Mackenzie Bloom

Graduate Student

Departments

St. Jude Graduate School of Biomedical Sciences

Divisions

Cancer Predisposition Division

Education

BS- Biology (Genetics), University of Kansas, Lawrence, KS (2017)

Honors and Awards

2018-2019 St Jude Graduate Student of the Year
2016-2017 KINBRE STAR Trainee Fellow

Research Interests

I am a PhD candidate interested in hematopoietic stem cell (HSC) biology in both homeostatic and disease states. ETV6 is the most commonly mutated gene in childhood leukemia and recently germline variants have been identified that predispose individuals to hematologic malignancies. My thesis project focuses on understanding the role of the transcription factor, ETV6, in HSCs and how perturbation leads to hematopoietic diseases.

Selected Publications

Nishii R, Baskin-Doerfler R, Yang W, Oak N, Zhao X, Yang W, Hoshitsuki K, Bloom M, Verbist K, Burns M, Li Z, Lin TN, Qian M, Moriyama T, Gastier-Foster JM, Rabin KR, Raetz E, Mullighan C, Pui CH, Yeoh AE, Zhang J, Metzger ML, Klco JM, Hunger SP, Newman S, Wu G, Loh ML, Nichols KE, Yang JJ. Molecular basis of ETV6-mediated predisposition to childhood acute lymphoblastic leukemia. Blood Jan 21;137(3):364-373, 2021. doi: 10.1182/blood.2020006164. PMID: 32693409; PMCID: PMC7819760.

Bloom, M., Maciaszek, JL., Clark, ME., Pui, CH., Nichols, KE., Recent Advances in Genetic Predisposition to Pediatric Acute Lymphoblastic Leukemia. Expert Review of Hematology, Epub ahead of print, doi.org/10.1080/17474086.2020.1685866, 2019. Role: Co-First Author.

Last update: February 2021