MD – São Paulo University Medical School, São Paulo, Brazil (1989)
MS – São Paulo University Medical School, São Paulo, Brazil (2002)
I have focused my clinical research on the care, management, and therapy of children, adolescents, and young adults with aggressive types of gliomas, particularly patients with high-grade glioma. Gliomas constitute the most common group of cancers in the brain and spinal cord in adults and children.
Earlier in my career, I described the results of a multi-institutional clinical trial that used temozolomide in the treatment of children with high-grade and DIPG (SJHG-98). Since March 2005, we have been conducting a new clinical study that combined for the first time an oral, promising chemotherapy called erlotinib and irradiation (SJHG-04) in the treatment of children, adolescents, and young adults with newly diagnosed high-grade and unfavorable low-grade glioma. I have already described the Phase I component of this clinical trial, and we are currently treating a larger number of patients in the Phase II component of this study.
Finally, I have been directly involved in developing new protocols to better understand the biology of these very aggressive tumors in collaboration with several other investigators at our institution. We believe that by better understanding these types of cancer, we may be able to devise better ways to treat affected children. One of these studies is a new clinical trial (NBTP02) where we are conducting a very extensive analysis of the genetic make-up of tumors from children with DIPG.
Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, Qu C, Ding L, Huether R, Parker M, Zhang J, Gajjar A, Dyer MA, Mullighan CG, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Ellison DW, Zhang J, Baker SJ. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet 44(3):251-253, 2012. PMCID: PMC3288377
Paugh BS, Broniscer A, Qu C, Miller CP, Zhang J, Tatevossian RG, Olson JM, Geyer JR, Chi SN, da Silva NS, Onar-Thomas A, Baker JN, Gajjar A, Ellison DW, Baker SJ. Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol 29(30), 3999-4006, 2011. PMCID: PMC3209696
Pollack IF, Stewart CF, Kocak M, Poussaint TY, Broniscer A, Banerjee A, Douglas JG, Kun LE, Boyett JM, Geyer JR. A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol 13(3):290-297, 2011. PMCID: PMC3064605
Haas-Kogan DA, Banerjee A, Poussaint TY, Kocak M, Prados MD, Geyer JR, Fouladi M, Broniscer A, Minturn JE, Pollack IF, Packer RJ, Boyett JM, Kun LE. Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas. Neuro Oncol 13(3):298-306, 2011. PMCID: PMC3064607
Chow LM, Endersby R, Zhu X, Rankin S, Qu C, Zhang J, Broniscer A, Ellison DW, Baker SJ. Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell 19(3):305-316, 2011. PMCID: PMC3060664
Pai Panandiker AS, Merchant TE, Beltran C, Wu S, Sharma S, Boop FA, Jenkins JJ, Helton KJ, Wright KD, Broniscer A, Kun LE, Gajjar A. Sequencing of local therapy affects the pattern of treatment failure and survival in children with atypical teratoid rhabdoid tumors of the central nervous system. Int J Radiat Oncol Biol Phys 82(5):1756-1763, 2011.
Lobel U, Sedlacik J, Reddick WE, Kocak M, Ji Q, Broniscer A, Hillenbrand CM, Patay Z. Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma. AJNR Am J Neuroradiol 32(2):315-322, 2010.
Broniscer A, Baker JN, Tagen M, Onar-Thomas A, Gilbertson RJ, Davidoff AM, Panandiker AP, Leung W, Chin TK, Stewart CF, Kocak M, Rowland C, Merchant TE, Kaste SC, Gajjar A. Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma. J Clin Oncol 28(31):4762-4768, 2010. PMCID: PMC3020706
Lobel U, Sedlacik J, Sabin ND, Kocak M, Broniscer AM, Hillenbrand CM, Patay Z. Three-dimensional susceptibility-weighted imaging and two-dimensional T2*-weighted gradient-echo imaging of intratumoral hemorrhages in pediatric diffuse intrinsic pontine glioma. Neuroradiology 52(12):1167-1177, 2010.
Geyer JR, Stewart CF, Kocak M, Broniscer A, Phillips P, Douglas JG, Blaney SM, Packer RJ, Gururangan S, Banerjee A, Kieran MW, Kun LE, Gilbertson RJ, Boyett JM. A phase I and biology study of gefitinib and radiation in children with newly diagnosed brain stem gliomas or supratentorial malignant gliomas. Eur J Cancer 46(18):3287-3293, 2010. NIHMSID: NIHMS224318
Sedlacik J, Löbel U, Kocak M, Loeffler RB, Reichenbach JR, Broniscer A, Patay Z, Hillenbrand C. Attenuation of cerebral venous contrast in susceptibility-weighted imaging of spontaneously breathing pediatric patients sedated with propofol. AJNR Am J Neuroradiol 31(5):901-906, 2010.
