John K. Choi, MD, PhD
John K. Choi, MD, PhD

John K. Choi, MD, PhD

Associate Member, St. Jude Faculty



BS – Cornell University
PhD – University of Pennsylvania
MD – University of Pennsylvania School of Medicine

Research Interests

  • Mechanisms by which the transcription factor E2A regulate normal precursor B cell proliferation.
  • Mechanisms by which mutated E2A promote precursor B lymphoblastic leukemia
  • Clinical laboratory tools for identifying and classifying various hematopathologic disease entities

Selected Publications

Raess PW, Paessler ME, Bagg A, Weiss MJ, Choi JK. α-hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors. Am J Surg Pathol 36(10):1538-47, 2012.

Huppmann AR, Rheingold SR, Bailey LC, Helfrich M, Choi JK. Detection of leukemic lymphoblasts in CSF is instrument-dependent. Am J Clin Pathol 137(5):795-99, 2012.

Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, Paw BN, Weiss MJ. miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev 24(15):1620-33, 2010.

Shaffer MH, Huang Y, Corbo E, Wu GF, Velez M, Choi JK, Saotome I, Cannon JL, McClatchey AI, Sperling AI, Maltzman JS, Oliver PM, Bhandoola A, Laufer TM, Burkhardt JK: Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice. PLoS One 5(8):e12404, 2010.

Miccio A, Wang Y, Hong W, Gregory GD, Wang H, Yu X, Choi JK, Shelat S, Tong W, Poncz M, Blobel GA. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J Jan 2010.

Talaat KR, Rothman JA, Cohen JI, Santi M, Choi JK, Guzman M, Zimmerman R, Nallasamy S, Brucker A, Quezado M, Pittaluga S, Patronas NJ, Klion AD, Nichols KE. Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infection. Pediatr Blood Cancer 53(6):1120-3, 2009.

Sanchez PV, Perry RL, Sarry JE, Perl AE, Murphy K, Swider CR, Bagg A, Choi JK, Biegel JA, Danet-Desnoyers G, Carroll M: A robust xenotransplantation model for acute myeloid leukemia. Leukemia 23(11): 2109-17, 2009.

Corao DA, Biegel JA, Coffin CM, Barr FG, Wainwright LM, Ernst LM, Choi JK, Zhang PJ, Pawel BR. ALK Expression in Rhabdomyosarcomas: Correlation with Histologic Subtype and Fusion Status. Pediatric and Developmental Pathology 12(4): 275-83, 2009.

Roullet M, Shereen MF, Gheith MB, Mauger J, Junkins-Hopkins JM, Choi JK. Percentage of Gamma/Delta T Cells in Panniculitis by Paraffin Immunohistochemistry. AJCP 131:820-826, 2009.

Lian L, Wang Y, Flick M, Choi J, Scott EW, Degen J, Lemmon MA, Abrams CS. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood 113(15):3577-84, 2009.

Teachey DT, Greiner R, Seif A, Attiyeh E, Bleesing J, Choi J, Manno C, Rappaport E, Schwabe D, Sheen C, Sullivan K, Zhuang H, Wechsler D, Grupp SA. Treatment with sirolimus results in complete responses in patients with Autoimmune Lymphoproliferative Syndrome. Brit J Hematol 145(1):101-6, 2009.

Chou ST, Opalinska JB, Yao Y, Fernandez M, Kalota A, Brooks JSJ, Choi JK, Gewirtz A, Danet-Desnoyers G-a, Nemiroff RL, Weiss MJ. Trisomy 21 enhances human fetal erythro-megakaryocytic development. Blood 112(12):4503-6, 2008.

Wang Y, Chen X, Lian L, Tang T, Stalker TJ, Sasaki T, Brass LF, Choi JK, Hartwig JH, Abrams CS. The loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. PNAS 105(37):14064-9, 2008.

Kasprzycka M, Zhang Q, Witkiewicz A, Marzec M, Potoczek M, Liu X, Wang HY, Milone M, Basu S, Mauger J, Choi JK, Abrams T, Hou S, Rook AH, Vonderheid E, Woetmann A, Odum N, Wasik MA. gc-signaling cytokines induce a regulatory T cell (Treg) phenotype in malignant CD4 T lymphocytes. J Immunol 181(4):2506-12, 2008.

Avarbock AB, Loren AW, Park JY, Junkins-Hopkins JM, Choi J, Litzky LA, Rook AH. Lethal vascular leak syndrome after denileukin diftitox administration to a patient with cutaneous gamma/delta T-cell lymphoma and occult cirrhosis. Am J Hematol 83(7):593-5, 2008.

