James Boyett, PhD

    James M. Boyett, PhD

    Member, St. Jude Faculty
    Endowed Chair of Biostatistics
    Director, Biostatistics Shared Resource for the St. Jude Cancer Center
    Executive Director, Operations and Biostatistics Center, Pediatric Brain Tumor Consortium

    Departments

    Biostatistics

    Contact Information

    James Boyett, PhD
    Biostatistics
    MS 768
    St. Jude Children's Research Hospital
    262 Danny Thomas Place
    Memphis, TN 38105-3678
    Email: james.boyett@stjude.org
    Phone: (901) 595-4986
    FAX: (901) 595-8843

    Education

    BEE - Georgia Tech (1966)
    MA - University of Alabama, Huntsville (1970)
    MS - Michigan State University (1971)
    PhD - Michigan State University (1974)

    Professional Experience


    Honors & Awards


    Research Interests


    Selected Publications

    Donahue B, Marymont MA, Kessel S, Iandoli MK, Fitzgerald T, Holmes E, Kocak M, Boyett JM, Gajjar A, Packer RJ. Radiation Therapy Quality in CCG/POG Intergroup 9961: Implications for Craniospinal Irradiation and the Posterior Fossa Boost in Future Medulloblastoma Trials. Front Oncol 2:185, 2012. doi: 10.3389/fonc.2012.00185. Epub Dec 11 2012. PMID: 23316474

    Fangusaro J, Gururangan S, Jakacki RI, Kaste SC, Goldman S, Pollack IF, Boyett JM, Kun LE. Bevacizumab-Associated Osteonecrosis of the Wrist and Knee in Three Pediatric Patients With Recurrent CNS Tumors. Journal Clinical Oncology Nov 19, 2012. [Epub ahead of print] PMID: 23169504

    Gururangan S, Fangusaro J, Young Poussaint T, Onar-Thomas A, Gilbertson RJ, Vajapeyam S, Gajjar A, Goldman S, Friedman HS, Packer RJ, Boyett JM, Kun LE. Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma--a Pediatric Brain Tumor Consortium study. Neuro Oncol Nov; 14(11):1404-12, 2012. doi: 10.1093/neuonc/nos213. Epub Sep 26, 2012. PMID: 23019233

    Blaney SM, Kocak M, Gajjar A, Chintagumpala M, Merchant T, Kieran M, Pollack IF, Gururangan S, Geyer R, Phillips P, McLendon RE, Packer R, Goldman S, Banerjee A, Heideman R, Boyett JM, Kun L. Pilot study of systemic and intrathecal mafosfamide followed by conformal radiation for infants with intracranial central nervous system tumors: a pediatric brain tumor consortium study (PBTC-001). Journal of Neurooncology Sep:109(3):565-71, 2012. doi: 10.1007/s11060-012-0929-x. Epub Jul 13, 2012. PMID: 22790443

    Warren KE, Gururangan S, Geyer JR, McLendon RE, Poussaint TY, Wallace D, Balis FM, Berg SL, Packer RJ, Goldman S, Minturn JE, Pollack IF, Boyett JM, Kun LE. A Phase II Study of O6- Benzylguanine and Temozolomide in Pediatric Patients with Recurrent or Progressive High-Grade Gliomas and Brainstem Gliomas: A Pediatric Brain Tumor Consortium Study. Journal of Neurooncology Feb; 106(3):643-9, 2012. Epub 2011 Oct. 4.

    Fouladi M, Stewart CF, Olson J, Wagner LM, Onar-Thomas A, Kocak M, Packer RJ, Goldman S, Gururangan S, Gajjar A, Demuth T, Kun LE, Boyett JM, Gilbertson RJ. Phase I Trial of MK-0752 in Children with Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study. Journal of Clinical Oncolology Sep 10;29(26):3529-34, 2011. PMCID: 3179253

    Ellison DW, Kocak M, Figarella-Branger D, Felice G, Catherine G, Pietsch T, Frappaz D, Massimino M, Grill J, Boyett JM, Grundy RG. Histopathological Grading of Pediatric Ependymoma: Reproducibility and Clinical Relevance in European Trial Cohorts. J Negat Results Biomed May 31;10:7, 2011. PMCID: 3117833

    Mikkelsen TS, Sparreboom A, Cheng C, Zhou Y, Boyett JM, Raimondi SC, Panetta JC, Bowman WP, Sandlund JT, Pui CH, Relling MV, Evans WE. Shortening Infusion Time for High-Dose Methotrexate Alters Antileukemic Effects: A Randomized Prospective Clinical Trial. Journal of Clinical Oncology May 1: 29(13):1771-8, 2011. Epub 2011 Mar 28.

