Departmental Focus
The Chemical Biology and Therapeutics (CBT) Department was established to develop innovative chemical and chemoinformatic solutions to fundamental problems in biology and medicine. Present research programs include creation of novel chemical entities that trigger or inhibit gene expression, reveal single molecule and super-resolution images of cellular processes, target drug resistance in microbes and humans, and explore protein-ligand dynamics at physiological temperatures. In parallel, the collaborative centers that form the “Therapeutics” component of CBT provide chemical synthesis, high throughput and high content screening, and computational capabilities that match leading biotech/pharma operations and are rarely accessible at academic institutions.
The scientific research arm of CBT is in an exciting growth phase. We invite creative individuals with bold vision and demonstrated excellence in research at the interface of Chemistry, Biology and Medicine to apply for multiple faculty positions.
The CBT Catalyst
Chemical Biology and Therapeutics is pleased to announce the release of its first departmental newsletter, The CBT Catalyst. It contains important words on the accomplishments, endeavors, struggles and talents of our chemical biology community over the past year.
Past Events
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Transcription Therapy Symposium
09/24/2020
This symposium explored chemical approaches to elucidating and regulating chromatin and epigenetic landscapes, and mechanistically guided approaches to remedying dysfunctional gene regulation in human disease.
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2020 Chemical Biology and Therapeutics Symposium
09/25/2020
This symposium offered a broad survey of major advances in chemistry and biology and explored emerging questions in biomedical sciences that can be uniquely answered by chemical and computational approaches.
Contact Us
Department of Chemical Biology & Therapeutics
MS 1000, Room E9057
St. Jude Children's Research Hospital
262 Danny Thomas Place
Memphis, TN 38105-3678
Email:
SPCBTAdminOps@stjude.org
Phone: (901) 595-8087
Fax: (901) 595-5715
Preferred contact method: email
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Aseem Z. Ansari
Ansari
Synthetic genome regulators
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Daniel J. Blair, PhD
Blair
Covalent interactions between small molecules and proteins/RNA
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Scott C. Blanchard, PhD
Blanchard
Examining structure-function relationships in macromolecular assemblies
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Small-molecule transcription factor drug discovery
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Tommaso Cupido, PhD
Cupido
Chemical biology of protein machines
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Hai T. Dao, PhD
Dao
Chromatin dynamics during transcription
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Marcus Fischer, PhD
Fischer
Exploiting the protein conformational landscape for ligand discovery
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Development of new chemotherapeutic agents
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Anang A. Shelat, PhD
Shelat
Multi-scale modeling of biological and chemical data
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Julianne Bryan, PMP
Bryan
- Director, Chemical Biology Operations
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Natalie Racine
Racine
- Manager of Operations
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Lauren Sides
Sides
- Senior Administrative Assistant
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Candice Stokes
Stokes
- Senior Administrative Assistant
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