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Research
Solid Tumor : Non-metastatic Ewing sarcoma
Ewing's sarcoma is a malignant (cancerous) bone tumor that affects children and young adults. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. A localized tumor is one that has not spread to any other places in the body. The current standard treatment for patients with localized Ewing sarcoma is to give chemotherapy (cancer fighting medicine) and then either remove the tumor by surgery or treat the tumor with radiation therapy. Some patients will have both surgery and radiation therapy. The standard chemotherapy combination used to treat Ewing sarcoma is vincristine, doxorubicin and cyclophosphamide (VDC) and ifosfamide and etoposide (IE). In this study, Researchers want to find out if they can improve the treatment for this disease by adding another drug called topotecan to the 5 drugs used in standard treatment. This drug topotecan was chosen because the combination of topotecan and cyclophosphamide has been found to be useful in treating some people with Ewing sarcoma when it has come back after treatment (recurrence). The combination of vincristine/topotecan/cyclophosphamide (VTC) has been well-tolerated in people with other types of sarcoma.
The overall goal of this study is to find if adding the drug combination VTC to the standard five-drug chemotherapy for Ewing sarcoma will get rid of the cancer better than the standard five-drug chemotherapy by itself.
For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).
Fariba Navid, MD
St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105 USA
Voice: 1-888-226-4343 or 901-595-4055
Fax: 901-595-4011
Referring or consulting physicians only: protocolinfo@stjude.org
For all other inquiries about St. Jude Children's Research Hospital studies: info@stjude.org
The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.
