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Finding Cures. Saving Children.
James M. Boyett, PhD
Member, St. Jude Faculty
Endowed Chair of Biostatistics
Director, Biostatistics Shared Resource for the St. Jude Cancer Center
Executive Director, Operations and Biostatistics Center, Pediatric Brain Tumor Consortium
Departments
Biostatistics
Contact Information
James Boyett, PhD
Biostatistics
MS 768
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: james.boyett@stjude.org
Phone: (901) 595-4986
FAX: (901) 544-8843
Education
BEE - Georgia Tech (1966)
MA - University of Alabama, Huntsville (1970)
MS - Michigan State University (1971)
PhD - Michigan State University (1974)
Research Interests
- Clinical trial designs
- Computing infrastructures to support multi-center clinical rrials
- Pediatric CNS tumors
Selected Publications
Sanders RP, Onar A, Boyett JM, Broniscer A, Morris ED, Qaddoumi I, Armstrong GT, Boop FA, Sanford RA, Kun LE, Merchant TE, Gajjar A. M1 Medulloblastoma: High Risk at Any Age. J Neurooncol Dec; 90(3):351-5, 2008. Epub August 15, 2008. PMID: PMC18704266
Fouladi M, Chintagumpala M, Ashley D, Kellie S, Gururangan S, Hassall T, Gronewold L, Stewart C, Wallace D, Broniscer A, Hale G, Kasow K, Merchant T, Morris B, Krasin M, Kun L, Boyett J and Gajjar, A. Amifostine Protects Against Cisplatin-Induced Ototoxicity in Children with Average-Risk Medulloblastoma. Journal of Clinical Oncology August 1; 26(22):3749-55, 2008. PMID: PMC18669462
Broniscer A, Grurangan S, MacDonald TJ, Goldman S, Parker RJ, Stewart CF, Wallace D, Danks MK, Friedman HS, Poussaint TY, Kun LE, Boyett JM, Gajjar A. Phase I Trial of Single-Dose Temozolomide and Continuous Administration of 06-Benzylguanine in Children with Brain Tumors: A Pediatric Brain Tumor Consortium Report. Clinical Cancer Research Nov. 15; 13(22 Pt 1): 6712-8, 2007.
Pollack IF, Jackacki RI, Blaney SM, Hancock ML, Kieran MW, Phillips P, Kun LE, Friedman H, Packer R, Banerjee A, Geyer JR, Goldman S, Poussaint TY, Krasin MJ, Wang Y, Hayes M, Murgo A, Weiner S, Boyett JM. Phase I Trial of Imatinib in Children with Newly Diagnosed Brainstem and Recurrent Malignant Gliomas: A Pediatric Brain Tumor Consortium Report. Neuro-Oncology Apr: 9(2), 145-160, 2007.
Hu XJ, Schroeder RJ, Wang WC, Boyett JM. Pseudoscore Based Estimation from Biased Observations. Statistics in Medicine June; 26(14): 2836-52, 2007.
Xiong X, Tan M, Boyett JM. A Sequential Procedure for Monitoring Clinical Trials Against Historical Controls. Statistics in Medicine 26:1497-511, 2007.
Srivastava DK, Boyett JM, Jackson CW, Tong X, Rai SN. A Comparison of Permutation Hotelling’s T2 Test and Log-Ratio Test for Analyzing Compositional Data. Communications in Statistics – Theory and Methods Volume 36 (2), 451-431, 2007.
Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahern V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale G, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D, Gilbertson RJ. Risk Adapted Craniospinal Radiotherapy Followed by High-Dose Chemotherapy and Stem-Cell Rescue in Children with Newly Diagnosed Medulloblastoma (St Jude Medulloblastoma-96): Long-Term Results From a Prospective, Multicentre Trial. The Lancet Oncology Oct; 7(10): 813-20, 2006.
Broniscer A, Laningham FH, Kocak M, Krasin MJ, Fouladi M, Merchant TE, Kun LE, Boyett JM, Gajjar A. Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma. Cancer 106(6): 1364-1371, 2006.