Paugh BS, Qu C, Jones C, Liu Z, Adamowicz-Brice M, Zhang J, Coyle B, Barrow J, Bax DA, Hargrave D, Lowe J, Gajjar A, Zhao W, Broniscer A, Ellison DW, Grundy R, Baker SJ. Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. J Clin Oncol 28(18):3061-3068, 2010. PMCID: PMC2903336
Broniscer A, Baker JN, Baker SJ, Chi SN, Geyer JR, Morris EB, Gajjar A. Prospective collection of tissue samples at autopsy in children with diffuse intrinsic pontine glioma. Cancer 116(19):4632-4637, 2010. PMCID: PMC2989604
Forshew T, Tatevossian RG, Lawson AR, Ma J, Neale G, Ogunkolade BW, Jones TA, Aarum J, Dalton J, Bailey S, Chaplin T, Carter RL, Gajjar A, Broniscer A, Young BD, Ellison DW, Sheer D. (2009). Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas. Journal Pathol 218(2):172-181, 2009.
Van Poppel K, Broniscer A, Patay Z, Morris EB. Alexander disease. An important mimicker of focal brainstem glioma. Pediatr Blood Cancer 53(7):1355-1366, 2009. PMCID: PMC2774853
Morris B, Kasow K, Reis U, Ellison D, Broniscer A. Bone marrow transplantation for severe aplastic anemia secondary to temozolomide. J Neurooncol 91(2):237-239, 2009. PMCID: PMC2736860
Broniscer A, Baker SJ, Stewart CS, Merchant TE, Laningham FH, Schaiquevich P, Kocak M, Morris EB, Endersby R, Ellison DW, Gajjar A. Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma.Clin Cancer Res 15(2):701-707, 2009. PMCID: PMC2629527
Broniscer A, Laningham FH, Sanders RP, Kun LE, Ellison DW, Gajjar A. Young age may predict a better outcome for children with diffuse pontine glioma. Cancer 113(3):566-572, 2008.
Broniscer A, Gururangan S, MacDonald TJ, Goldman S, Packer RJ, Stewart CS, Wallace D, Danks MK, Friedman HS, Poussaint TY, Kun LE, Boyett JM, Gajjar A. Phase I trial of single-dose temozolomide and continuous administration of O6-benzylguanine in children with brain tumors: a Pediatric Brain Tumor Consortium Report. Clin Cancer Res 13(22 Pt 1), 6712-6718, 2007.
Sanders RP, Kocak M, Burger PC, Merchant TE, Gajjar A, Broniscer A. High-grade astrocytoma in very young children. Pediatr Blood Cancer 49(7):888-893, 2007.
Broniscer A, Baker S, West AN, Fraser MM, Proko E, Kocak M, Dalton J, Zambetti GP, Ellison DW, Kun LE, Gajjar A, Gilbertson RJ, Fuller CF. Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. J Clin Oncol 25(6):682-689, 2007.
Broniscer A, Panetta JC, O’Shaughnessy M, Fraga C, Feng B, Krasin MJ, Gajjar A, Stewart CF. Plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite OSI-420. Clin Cancer Res 13(5):1511-1515, 2007.
Broniscer A, Laningham FH, Kocak M, Krasin MK, Fouladi M, Merchant TE, Kun LE, Boyett JM, Gajjar A. Intratumoral hemorrhage among children with newly diagnosed diffuse brainstem glioma.Cancer 106(6):1364-1371, 2006.
Broniscer A, Chintagumpala M, Fouladi M, Krasin MJ, Kocak M, Bowers DC, Iacono LC, Merchant TE, Stewart CF, Houghton PJ, Kun LE, Ledet L, Gajjar A. Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children. Journal of Neuro-Oncology 76(3):313-319, 2006.
Broniscer A, Iacono L, Chintagumpala M, Fouladi M, Wallace D, Bowers DC, Stewart C, Krasin MJ, Gajjar A. Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: Results of a multi-institutional study (SJHG-98). Cancer 103(1):133-139, 2005.
Last update: February 2013