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Doralina Anghelescu, MD
Doralina Anghelescu, MD

Doralina Anghelescu, MD

Member, St. Jude Faculty

  • Director, Pain Management Service




MD – Bucharest University School of Medicine, Romania
Certificate in Business Administration – American Society of Anesthesiologists
Certification in Palliative Care Education and Practice – Harvard Medical School Center for Palliative Care

Research Interests

  • Neuropathic pain during treatment of acute lymphoblastic leukemia
  • Vaso-occlusive crisis pain in patients with sickle cell disease
  • Neuropathic pain after limb sparing surgery in patients with osteosarcoma
  • Safety of outpatient patient controlled analgesia
  • Patient controlled analgesia at the end of life
  • Pain management at the end of life and palliative sedation
  • Impact of psychological interventions for pain management during monoclonal antibodies infusions for pediatric cancer
  • Opioid abuse and misuse risk assessment and mitigation strategies

Selected Publications

Peck KR, Harman JL, Anghelescu DL. Provision of Adequate Pain Management to a Young Adult Oncology Patient Presenting with Aberrant Opioid-Associated Behavior: A Case Study. J Adolesc Young Adult Oncol Oct 18, 2018. doi: 10.1089/jayao.2018.0093. [Epub ahead of print]

Peters JB, Anghelescu DL, Conklin HM, Hall L, Means BL, Schreiber JE, Rossi M, Wright B, Gajjar A, Jacola LM. The Impact of Sedation for Radiation Therapy on Performance Measures and Caregiver Ratings of Attention in Survivors of Pediatric Medulloblastoma. Journal of the International Neuropsychological Society 23(S1):I-366, 2017. doi:10.1017/S1355617717000558

Jacola LM, Anghelescu DL, Hall L, White L, Russel K, Schreiber JE, Rossi M, Moore A, Gajjar A. The Relationship between Procedural Sedation during Treatment and Neurocognitive Outcomes in Survivors of Pediatric Medulloblastoma. Journal of the International Neuropsychological Society 23(S1):I-366, 2017. doi:10.1017/S1355617717000558

Gil S, Fernandez Pineda I, Rao B, Neel M, Wu H, Wu J, Baker J, Anghelescu DL, Role of Amputation in Improving the Quality of Life, Mobility and Pain Outcomes in Children with Metastatic Osteosarcoma. Am J Hosp Palliat Care Jul 29:1049909118791119, 2018. doi: 10.1177/1049909118791119. [Epub ahead of print] PMID: 30058346

Anghelescu DL, Brown CL, Murphy AJ, Davidoff AM, Dickson PV, Glazer ES, Stiles ZE, Bishop MW, Douthitt L, Deneve JL. Anesthesia and Pain Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumors in Children, Adolescents, and Young Adults. Annals of Surgical Oncology 2018 (in press).

Stiles ZE, Murphy AJ, Dickson PV, Anghelescu DL, Brown CL, Davidoff AM, Glazer ES, Bishop MW, Furman WM, Pappo AS, Lucas JT, Dobrouvin M, Munene G, Deneve JL. Desmoplastic Small Round Cell Tumor: Long-Term Complications after Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy. Annals of Surgical Oncology 2018 (in press).

Anghelescu DL, Pankayatselvan V, Nguyen R, Ward D, Wu J, Wu H, Edwards D, Furman W. Bisphosphonate use in pediatric oncology for pain management. Am J Hosp Palliat Care Aug 16:1049909118793114, 2018. doi: 10.1177/1049909118793114. [Epub ahead of print] PMID: 30114925

Anghelescu DL, Guo A, Morgan K, Frett M, Prajapati H, Gold R, Federico S. Pain Outcomes after Celiac Plexus Block in Children and Young Adults with Cancer. J Adolesc Young Adult Oncol Aug 16, 2018. doi: 10.1089/jayao.2018.0035. [Epub ahead of print]. PMID: 30113244

Habashy C, Springer E, Hall E, Anghelescu DL. Methadone for Cancer Pain in Children: A Review. Paediatr Drugs Oct;20(5):409-416, 2018. doi: 10.1007/s40272-018-0304-2. Review. PMID: 30047027

Kaddoum RK, Anghelescu DL, Wright BB, Aouad M. Randomized cross over study comparing the first attempt success rate of intravenous cannulation in children using the AccuVein AV 300 apparatus versus the standard technique. MEJA Oct 2018.

Puri L, Nottage KA, Hankins JS, Anghelescu DL. State of the Art Management of Vaso-occlusive Pain in Sickle Cell Disease. Paediatr Drugs Aug 29, 2017. doi: 10.1007/s40272-017-0263-z. [Epub ahead of print] Review.

Peck KR, Ehrentraut JH, Anghelescu DL. Family and Peer-Group Substance Abuse as a Risk-Factor Opioid Misuse Behaviors for a Young Adult with Cancer-Related Pain – A Case Study. J Adolesc Young Adult Oncol Sep 14, 2017. [Epub ahead of print]

Walker B, Conklin HM, Anghelescu DL, Ogg R, Reddick G, Jacola L. Feasibility and Acceptability of Nonsedated MRI Scans in a Pediatric Oncology Population: A Parent Survey. J Supportive Care in Cancer Dec 19, 2017. doi: 10.1007/s00520-017-4009-9.