Gururangan S, Petros WP, Poussaint TY, Hancock ML, Phillips PC, Friedman HS, Bomgaars L, Blaney SM, Kun LE, Boyett JM. Phase I Trial of Intrathecal Spartaject Busulfan in Children with Neoplastic Meningitis: a Pediatric Brain Tumor Consortium Study (PBTC-004). Clin Cancer Res 12(5): 1540-1546, 2006.
Blaney SM, Boyett J, Friedman H, Gajjar A, Geyer R, Horowitz M, Hunt D, Kieran M, Kun L, Packer R, Phillips P, Pollack IF, Prados M, Heideman R. Phase I Clinical Trial of Mafosfamide in Infants and Children Aged 3 Years or Younger with Newly Diagnosed Embryonal Tumors: A Pediatric Brain Tumor Consortium Study (PBTC-001). Journal of Clinical Oncology Jan 20;23(3):525-31, 2005.
Cheng C, Pounds SB, Boyett JM, Pei D, Kuo M-L, Roussel MF. Statistical Significance Threshold Criteria for Analysis of Microarray Gene Expression Data. Statistical Applications in Genetics and Molecular Biology 3(1):36, 2004.
Pollack IF, Boyett JM, Yates AJ, Burger PC, Gilles FH, Davis RL, Finlay JL; Children’s Cancer Group. The Influence of Central Review on Outcome Associations in Childhood Malignant Gliomas: Results from the CCG-945 Experience. Neuro-Oncology 5(3):197-207, 2003.
Sawyer MB, Innocenti F, Das S, Cheng C, Ramirez J, Pantle-Fisher FH, Wright C, Pei D, Boyett JM, Cook EH, Ratain MJ. A Pharmacogenetic Study of Uridine Diphosphate-Glucuronosyltransferase 2B7 in Patients Receiving Morphine. Clinical Pharmacology and Therapeutics 73(6):566-74, 2003.
Xiong X, Tan M, Boyett JM. Sequential Conditional Probability Ratio Tests for Nomalized Test Statistic on Information Time. Biometrics 59:624-631, 2003.
Relling M, Boyett JM, Pui C-H, Evans W, Kun L, Blanco J, Raimondi S, Behm F, Sandlund J, Rivera G. Granulocyte-Colony Stimulating Factor and the Risk of Secondary Myeloid Malignancy after Etoposide Treatment. Blood 101(10) 3862-7, 2003.
Pui C-H, Gaynon PS, Boyett JM, Chessells JM, Baruchel A, Kamps W, Silverman LB, Biondi A, Harms DO, Vilmer E, Schrappe M, Camitta B. Outcome of Treatment in Childhood Acute Lymphoblastic Leukaemia with Rearrangements of the 11q23 Chromosomal Region. Lancet 359:1909-15, 2002.
Pollack IF, Finkelstein SD, Woods J, Burnham J, Holmes EJ, Hamilton RL, Yates AJ, Boyett JM. Expression of p53 and Prognosis in Children with Malignant Gliomas. The New England Journal of Medicine 346: 420-427, 2002.
Packer RJ, Boyett JM, Janss AJ, Stavrou T, Kun L, Wisoff J, Russo C, Geyer R, Phillips P, Kieran M, Greenberg M, Goldman S, Hyder D, Heideman R, Jones-Wallace D, Gilbert AP, Smith SH, and Moshang T. Growth Hormone Replacement Therapy in Children with Medulloblastoma: Use and Effect on Tumor Control. Journal of Clinical Oncology 19(2): 480-487, 2001.
Liu A, Boyett JM, Xiong X. Sample Size Calculation for Planning Group Sequential Longitudinal Trials. Stat Med 19 (2): 205-220, 2000.
Relling MV, Rubnitz JE, Rivera GK, Boyett JM, Hancock M, Felix CA, Kun LE, Walter AW, Evans WE, Pui C-H. High Incidence of Secondary Brain Tumours after Radiation therapy and Antimetabolites Therapy. Lancet 354 (9172): 34-39, 1999.
Last update: May 2009
