Pharmacokinetics and Medications

"Do you know ..." is an educational series for patients and their families.

After high dose methotrexate for leukemia

After receiving high dose methotrexate for leukemia, it is important that your child stays well-hydrated. She will also be given other medicines by IV for at least 2 days after receiving high dose methotrexate.

After high dose methotrexate for solid tumors

After receiving high dose methotrexate for solid tumors, it is important that your child stays well-hydrated. For this reason, your child will receive IV fluids by a portable pump for at least 3 days after receiving high dose methotrexate.

Chemotherapy by mouth at home

Oral chemotherapy (chemo) is any cancer-fighting drug that the patient will take by mouth. It can be in the form of a tablet, capsule, or liquid.

Children and teens taking antidepressants

Antidepressants are drugs used, most often, to treat depression. Depression is a complex illness that involves sad and hopeless feelings that do not go away. Read this handout to learn more about depression and the benefits and risks of taking antidepressants.

Cytochrome P450 2C19 (CYP2C19) and medicines

When you take a medicine (drug), your body has to have a way to handle the medicine. One way is for enzymes to metabolize (break down) the medicine. A family of enzymes called cytochrome P450s have the ability to break down certain medicines. CYP2C19 is one of those enzymes.

Cytochrome P450 2D6 (CYP2D6) and medicines

When you take a medicine (drug), your body has to have a way to handle the medicine. One way is for enzymes to metabolize (break down) the medicine. A family of enzymes called cytochrome P450s have the ability to break down certain medicines.

DPYD and Medicines

When you take a medicine (drug), your body has to have a way to handle the medicine. One way is for enzymes to metabolize (break down) the medicine. Dihydropyrimidine dehydrogenase (DPYD) is an enzyme that has the ability to break down a class of medicines called fluoropyrimidines.

Oral sucrose

Oral sucrose is a simple sugar solution. It can cause the body to release endorphins, which are chemicals that can help reduce pain. Oral sucrose is sometimes used to comfort infants and toddlers during procedures that could cause pain.

Oral syringes vs. IV syringes

Many times when we hear the word syringe, we think of a syringe that is used to inject medicine into the body. But, a different type of syringe is used to give medicines by mouth (oral). These syringes are a great way to measure oral liquid medicine, so each dose is accurate.

Pharmacokinetics

Pharmacokinetics is an important section of the Pharmaceutical Sciences department at St. Jude. The staff in Pharmacokinetics works hard to find out: how much, how often, how long certain medicines should be given to your child to achieve the best results.

Protecting caregivers from drug hazards

This handout provides guidelines for handling drugs that could pose a health risk to the caregiver.

SLCO1B1 and medicines

When you take a medicine (drug), your body has to have a way to handle the medicine. One way is for carriers to transport medicines. A transporter called solute carrier organic anion transporter family member 1B1 (SLCO1B1) helps the body get rid of certain medicines after they are no longer needed.

Therapy for preventing blood clots

Central venous lines and certain chemotherapy drugs can sometimes cause blood clots to form more quickly.

Thiopurine methyltransferase (TPMT) and medicines

When you take a medicine (drug), your body has to have a way to handle the medicine. One way is for enzymes to metabolize (break down) the medicine. An enzyme called thiopurine methyltransferase (TPMT) has the ability to break down a class of medicines called thiopurines.

Treatment risks if pregnant

Sometimes medical treatments can delay the start of menstrual periods. However, a girl can still become pregnant even if she has never had a period or has stopped having periods because of medical treatments.