Currently we test and support the following browsers:
Please note that this is not intended to be an exhaustive list of browsers that support web standards, nor a test of browser compliance, nor a side-by-side comparison of various manufacturers’ browsers.
Member, St. Jude Faculty
Vice Chair, Immunology
Immunology
Dario A Vignali, PhD
Immunology
MS 351, Room E7054
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email: dario.vignali@stjude.org
Phone: (901) 595-2332
FAX: (901) 595-3107
PhD - London School of Hygiene & Tropical Medicine, University of London
Various aspects of T cell function:
To request reprints and reagents: vignali.lab@stjude.org
Bettini M, Szymczak-Workman AL, Forbes K, Castellaw AH, Selby M, Pan X, Drake CG, Korman AJ, Vignali DA. Cutting edge: accelerated autoimmune diabetes in the absence of LAG-3. J Immunol August 26, 2011.
Delgoffe GM, Murray PJ, Vignali DA. Interpreting mixed signals: the cell's cytokine conundrum. Curr Opin Immunol Aug 16, 2011.
Chaturvedi V, Collison LW, Guy CS, Workman CJ, Vignali D. Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance. J Immunol 186:6661-6666, 2011.
Workman CJ, Collison LW, Bettini M, Pillai MR, Rehg JE, Vignali DA. In vivo Treg suppression assays. Methods Mol Biol 707:119-156, 2011.
Collison LW, Vignali DA. In vitro Treg suppression assays. Methods Mol Biol 707:21-37, 2011.<>/p>
Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti J, Finkelstein D, Forbes K, Workman CJ, Brown SA, Rehg JE, Jones ML, Ni HT, Artis D, Turk MJ, Vignali DA. IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol 11:1093-1101, 2010.
Woo SR, Li N, Bruno TC, Forbes K, Brown S, Workman C, Drake CG, Vignali DAA. Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4. Eur J Immunol 40:1768-1777, 2010.
Burton AR, Baquet Z, Eisenbarth GS, Tisch R, Smeyne R, Workman CJ, Vignali DAA. Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4( ) T cells. J Immunol 184:4863-4870, 2010.
Wang H, Holst J, Woo SR, Guy C, Bettini M, Wang Y, Shafer A, Naramura M, Mingueneau M, Dragone LL, Hayes SM, Malissen B, Band H, Vignali DAA. Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development. Embo J 29:1285-1298, 2010.
Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DAA, Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol 11:70-1819, 2010.
Bettini M, Vignali DAA. Regulatory T cells and inhibitory cytokines in autoimmunity. Curr Opin Immunol 21:612-618, 2009.
Lennon GP, Bettini M, Burton AR, Vincent E, Arnold PY, Santamaria P, Vignali DAA. T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity 31:643-653, 2009.
Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DAA. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 450:566-569, 2009.
Workman CJ, Szymczak-Workman AL, Collison LW, Pillai MR, Vignali DA. The development and function of regulatory T cells. Cell Mol Life Sci 66:2603-2622, 2009.
Collison LW, Pillai MR, Chaturvedi V, Vignali DAA. Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner. J Immunol 182:6121-6128, 2009.
Szymczak-Workman AL, Vignali, DAA. Cutting Edge: Regulatory T cells do not require stimulation through their T cell receptor to suppress. J Immunol 182:5188-5192, 2009.
Workman CJ, Wang Y, El Kasma KC, Pardoll DM, Murray PJ, Drake CG, Vignali, DAA. LAG-3 negatively regulates plasmacytoid dendritic cell homeostasis. J Immunol 182:1885-91, 2009.
Blackburn SD, Shin H, Haining WN, Workman CJ, Polley A, Betts MR, Freeman GJ, Vignali DAA, Wherry EJ.Co-regulation of CD8 T cell exhaustion during chronic viral infection by multiple inhibitory receptors. Nature Immunology 10:29-37, 2009.
Wang H, Matsuzawa A, Brown S, Zhou J-R, Guy CS, Tseng P-H, Forbes K, Nicholson TP, Sheppard PW, Haecker H, Karin M, Vignali DAA. Analysis of non-degradative protein ubiquitylation with a monoclonal antibody specific for lysine 63-linked polyubiquitin. PNAS 105:20197-20202, 2008.
Vallabhapurapu S, Matsuzawa A, Zhang WZ, Tseng P-H, Keats JJ, Wang H, Vignali DAA, Bergsagel PL, Karin M. TRAF2 and TRAF3 carry out non-redundant and complementary functions to activate NIK-dependent alternative NF-κB signaling. Nature Immunology 9:1364-1370, 2008.
Collison LW, Vignali DAA. Interleukin-35: odd one out or part of the family? Immunological Reviews 226:248–262, 2008.
Matsuzawa A, Tseng P-H, Vallabhapurapu S, Luo J-L, Zhang W, Wang H, Vignali DAA, Gallagher E, Karin K. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 321:663-8, 2008.
Vignali DAA, Collison LW, Workman CJ. How regulatory T cells work. Nature Reviews Immunology 8:523-532, 2008.
Holst J, Wang H, Durick Eder K, Workman CJ, Boyd K, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NSC, Utz PJ, Vignali DAA. T cell receptor:CD3 ITAM-mediated scalable signaling ensures effective negative selection and prevents autoimmunity. Nature Immunology 9:658-666, 2008.
