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Finding Cures. Saving Children.
2004 News Release Archive
Scientists at St. Jude Children's Research Hospital have discovered that the shape of a protein on the surface of pneumonia bacteria helps these germs invade the human bloodstream.
New guidelines established by national experts hold the promise of reducing illness and death among adult survivors of childhood cancers.
The development of a laboratory model for a rare, inherited form of blindness holds promise that scientists might one day be able to test new treatments to prevent or cure this devastating disease of the retina.
Former St. Jude Director Arthur W. Nienhuis, M.D., and George Simon, chair of the St. Jude Board of Governors, recently announced that William E. Evans, Pharm.D., assumed the position of St. Jude Director and CEO. Nov. 1, 2004.
James Downing, MD, has been named St. Jude Scientific Director. Downing, who will continue serving as Pathology chair, is looking forward to working more closely with researchers and hospital leaders throughout the institution.
Children who suffer from behavioral and learning problems after their central nervous systems have been exposed to chemotherapy or radiation appear to benefit from treatment with methylphenidate (MPH), the drug commonly known by the brand name Ritalin®.
Irradiation and high-dose chemotherapy used to treat two types of brain tumor, medulloblastoma and supratentorial PNE, can cause changes in the brain's white matter that look like tumors when seen on MRI scans.
Brian P. Sorrentino, M.D., of St. Jude Children's Research Hospital, has won a prestigious award from the International Society of Experimental Hematology.
The National Cancer Institute has announced the establishment of the Pediatric Preclinical Testing Program (PPTP), a program that will systematically test 10-15 agents or combinations of agents annually in preclinical models of common childhood cancers.
St. Jude has been named by Scientific American magazine as a research leader within the 2004 Scientific American 50, the magazine's prestigious annual list recognizing outstanding acts of leadership in science and technology.
Charles J. Sherr, M.D., Ph.D., of St. Jude Children's Research Hospital, has been elected to the Institute of Medicine (IOM), a prestigious branch of the National Academy of Sciences.
Part of a cellular mechanism that regulates the folding of new proteins into their proper shapes also includes a genetic response that enlarges the factory where both protein folding and packaging of proteins occurs.
Improved risk classification for patients with acute lymphoblastic leukemia (ALL), coupled with more intensive intrathecal chemotherapy for high risk patients and the use of a drug called dexamethasone, could one day permit physicians to omit irradiation.
The discovery that the Lag-3 gene acts as a brake to prevent immune system responses from running out of control solves a mystery that has puzzled researchers since the gene was discovered 14 years ago.
Exercise might one day provide a non-invasive, non-pharmaceutical way to protect adults against the onset of symptoms of Parkinson's disease (PD).
The condition of mice with a genetic blood disease called beta-thalassemia improved significantly following treatment of their blood forming cells with a gene that enabled them to produce the type of hemoglobin normally found only in the fetus.
Protein protecting brain from toxins also blocks some chemotherapy from reaching tumors.
The eradication of brain tumors in mice following treatment with a novel drug suggests that certain cancers might one day be cured without the use of toxic chemotherapy and radiation.
Results of a laboratory study suggest that St. Jude researchers have identified primitive blood cells that are responsible for bone repair and regeneration. A single type of stem cell gave rise in a laboratory model to both blood-forming and bone-forming cells. This newly discovered cell might one day be the basis of new medical treatment to replace bone that has been lost to disease or injury.
Images of anthrax enzyme help researchers understand antibiotic resistance, suggest design for better drugs.
Enzyme that maintains chromosome "ends" is linked to bone cancer recurrence, decreased survival.
Excess accumulation in brain cells of a fat molecule called GM1-ganglioside (GM1) disrupts the folding of newly assembled proteins into their proper shapes, triggering nerve degeneration and mental retardation in children.
A unique tail at one end of a protein called Ubc12 stabilizes a molecular workshop that assembles the "on-switch" cells used to accelerate cell replication.
The Chili's Care Center at St. Jude Children's Research Hospital will house the Department of Radiological Sciences and will provide space for future expansion of inpatient activities and new research laboratories.
Scientists at St. Jude Children's Research Hospital are investigating in adults the use of a vaccine given by nose drops that might ultimately protect children against human parainfluenza virus-type 1 (hPIV-1).