Johnson LM, Frader J, Wolfe J, Baker J, Anghelescu DL, Lantos J. Ethics Rounds: Palliative sedation with propofol for an adolescent with a DNR order. Pediatrics Jul 5, 2017. pii: e20170487. doi: 10.1542/peds.2017-0487. [Epub ahead of print]

Morgan K, Pribnow A, Moore A, Anghelescu DL. A case of persistent intra-anesthetic hypotension related to chronic treatment with extended release beta blocker for psychiatric diagnoses. Annals of Psychiatry and Mental Health 5(2):1096, 2017.

Anghelescu DL, Knapp E, Johnson LM, Baker JN. The role of the pediatric anesthesiologist in relieving suffering at the end of life: When is palliative sedation appropriate in pediatrics. Paediatr Anaesth 27(4):443-444, 2017. doi: 10.1111/pan.13103

Morgan K, Anghelescu DL. A complete review of adult and pediatric neuropathic pain assessment tools. Clin J Pain Dec 28, 2016. doi: 10.1097/AJP.0000000000000476. [Epub ahead of print]

Moore A, Anghelescu DL. Emergence delirium – Review article. Paediatr Drugs 19(1):11-20, 2017. doi: 10.1007/s40272-016-0201-5

Anghelescu DL, Steen BD, Wu H, Wu J, Daw NC, Rao BN, Neel MD, Navid F. Prospective study of neuropathic pain after definitive surgery for extremity osteosarcoma in a pediatric population. Pediatr Blood Cancer Aug 30, 2016. doi: 10.1002/pbc.26162.

Snaman J, Baker JN, Anghelescu DL. Pediatric Oncology: Controlling pain at the end of life. Paediatr Drugs Mar 7, 2016. [Epub ahead of print] PMID: 26951239

Anghelescu DL, Kelly CN, Steen BD, Wu J. Wu H, DeFeo B, Scobey K, Burgoyne L. Retrospective review of mirror therapy for phantom limb pain at a pediatric oncology institution. Rehabil Oncol 34(3):104-110, 2016.

Anghelescu DL, Patel RM, Mahoney DP, Trujillo L, Faughnan LG, Steen BD, Baker JN, Pei D. Methadone prolongs cardiac conduction in young patients with cancer-related pain. J Opioid Manag 12(2):131-138, 2016. doi: 10.5055/jom.2016.0325

Kaddoum RK, Foz C, Ibrahim M, Anghelescu DA. A case report of acute opioid withdrawal following the discontinuation of a short-term epidural with fentanyl. Anaesthesia, Pain & Intensive Care

Nottage KA, Hankins JS, Faughnan LG, James DM, Richardson J, Christensen R, Kang G, Smeltzer M, Cancio MI, Wang WC, Anghelescu DL. Addressing challenges of clinical trials in acute pain: The Pain Management of Vaso-occlusive Crisis in Sickle Cell Disease Study (PMVOC). Clin Trials Mar 21, 2016. [Epub ahead of print] PMID: 27000103

Kaddoum RN, Anghelescu DL, Karam C, Aouad MT, Hitti E. The prescription opioid epidemic in developed and underdeveloped countries: Is there a happy medium? J Opioid Manag 12(2):93-95, 2016. doi: 10.5055/jom.2016.0319

Peck KR, Ehrentraut JH, Anghelescu DL. Risk factors for opioid misuse in adolescent and young adults with focus on oncology setting. J Opioid Manag 12(3):205-216, 2016. doi: 10.5055/jom.2016.0333.

Anghelescu DL, Zhang K, Faughnan LG, Pei D. The safety and effectiveness of patient-controlled analgesia in outpatient children and young adults with cancer: A retrospective study. J Pediatr Hematol Oncol 37(5):378-382, 2015. PMCID: PMC4683407

Vern-Gross TZ, Lam CG, Graff Z,  Singhal S, Levine D, Gibson D, Coan A, Anghelescu DL, Yuan Y, Baker JN. Patterns of end-of-life care in children with advanced solid tumor malignancies enrolled on a palliative care service. J Pain Symptom Manage 50(3):305-312, 2015. PMCID: PMC4550524

Baker NJ, Levine DR, Hinds PS, Weaver MS, Cunningham MJ, Johnson LM, Anghelescu D, Mandrell B, Gibson DV, Jones B, Wolfe J, Feudtner C, Freibert S, Carter B, Kane JR. Research priorities in pediatric palliative care: A Delphi study. J Pediatr 167(2):467-470, 2015. PMCID: PMC4516589

Anghelescu DL, Trujillo LH, Snaman JM, Coan A, Ying Y, Baker JR. Patient controlled analgesia at the end of life at a pediatric oncology institution. Pediatr Blood Cancer 62(7):1237-1244, 2015. PMCID: PMC4433603

Last update: December 2018