Burton AR, Vincent E, Arnold PY, Lennon, G, Smeltzer M, Li C-S, Haskins K, Hutton J, Tisch RM, Sercarz EE, Santamaria P, Workman CJ, Vignali DAA. On the pathogenicity of autoantigen-specific T cell receptors. Diabetes 57: 1321-1330, 2008.
Vignali DAA. How many mechanisms do regulatory T cells need? Eur J Immunol 38: 901-937, 2008. [Invited Review for EJI in Honor of Rolf Zinkernagel]
Collison LW, Workman CJ, Kuo TK, Boyd K, Wang Y, Vignali K, Cross R, Sehy D, Blumberg RS, Vignali DAA. The inhibitory cytokine IL-35 contributes to regulatory T cell function. Nature 450: 566-569, 2007.
Li N, Wang Y, Forbes K, Vignali KM, Heale BS, Saftig P, Hartmann D, Black R, Rossi JJ, Blobal C, Dempsey PJ, Workman CJ, Vignali DAA. Metalloproteases regulate T cell proliferation and effector function via LAG-3. EMBOJ 26: 494-504, 2007.
Li N, Boyd K, Dempsey PJ, Vignali DAA. Non-cell autonomous expression of TNF-α-converting enzyme ADAM17 is required for normal lymphocyte development. J Immunol 178: 4214-4221, 2007.
Holst J, Szymczak-Workman AL, Vignali KM, Burton AR, Workman CJ, Vignali DAA. Generation of T cell receptor retrogenic mice. Nature Protocols 1:406-417, 2006.
Holst J, Vignali KM, Burton AR, Vignali DAA. Rapid analysis of T cell selection and function in vivo using T cell receptor retrogenic mice. Nat Methods 3:191-197, 2006.
Szymczak A, Workman CJ, Gill D, Dilioglou S, Vignali KM, Palmer E, Vignali DAA. The CD3ε proline-rich sequence, and its interaction Nck, is not required for T cell development and function. J Immunol 175:270-275, 2005.
Szymczak A, Vignali DAA. Plasticity and rigidity in AP-2-mediated internalization of the T cell receptor: CD3 complex. J Immunol 174:4153-4160, 2005.
Workman CJ, Vignali DAA. Negative regulation of T cell homeostasis by LAG-3 (CD223). J Immunol 174:688-695, 2005.
Li N, Workman CJ, Martin SM, Vignali DAA. Biochemical analysis of the regulatory T cell protein Lymphocyte Activation Gene-3 (LAG-3; CD223). J Immunol 173:6806-6812, 2004.
Huang C-T, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Lavitsky HI, Powell JD, Pardoll DM, Drake CG, Vignali DAA. Role of LAG-3 in regulatory T cells. Immunity 21:503-13, 2004. [Issue Cover]
Arnold PY, Royer A, Vignali DAA. Diabetes incidence is unaltered in GAD-65-specific TCR retrogenic NOD mice: generation by retroviral-mediated stem cell gene transfer. J Immunol 173:3103-3111, 2004.
Szymczak A, Workman CJ, Wang Y, Vignali KM, Dilioglou S, Vanin E, Vignali DAA. Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nature Biotechnology 22:589-594, 2004.
Workman CJ, Cauley LS, Kim I-J, Blackman M, Woodland DL, Vignali DAA. LAG-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol 172:5450-5455, 2004.
La Gruta NL, Liu HY, Rhodes M, Wiest D, Vignali DAA. Architectural changes in the T cell receptor: CD3 complex induced by MHC: peptide ligation. J Immunol 172:3662-3669, 2004.
Clatza A, Bonifaz LC, Vignali DAA, Moreno J. CD40-induced aggregation of MHC class II and CD80 on the cell surface leads to an early enhancement in antigen presentation. J Immunol 171:6655-6658, 2003.
Workman CJ, Vignali DAA. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Eur J Immunol 33:970-979, 2003.
Cauley LS, Cookenham T, Miller T, Adams PS, Vignali KM, Vignali DAA, Woodland DL. Cutting Edge: Virus-specific CD4 memory T cells in nonlymphoid tissues express a highly activated phenotype. J Immunol 169:6655-6658, 2002.
Arnold PY, Vignali KM, Miller T, La Gruta NL, Cauley LS, Haynes L, Adams PS, Swain S, Woodland DL, Vignali DAA. Reliable generation and use of MHC class II:γ2aFc multimers for the identification of antigen-specific CD4 T cells. J Immunol Methods 271:137-151, 2002.
Workman CJ, Dugger KJ, Vignali DAA. Cutting Edge: Molecular analysis of the negative regulatory function of LAG-3. J Immunol 169:5392-5395, 2002.
Workman CJ, Rice D, Dugger KJ, Kurschner C, Vignali DAA. Phenotypic and kinetic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur J Immunol 32:2255-2263, 2002.
Arnold PY, La Gruta NL, Miller TB, Vignali KM, Adams PS, Woodland DL, Vignali DAA. The majority of immunogenic epitopes generate CD4 T cells that are dependent on MHC class II-bound peptide flanking residues. J Immunol 169:739-749, 2002.
Liu HY, Rhodes M, Wiest D, Vignali DAA. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 13:665-675, 2000. [Issue Cover]
Last update: September 2011