The lack of a gene called LBP-1a in the mouse embryo prevents normal growth of blood vessels in the placenta. This finding suggests that a similar defect in humans could play a role in fetal growth retardation, infant mortality and spontaneous abortion.
A radiation therapy technique that kills brain tumors in children while sparing normal tissue allows young patients to enjoy normal development of memory, reasoning, problem-solving and other cognitive functions.
A relatively small number of genes are linked to either resistance or sensitivity to four major cancer drugs used to treat acute lymphoblastic leukemia (ALL), suggesting that these genes are key to treatment outcome.
Microarray data will help classify major subtypes of acute myeloid leukemia and speed understanding of the altered biology that causes this cancer in adults and children
An avian influenza virus that has caused three major outbreaks among poultry and killed several people in East Asia over the past seven years arose through a series of genetic reassortment events with other viruses.
St. Jude Children's Research Hospital is currently featured in U.S. News & World Report's special 'Best Hospitals in America' edition (July 12, 2004 edition.)
The development of a mouse model that closely mimics the human eye cancer retinoblastoma, gives investigators a way to test new therapies for this disease in the laboratory for the first time.
Data from a clinical trial led by investigators at St. Jude Children's Research Hospital with the investigational agent clofarabine were presented June 5 at the 40th annual meeting of the American Society of Clinical Oncology.
Nature article from St. Jude points to challenges ahead and approaches that will be required to individualize drug therapy based on a patient's genetic make-up.
Accelerate Brain Cancer Cure (ABC2) and the Pediatric Brain Tumor Foundation (PBTF) have jointly awarded a research grant to Tom Curran, Ph.D., co-leader of the Neurobiology & Brain Tumor Program at St. Jude to support his work.
The city of Recife, Brazil, experienced a significant improvement in outcome among children treated for acute lymphoblastic leukemia (ALL) during the past decade, even though the community is resource-poor and most patient families are impoverished.
Inactivating a protective molecule in leukemic cells to make them more vulnerable to chemotherapy might also make healthy blood-forming cells more sensitive to the toxic effects of those same drugs.
Marlo Thomas appeared before Congress on Tuesday, April 27, to discuss the need for more brain tumor research funds.
New insight into the structure of a virus enzyme that orchestrates a natural type of genetic engineering in bacteria provides important clues into how similar enzymes control the same process in human cells during DNA replication and repair.
The cure rate for pediatric acute lymphoblastic leukemia (ALL) may continue to rise with improved use of conventional therapies. But even better therapies based on genetic and pharmacogenetic studies might one day push success rate to 100 percent.
A genetic trick used by viruses to replicate themselves has been adapted for laboratory use to build complex protein structures required by immune system cells, according to investigators at St. Jude Children's Research Hospital.
Michael Dyer's St. Jude team showed that Rb limits the proliferation of immature retinal cells so the retina develops to a normal size. The Rb protein also prompts specific cells to develop into light-sensitive cells called rods.
Discovery of the sequence of events in the binding of p27 to a protein complex is a model for explaining how 30 to 40 percent of the body's proteins exploit their flexibility in order to do different tasks in the cell
The finding that a tumor-suppressor protein called Rb is required for proper development of the mouse retina is a major step toward understanding why some children develop the devastating eye cancer called retinoblastoma.
Clinical researchers are getting closer to an international clinical trial to improve guidelines for treatment of medulloblastoma.
Inactivation of the gene CBP in certain immature white blood cells of mice causes lymphoma, a type of cancer also found in humans. The cancer is accompanied by changes in the expression of specific genes associated with development of the disease.
Research conducted by St. Jude scientists may help uncover the genetic causes of certain muscle diseases that occur for unknown reasons in children. This research found that a novel protein Ozz directs the destruction of a structural protein in muscle that helps organize and stabilize muscle growth.
St. Jude has been using online auctions for about four years and engages in two or three large online auctions each year.
St. Jude Children's Research Hospital has joined the ranks of supercomputer users around the world with installation of an IBM computer system that can perform more than 600 billion operations per second.
Milestone discovery of the 3-D structure and function of vinculin explains how this protein changes its shape to perform different functions in health and disease.