Robinson BW, Cheung N-KV, Kolaris CP, Jhanwar SC, Potter JW, Willman CL, Choi JK, Osheroff N, Felix CA. Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. Blood 111(7):3802-12, 2008.

Teachey DT, Seif AE, Brown VI, Bruno M, Bunte RM, Chang YJ, Choi JK, Fish JD, Hall J, Reid GS, Ryan T, Sheen C, Zweidler-McKay P, Grupp SA. Targeting Notch signaling in autoimmune and lymphoproliferative disease. Blood 111(2):705-714, 2008.

Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS. Phospholipase cbeta is critical for T cell chemotaxis. J Immunol 179(4):2223-7, 2007.

Yu X, Kong Y, Dore LC, Abdulmalik O, Katein AM, Zhou S, Choi JK, Gell D, Mackay JP, Gow AJ, Weiss MJ. An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis. J Clin Invest 117(7):1856-65, 2007.

Sevilla DW, Choi JK, Gong JZ. Mediastinal Adenopathy, Lung Infiltrates, and Hemophagocytosis: Unusual Presentation of Pediatric Anaplastic Large Cell Lymphoma Report of Two Cases. Amer J Clin Path 127(3):1-7, 2007.

Heltzer ML, Choi JK, Ochs HD, Sullivan KE, Torgerson TR, Ernst LM. A Potential Screening Tool for IPEX Syndrome. Ped Dev Pathol 10:98-105, 2007.

Zhao XF, Young KH, Frank D, Goradia A, Glotzbecker MP, Pan W, Kersun LS, Leahey A, Dormans JP, Choi JK. Pediatric Primary Bone Lymphoma - Diffuse Large B cell Lymphoma: morphologic and immunohistochemical characteristics of 10 cases. Amer J Clin Path 127(1):47-54, 2007.

Teachey DT, Obzut DA, Axsom K, Choi JK, Goldsmith KC, Hall J, Hulitt J, Manno CS, Maris JM, Rhodin N, Sullivan KE, Brown VI, Grupp SA. Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS). Blood 108(6):1965-71, 2006.

Glotzbecker MP, Kersun LS, Choi JK, Wills BP, Schaffer AA, Dormans JP. Primary Non-Hodgkin's Lymphoma of Bone in Children. Journal of Bone and Joint Surgery 88(3):583-594, 2006.

Teachey DT, Obzut DA, Cooperman J, Fang J, Carroll M, Choi JK, Houghton PJ, Brown VI, Grupp SA. The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Blood 107(3):1149-55, 2006.

Teachey DT, Manno CS, Axsom KM, Andrews T, Choi JK, Greenbaum BH, McMann JM, Sullivan KE, Travis SF, Grupp SA. Unmasking Evans Syndrome: T cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS). Blood 105(6):2443-8, 2005.

Talora C, Cialfi S, Segatto O, Morrone S, Choi JK, Frati L, Paolo Dotto G, Gulino A, Screpanti I. Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways. Exp Cell Res 305(2):343-54, 2005.

Armstrong G, Szallasi A, Biegel JA, Shurtleff SA, Bilaniuk LT, Womer RB, Choi JK. Early molecular detection of central nervous system relapse in a child with systemic anaplastic large cell lymphoma: case report and review of the literature. Pediatric Blood & Cancer 44(4):400-406, 2005.

Song S, Cooperman J, Letting DL, Blobel GA, Choi JK. Identification of cyclin D3 as a direct target of E2A using DamID. Mol Cell Biol 24(19):8790-802, 2004.

Shetzline SE, Rallapalli R, Dowd KJ, Zou S, Nakata Y, Swider CR, Kalota A, Choi JK, Gewirtz AM. Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. Blood 104(6):1833-40, 2004.

Shankar S, Choi JK, Dermody TS, Head DR, Bunin N, Iannone R. Pulmonary hypertension complicating bone marrow transplantation for idiopathic myelofibrosis. Pediatr Hematol Oncol 26(6):393-7, 2004.

Gitler AD, Kong Y, Choi JK, Pear WS, Epstein JA. Tie2 Cre-Induced Inactivation of a conditional mutant Nf1 allele results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatric Research 55(4):581-4, 2004.

Cooperman J, Neely R, Teachey DT, Grupp S, Choi JK. Cell Division Rates of Primary Human Precursor B Cells in Culture Reflect In Vivo Rates. Stem Cells 22(6):1111-20, 2004.

Choi JK>, Mauger J, McGowan KL. Immunohistochemical detection of Aspergillus species in pediatric tissue. Amer J Clin Path 121(1):18-25, 2004.

Last update: September 2012