    Poussaint TY, Kocak M, Vajapeyam S, Packer RI, Robertson RL, Geyer R, Haas-Kogan D, Pollack IF, Vezina G, Zimmerman R, Cha S, Patay Z, Boyett JM, Kun LE. MRI as a Central Component of Clinical Trials Analysis in Brainstem Glioma: A Report from the Pediatric Brain Tumor Consortium (PBTC). Neuro Oncol Apr 13(4):417-27, 2011. Epub 2011 Feb. 4. PMCID: PMC3064695

    Pollack IF, Stewart CF, Kocak M, Poussaint TY, Broniscer A, Banerjee A, Douglas JG, Kun LE, Boyett JM, Geyer JR. A Phase II Study of Gefitinib and Irradiation in Children with Newly Diagnosed Brainstem Gliomas: A Report from the Pedatric Brain Tumor Consortium. Neuro Oncol Mar 13(3):290-7, 2011. Epub 2011 Feb 3. PMCID: PMC3064605

    Zhao W, Boyett JM, Kocak M, Ellison D, Wu Y. Maximum Likelihood Estimation of Reviewers’ Acumen in Central Review Setting: Categorical Data. Theor Biol Med Model Mar 25:8(1):3, 2011. Epub ahead of print.

    Haas-Kogan DA, Banerjee A, Poussaint TY, Kocak M, Prados MD, Geyer JR, Fouladi M, Broniscer A, Minturn JE, Pollack IF, Packer RJ, Boyett JM, Kun LE. Phase II Trial of Tipifarnib and Radiation in Children with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas. Neuro Oncol Mar; 13(3):298-306, 2011. PMCID: PMC3064607

    Zukotynski KA, Fahey FH, Kocak M, Alavi A, Wong TZ, Treves ST, Shulkin BL, Haas-Kogan DA, Geyer JR, Vajapeyam S, Boyett JM, Kun LE, Poussaint TY. Evaluation of 18F-FDG PET and MRI Associations in Pediatric Diffuse Intrinsic Brain Stem Glioma: A Report from the Pediatric Brain Tumor Consortium. J Nucl Med Feb 52(2):188-95, 2011. Epub 2011 Jan 13.

    Prabhu SP, Ng S, Vajapeyam S, Kieran MW, Pollack IF, Geyer R, Haas-Kogan D, Boyett JM, Kun L, Poussaint TY. DTI Assessment of the Brainstem White Matter Tracts in Pediatric BSG Before and After Therapy: A Report from the Pediatric Brain Tumor Consortium. Childs Nerv Syst Jan;27(1):11-8, 2011. Epub 2010 Nov 4.

    Warren KE, Goldman S, Pollack IF, Fangusaro J, Schaiquevich P, Stewart CF, Wallace D, Blaney SM, Parker R, Macdonald T, Jakacki R, Boyett JM, Kun LE. Phase I Trial of Lenalidomide in Pediatric Patients with Recurrent, Refractory, or Progessive Primary CNS Tumors: Pediatric Brain Tumor Consortium Study PBTC-018. Journal of Clinical Oncology Jan 20:29(3):324-9, 2011. Epub 2010 Dec 13. PMCID: PMC3056466

    Fouladi M, Stewart CF, Blaney SM, Onar-Thomas A, Schaiquevich P, Packer RJ, Gajjar A, Kun LE, Boyett JM, Gilbertson RJ. Phase I Trial of Lapatinib in Children with Refractory CNS Malignancies: A Pediatric Brain Tumor Consortium Study. Journal of Clinical Oncology Sep 20;28(27):4221-7, 2010. Epub 2010 Aug 16. PMCID: PMC2953974

    Geyer JR, Stewart CF, Kocak M, Broniscer A, Phillips P, Douglas JG, Blaney SM, Packer RJ, Gururangan S, Banerjee A, Kieran MW, Kun LE, Gilbertson RJ, Boyett JM.  A Phase I and Biology Study of Gefitinib and Radiation in Children with Newly Diagnosed Brain Stem Gliomas or SupratentorialMalignant Gliomas. Eur J Cancer Aug 12, 2010. (Epub ahead of print). PMCID: PMC2988095

