I Oncology Trials. Contemporary Clinical Trials 31(3):259-270, 2010. PMID: 20298812

    Gururangan S, Chi S, Poussaint TY, Onar-Thomas A, Gilbertson RJ, et al. Lack of Efficacy of Bevacizumab plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brain Stem Glioma - A Pediatric Brain Tumor Consortium Study (PBTC-022). Journal of Clinical Oncology 28(18):3069-75, 2010. PMID: 20479404

    Onar A, Ramamurthy U, Wallace D, Boyett JM. An operational perspective of challenging statistical dogma while establishing a modern, secure distributed data management and imaging transport system: the Pediatric Brain Tumor Consortium phase I experience. Clin Transl Sci 2(2):143-149, 2009. PMID: 20443880

    Onar A, Kocak M, Boyett JM. Modified Continual Reassessment Method versus the Traditional Empirically-Based Design for Phase I Trials in Pediatric Oncology: Experiences of the Pediatric Brain Tumor Consortium. Journal of Biopharmaceutical Statistics 19(3):437-455, 2009. PMID: 19384687

    Binsaeid S, Asfour SS, Cho S, Onar A. Machine Ensemble Approach For Simultaneous Detection of Transient and Gradual Abnormalities in End Milling Using Multi-sensor Fusion. Journal of Materials Processing Technology 209:4728-4738, 2009.

    Courey KJ, Asfour SS, Onar A, Bayliss JA, Ludwig LL, Wright MC. Tin Whisker Electrical Short Circuit Characteristics - Part II. IEEE Transactions on Electronics, Packaging and Manufacturing 32(1):41-48, 2009.

    Sanders R, Onar A, Boyett J, et al. M1 Medulloblastoma: High Risk at Any Age. Journal of Neuro-Oncology Aug 15, 2008. [Epub] PMID: 18704266

    Chakraborty P, Asfour S, Cho S, Onar A, Lynn M. Modeling tool wear progression by using mixed effects modeling technique when end-milling AISI 4340 steel,” Journal of Materials Processing Technology 205:190-202, 2008.

    Kieran M, Packer R, Onar A, et.al. Phase I and Pharmacokinetic Study of the Oral Farnesyltransferase Inhibitor Sarasar™ (Lonafarnib–SCH66336) Given Twice Daily To Pediatric Patients with Advanced Central Nervous System Tumors: A Pediatric Brain Tumor Consortium (PBTC) Study. Journal of Clinical Oncology 25(21):3137-3143, 2007. PMID: 17634493

    Onar A, Thomas F, Choubane B, Byron T. Bayesian Degradation Modeling in Accelerated Pavement Testing with Estimated Transformation Parameter for the Response. Transportation Engineering 133(12):677-687, 2007.

    Khan RB, Boop FA, Onar A, Sanford RA. Seizures in children with low grade tumors: outcome after tumor resection and risk factors for uncontrolled seizures. Journal of Neurosurgery 104:377-82, 2006. PMID: 16776371

    Onar A, Thomas F, Choubane B, Byron T. Statistical Mixed Effects Models for Evaluation and Prediction of Accelerated Pavement Testing Results. Transportation Engineering 132(10):771-780, 2006.

    Khan RB, Onar A. Seizure recurrence and risk factors after anti-epilepsy drug withdrawal in brain tumor patients. Epilepsia 47(2):375-9, 2006. PMID: 16499763

    Cho S, Asfour S, Onar A, Kaundinya N. Tool breakage detection using support vector machine learning in a milling process. International Journal of Machine Tools and Manufacture 45:241-249, 2005.

    Onar A, Padgett WJ. Cumulative Damage Approaches Leading to Inverse Gaussian Accelerated Test Models. Handbook of Statistics 23: Advances in Survival Analysis, Editors N. Balakrishnan and C. R. Rao, 2004.

    Onar A, Padgett WJ. A Penalized Local D-Optimality Approach to Design for Inverse Gaussian Accelerated Test Models. Journal of Statistical Planning and Inference 119(2):411-420, 2003.

    Onar A, Padgett WJ. Some Bayesian Procedures with the Accelerated Inverse Gaussian Distribution. Journal of Applied Statistical Science 10:191-210, 2001.

    Onar A, Padgett WJ. Accelerated Test Models with the Inverse Gaussian Distribution. Journal of Statistical Planning and Inference 89:119-133, 2000.

    Onar A, Padgett WJ. Inverse Gaussian Accelerated Test Models Based on Cumulative Damage. Journal of Statistical Computing and Simulation 64:233-247, 2000.

    Last update: February 2013