Rachel C. Brennan, MD
Rachel C. Brennan, MD

Rachel C. Brennan, MD

Associate Member, St. Jude Faculty




BA – Carroll College, Helena, Montana
MD – Johns Hopkins University School of Medicine, Baltimore, Maryland
Internship/Residency (Pediatrics) – Johns Hopkins Hospital, Baltimore, Maryland
Fellowship (Pediatric Hematology/Oncology) – St. Jude Children’s Research Hospital

Research Interests

  • Retinoblastoma: therapy and late effects
  • Translating preclinical research into clinical trials (Lab Liaison)
  • Phase I clinical trials
  • Renal tumors
  • Minimizing early and late complications of chemotherapy

Selected Publications

Brennan RC, Furman W, Mao S, Wu J, Turner DC, Stewart CF, Santana V, McGregor LM. Phase I dose escalation and pharmacokinetic study of oral gefitinib and irinotecan in children with refractory solid tumors. Cancer Chemother Pharmacol 74(6):1191-8, 2014. PMID: 25257509.

Brinkman TM, Merchant TE, Li Z, Brennan R, Wilson M, Hoehn ME, Qaddoumi I, Phipps S, Srivastava D, Robison LL, Hudson MM, Krull KR. Cognitive function and social attainment in adult survivors of retinoblastoma: A report from the St. Jude Lifetime Cohort Study. Cancer Nov 24, 2014. Epub ahead of print. PMID: 25421884.

Tse BC, Kaste SC, Brennan R, Orr B, Wilson MW. Enophthalmos and choroidal atrophy after intraophthalmic artery chemotherapy for retinoblastoma. Ophthalmology Oct 22, 2014. Epub ahead of print. PMID 25439599.

Willard VW, Qaddoumi I, Chen S, Zhang H, Brennan R, Rodriguez-Galindo C, Wilson MW, Phipps S. Developmental and adaptive functioning in children with retinoblastoma: A longitudinal investigation. J Clin Oncol 32(25):2788-93, 2014.

Sullivan EM, Wilson MW, Billups CA, Wu J, Merchant TE, Brennan RC, Haik BG, Rodriguez-Galindo C, Free TM, Given V, Qaddoumi I. Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation. J Pediatr Hematol Oncol Feb 26, 2014. Epub ahead of print. PMID: 24577551.

McEvoy J, Nagahawatte P, Finkelstein D, Richards-Yutz J, Valentine M, Ma J, Mullighan C, Song G, Chen X, Wilson MW, Brennan RC, Pounds S, Becksfort J, Huether R, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Easton J, Zhang J, Downing JR, Ganguly A, Dyer MA. RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget Jan 11, 2014. Epub ahead of print. PMID: 24509483.

Loh AHP, Brennan RC, Lang W, Hickey RJ, Malkas LH, Sandoval JA. Dissecting the PI3K signaling axis in pediatric solid tumors: novel targets for clinical integration. Front Oncol 3:93, 2013. PMCID: PMC3636761.

Bhagat S, Bass J, Qaddoumi I, Brennan R, Wilson M, Wu J, Galindo CR, Paglialonga A, Tognola G. Time-frequency analysis of transient-evoked otoacoustic emissions in children exposed to carboplatin chemotherapy. Audiol Neurootol 18(2):71-82, 2013. PMCID: PMC3777667

McEvoy J, Ulyanov A, Brennan R, Wu G, Pounds S, Zhang J, Dyer MA. Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma.PLoS One 7(8):e42739, 2012. PMCID: PMC3423419.

Huddleston S, McNall-Knapp RY, Siatkowski M, Odom C, Brennan R, Wilson MW. A novel translocation t(11;13) (q21;q14.2) in a child with suprasellar primitive neuroectodermal tumor and retinoblastoma. Ophthalmic Genet 34(1-2):97-100, 2013. PMID: 22924820.

Qaddoumi IQ, Billups C, Tagen M, Stewart C, Wu J, Helton K, McCarville B, Merchant T, Brennan R, Free T, Given V, Haik B, Rodriguez-Galindo C, Wilson MWW. Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity. Cancer 118(22):5663-5670, 2012. PMCID: PMC3413782.

Brennan RC, Wilson MW, Kaste S, Helton K, McCarville B. Ultrasound and MRI of pediatric ocular masses. Pediatr Radiol 42(6):738-749, 2012. PMCID: PMC3530407.

Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA. A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature 481(7381):329-334, 2012. PMCID: PMC3289956.

McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.Cancer Cell 20(2):260-275, 2011. PMCID: PMC3551581.

Brennan R, Federico S, Bradley C, Zhang J, Flores-Otero J, Wilson M, Stewart C, Zhu F, Guy K, Dyer MA. Targeting the p53 pathway in retinoblastoma with subconjunctival nutlin-3a. Cancer Res 71(12):4205-4213, 2011. PMCID: PMC3116943.

Teitz T, Stanke J, Federico S, Bradley C, Brennan R, Zhang J, Johnson MD, Sedlacik J, Inoue M, Zhang Z, Hillenbrand C, Rehg JE, Frase S, Calabrese C, Finkelstein D, Dyer MA, Lahti JM. Preclinical models for neuroblastoma: Establishing a baseline for treatment. PLoS ONE 6(4):e19133, 2011. PMCID: PMC3084749.

Brennan RC, Helton KJ, Pei D, Cheng C, Inaba H, Metzger ML, Howard SC, Rubnitz JE, Ribeiro RC, Sandlund JT, Jeha S, Pui CH, Bhojwani D. Spinal epidural lipomatosis in children with hematologic malignancies. Ann Hematol 90(9):1067-1074, 2011. PMCID: PMC3169011.

Last update: December 2014