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Finding Cures. Saving Children.
Diagnostic Imaging
The Division of Diagnostic Imaging continues to build upon its solid base of providing clinical diagnostic information and is moving toward the generation of more quantitative data that can be used for real-time modification and enhancement of therapies tested in front-line leukemia protocols at St. Jude. One goal is to use quantitative information derived from MR imaging to assess the severity of leukoencephalopathy, so that the optimum ratio of risk to benefit can be achieved when the risk of leukoencephalopathy must be balanced with the need for specific chemotherapy.
A new direction for the Division of Diagnostic Imaging is the quantitative assessment of bone mineralization. Low bone mineral density is increasingly recognized as an important complication in patients undergoing therapy for cancer. With early recognition and appropriate intervention, this side effect may be lessened for a broad range of patients who are treated with various types of anticancer therapy.
Quantitative methods of T1 measurement developed within the department are now being used to detect subtle variations from normalcy in brain tissues; these variations cannot be identified by conventional MR imaging. This new capability may allow the detection of disease states that could not previously be identified by imaging studies and may shed new light on the effect of radiation therapy on normal brain tissues.
Another new imaging method being developed in conjunction with conventional MR imaging is functional MR imaging, which shows activation of brain metabolism during repetitive tasks. This technique is being used to characterize patients who, after therapy, have symptoms similar to those of attention deficit disorder. It is hoped that this method will lead to interventions that can improve the quality of these patients’ lives.
