Elizabeth Azzato, MD, PhD, MPH
Elizabeth Azzato, MD, PhD

Elizabeth Azzato, MD, PhD

Assistant Member, St. Jude Faculty

  • Director, Molecular Pathology

Departments

Education

BA – Washington and Jefferson College, Washington, Pennsylvania
MPH – University of North Carolina, Chapel Hill, North Carolina
PhD – University of Cambridge, Cambridge, United Kingdom
MD – Duke University School of Medicine, Durham, North Carolina
Residency — Clinical Pathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Fellowship — Molecular Genetic Pathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

Fellowships and Awards

  • 2014 The William Pepper Fellowship Award, University of Pennsylvania

Research Interests

  • Molecular pathology and clinical genomics focusing on cancer diagnosis and prognosis
  • Translation of emerging molecular biomarkers and technologies into the clinical laboratory
  • Consolidation of genomic, transcriptomic and epigenomic data to clarify diagnoses and improve patient prognostication

Selected Publications

Azzato EM, Bagg A. Molecular genetic evaluation of myeloproliferative neoplasms. Int J Lab Hematol 37(Suppl 1):61-71, 2015. PMID: 25976962.

Azzato EM, Deshpande C, Aikawa V, Aggarwal C, Alley E, Jacobs B, Morrissette J, Daber R. Rare complex mutational profile in an ALK inhibitor-resistant non-small cell lung cancer. Anticancer Res 35(5):3007-12, 2015. PMID: 25964588.

Haspel RL, Rinder HM, Frank KM, Wagner J, Ali AM, Fisher PB, Parks ER; Training Residents in Genomics (TRIG) Working Group*. The current state of resident training in genomic pathology: a comprehensive analysis using the resident in-service examination. Am J Clin Pathol 142(4):445-51, 2014. PMID: 25239410. *Member of working group.

Azzato EM, Morrissette JJD, Halbiger R, Bagg A, Daber R. Development and implementation of a custom integrated database with dashboards to assist with hematopathology specimen triage and traffic. J Pathol Inform 5:29, 2014. PMID: 25250187.

Azzato EM, Deshpande C, Gabriel C, Langer, C, Evans T, Gault C, Morrissette JJD, Daber, R. MET mutations in non-small cell lung cancer: four case reports of mutations at or near the splice junction for exon 14. J OncoPathology 2(2):65, 2014.

Azzato EM, Edelstein PH, Watt CD. Molecular assays in HIV-1 diagnosis and therapeutic monitoring. CAP TODAY May 2014.

Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, Berndt SI, Boerwinkle E, Chanock S, Chatterjee N, Couper D, Curhan G, Heiss G, Hu FB, Hunter DJ, Jacobs K, Jensen MK, Kraft P, Landi MT, Nettleton JA, Purdue MP, Rajaraman P, Rimm EB, Rose LM, Rothman N, Silverman D, Stolzenberg-Solomon R, Subar A, Yeager M, Chasman DI, van Dam RM, Caporaso NE. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PloS Genet 7(4):e1002033, 2011. PMID: 21490707

Wishart GC, Bajdik CD, Azzato EM, Dicks E, Greenberg DC, Rashbass J, Caldas C, Pharoah PD. A population-based validation of the prognostic model PREDICT for early breast cancer. Eur J Surg Oncol 37(5):411-417, 2011. PMID: 21371853

Caporaso NE, Marti GE, Landgren O, Azzato E, Weinberg JB, Goldin L, Shanafelt T. Monoclonal B cell lymphocytosis: clinical and population perspectives. Cytometry B Clin Cytom 78(Suppl 1):S115-9, 2010. PMID: 20839332

Azzato EM, Lee AJX, Teschendorff AT, Ponder BAJ, Pharoah PDP, Caldas C, Maia A-T. Common germline polymorphism of C1qA and breast cancer survival. Br J Cancer 102(8):1294-9, 2010. PMID: 20332777.

Azzato EM, Pharoah PDP, Harrington P, Easton DF, Greenberg D, Caporaso NE, Chanock SJ, Hoover RN, Thomas G, Hunter DJ, Kraft P. A genome-wide association study of prognosis in breast cancer. Cancer Epidemiol Biomarkers Prev 19(4):1140-3, 2010. PMID: 20332263.

Azzato EM, Tyrer J, Fasching PA, Beckmann MW, Ekici AB, Schulz-Wendtland R , Bojesen SE, Nordestgaard BG, Flyger H, Milne RL, Arias JI, Menéndez P, Benítez J, Chang-Claude J, Hein R, Wang-Gohrke S, Nevanlinna H, Heikkinen T, Aittomäki K, Blomqvist C, Margolin S, Mannermaa A, Kosma V-M, Kataja V, kConFab, Beesley J, Chen X, Chenevix-Trench G, Couch FJ, Olson JE, Fredericksen ZS, Wang X, Giles GG, Severi G, Baglietto L, Southey MC, Devilee P, Tollenaar RAEM, Seynaeve C, García-Closas M, Lissowska J, Sherman ME, Bolton KL, Hall P, Czene K, Cox A, Brock IW, Elliott GC, Reed MWR, Greenberg D, Anton-Culver H, Ziogas A, Humphreys M, Easton DF, Caporaso NE, Pharoah PDP. Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer. J Natl Cancer Inst 102(9):650-62, 2010. PMID: 20308648.

Wischart GC*, Azzato EM*, Greenberg D, Rashbass J, Kearins O, Lawrence G, Caldas C, Pharoah PD. PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer. Breast Cancer Res 2010; 12(1):R1. PMID: 20053270. *Equal contributors.

Azzato EM, Chen RA, Wacholder S, Chanock SJ, Klebanoff MA, Caporaso NE. Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations. Pharmacogent Genomics 20(1):58-63, 2010. PMID: 19952982

Udler MS*, Azzato EM*, Healey CS, Ahmed S, Pooley KA, Greenberg D, Shah M, Teschendorff AE, Caldas C, Dunning AM, Ostrander EA, Caporaso NE, Easton D, Pharoah PD. Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. Int J Cancer 125(11):2687-96, 2009. PMID: 19551860. *Equal contributors.

Azzato EM, Greenberg D, Shah M, Blows F, Driver KE, Caporaso NE, Pharoah PD. Prevalent cases in observational epidemiological studies of cancer survival: do they bias hazard ratio estimates? Br J Cancer 100(11):1806-11, 2009. PMID: 19401693

Azzato EM, Morton LM, Bergen AW, Wang SS, Chatterjee N, Kvale P, Yeager M, Hayes, RB, Chanock SJ, Caporaso NE. SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. BMC Med Genet 10:9, 2009. PMID: 19183461.

Koessler T, Azzato EM, Perkins B, Greenberg D, Easton DF, Pharoah PD. Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer. Int J Cancer 124(8):1887-91, 2009. PMID: 19115210.

Pooley KA, Baynes C, Driver KE, Tyrer J, Azzato EM, Pharoah PD, Easton DF, Ponder BA, Dunning AM. Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk. Cancer Epidemiol Biomarkers Prev 17(12):3482-9, 2008. PMID: 19064565

Azzato EM, Driver KE, Lesueur F, Shah M, Greenberg D, Easton DF, Teschendorff AE, Caldas C, Caporaso NE, Pharoah PD. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. Breast Cancer Res 10(3):R47, 2008. PMID: 18507837.

Last update: August 2015