    Gururangan S, Chi SN, Young Poussaint T, Onar-Thomas A, Gilbertson RJ, Vajapeyam S, Friedman HS, Packer RJ, Rood BN, Boyett JM, Kun LE. Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma: A Pediatric Brain Tumor Consortium Study. Journal of Clinical Oncology Jun 20:28(18):3069-75, 2010. Epub 2010 May 17. PMCID: PMC2903337

    Asfar T, Klesges RC, Sanford SD, Sherrill-Mittleman D, Robison LL, Hudson MM, Somes G, Boyett JM, Lando H. Trial Design: The St. Jude Children’s Research Hospital Cancer Survivors Tobacco Quit Line Study. Contemporary Clinical Trials Jan; 31(1):82-91, 2010. Epub 2009 Sep 18. PMCID: PMC2818168

    Onar A, Ramamurthy U, Wallace D, Boyett JM. An Operational Perspective of Challenging Statistical Dogma while Establishing a Modern, Secure Distributed Data Management and Imaging Transport System – The Pediatric Brain Tumor Consortium Phase I Experience. Clinical and Translational Science 2(2):143-149, 2009 PMCID: PMC2877373

    Yetgin S, Ozbek NY, Masera G, Valsecchi MG, Dacou V, Loening L, Schrappe M, Zimmermann M, Henze G, von Stackelberg A, Gadner H, Mann G, Attarbaschi A, Brandalise SR,Carroll WL, Gaynon P, Boyett JM, Nachman J, Devidas M, Sather HN, Escherich G, Janka G, Gelber RD, Sallan SE, Pieters R, Bierings M, Kamps WA, Otten J, Suciu S, Viana MB, Baruchel A, Auclerc M, Perez C, Solidaro A, Stark B, Steinberg D, Koizumi S, Tsurusawa M, Zintl F, Schiller I, Matsuzaki A, Eden TOB, Lilleyman JS, Richards S, Steinherz PG, Steinherz L, Kochupillai V, Bakhshi S, Ortega JJ, Nachman J, Appelbaum FR, Cheng C, Pei D, Pui CH, Kukure P, Nakazawa S, Tsuchida M, Elphinstone T, Evans V, Gettins L, Hicks C, MacKinnon L, Morris P, Richards S, Wade R. Beneficial and harmful effects of anthracyclines in the treatment of childhood acute lymphoblastic leukaemia: a systematic review and meta-analysis. Br J Haematol 145 (3):376-388, May 2009. PMCID: PMC2812732

    Zhao W, Hevener KE, White SW, Lee RE, Boyett JM. A Statistical Framework to Evaluate Virtual Screening. BMC Bioinformatics Jul 20; 10:225, 2009. PMCID: PMC2722655

    Pui C-H, Campana D, Pei D, Bowman PW, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Coustan-Smith E, Kun LE, Jeha S, Cheng C, Howard SC, Simmons V, Bayles A, Metzger ML, Boyett JM, Leung W, Downing JR, Evans WE, Relling MV. Treatment of Childhood Acute Lymphoblastic Leukemia without Prophylactic Cranial Irradiation. New England Journal of Medicine Jun 25; 360(26):2730-41, 2009. PMCID: PMC2754320

    Xiong X, Boyett JM, Webster RG, Stech J. A Stochastic Model for Estimation of Mutation Rates in Multiple-Replication Proliferation Processes. J Math Biol Aug; 59(2):175-91, 2009. Epub Oct. 10, 2008. PMCID: PMC2692649

    Kieran MW, Supko JG, Wallace D, Fruscio R, Poussaint TY, Phillips P, Pollack I, Packer R, Boyett JM, Blaney S, Banerjee A, Geyer R, Friedman H, Goldman S, Kun LE, MacDonald T; Pediatric Brain Tumor Consortium. Phase I Study of SU5416, a Small Molecule Inhibitor of the Vascular Endothelial Growth Factor Receptor (VEGFR) in Refractory Pediatric Central Nervous System Tumors. Pediatric Blood & Cancer Feb;52(2): 169-76, 2009. PMCID: PMC2775441

    Onar A, Kocak M, Boyett JM. Continual Reassessment Method vs. Traditional Empirically Based Design: Modifications Motivated by Phase I Trials in Pediatric Oncology by the Pediatric Brain Tumor Consortium. Journal of Biopharmaceutical Statistics 19(3):437-55, 2009.

    Last update: March 2013