Rachel C. Brennan, MD
Rachel C. Brennan, MD

Rachel C. Brennan, MD

Associate Member, St. Jude Faculty

Departments

Divisions

Education

BA – Carroll College, Helena, Montana
MD – Johns Hopkins University School of Medicine, Baltimore, Maryland
Internship/Residency (Pediatrics) – Johns Hopkins Hospital, Baltimore, Maryland
Fellowship (Pediatric Hematology/Oncology) – St. Jude Children’s Research Hospital

Research Interests

  • Retinoblastoma: therapy and late effects
  • Translating preclinical research into clinical trials (Lab Liaison)
  • Phase I clinical trials
  • Renal tumors
  • Minimizing early and late complications of chemotherapy

Selected Publications

Al-Haddad C, Bashour Z, Farah L, Bayram L, Merabe Z, Ma'luf R, Alameddine R, Eid T, Geara F, Wilson M, Brennan R, Jeha S, Ghanem K, Yousef RA, Farah R, Noun P, Yassine N, Inati A, Muwakkit S, Abboud M, Tarek N, Hamideh D, Saab R. Establishment of a formal program for retinoblastoma: Feasibility of clinical coordination across borders and impact on outcome. Pediatr Blood Cancer. 2019 Nov;66(11):e27959. doi: 10.1002/pbc.27959. Epub 2019 Aug 18.

Goldsmith ZK, Coppess W, Irvine AS, Yuan K, Barsh SR, Ritter MK, Mc#Ewen MW, Flores-Otero J, Garcia-Vargas A, Martinez-Ferrer M, Brennan RC, Morales-Tirado Vm, Wilson MW. Targeting the platelet-derived growth factor-beta stimulatory circuitry to control retinoblastoma seeds. Invest Ophthalmol Vis Sci. 2018 Sep 4; 59(11):4486-4495. Doi: 10.1167/iovs.18-24359.

Lucas JT, McGee R, Billups CA, Qaddoumi I, Merchant TE, Brennan RC, Wu J, Wilson MW. Prior non-irradiative focal therapies do not compromise the efficacy of delayed episcleral plaque brachytherapy in retinoblastoma. Br J Ophthalmol. 2018 June 28. Pii: bjophthalmol-2018-311923. Doi: 10.1136/bjophthalmol-2018-311923. [Epub ahead of print] PMID: 29954786 [PubMed – as supplied by publisher]

Webb AH, Gao BT, Goldsmith ZK, Irvine AS, Saleh N, Lee RP, Lendermon JB, Bheemreddy R, Zhang Q, Brennan RC, Johnson D, Steinle JJ, Wilson MW, Moralees-Tirado VM. Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma. BMC Cancer. 2017 Jun 20; 17(1):434. Doi: 10.1186/s12885-017-3418-y. PubMed Central PMCID: PMC5477686.

Millisor VE, Roberts JK, Sun Y, Tang L, Daryani VM, Gregornik D, Cross SJ, Ward D, Pauley JL, Molinelli A, Brennan RC, Stewart CF. Derivation of new equations to estimate glomerular filtration rate in pediatric oncology patients. Pediatr Nephrol. 2017 Sep;32(9):1575-1584. doi: 10.1007/s00467-017-3693-5. Epub 2017 Jun 2. PubMed Central PMCID: PMC5712286.

Interiano RB, McCarville MB, Santos ND, Mao S, Wu J, Dome JS, Kieran K, Williams MA, Brennan RC, Krasin MJ, Green DM, Davidoff AM. Comprehensive renal function evaluation in patients treated for synchronous bilateral Wilms tumor. J Pediatr Surg. 2017 Jan;52(1): 98-103. Doi: 10.1016/j.jpedsurg.2016.10.027. Epub 2016 Oct 27. PubMed Central PMCID: PMC5218869.

Brennan, RC, Qaddoumi I, Mao S, Wu J, Billups CA, Stewart C, Hoehn ME, Rodriguez-Galindo C, Wilson MW. Ocular salvage and vision preservation using a topotecan-based regimen for advanced intraocular retinoblastoma. J Clin Oncol  2017 Jan; 35(1): 72-77; Epub 2016 Oct 31. PubMed Central PMCID: PMC5455691.

Willard VW, Qaddoumi I, Zhang H, Huang L, Russell KM, Brennan R, Wilson MW, Rodriguez-Galindo C, Phipps S. A longitudinal investigation of parenting stress in caregivers of children with retinoblastoma. Pediatr Blood Cancer. 2017 April; 64(4). doi: 10.1002/pbc.26279. Epub 2016 Nov 3. PubMed Central PMCID: PMC5584625. [PubMed – indexed for MEDLINE]

Brennan RC, Qaddoumi I, Billups CA, Kaluzny T, Furman WL, Wilson MW. Patients with retinoblastoma and chromosome 13q deletions have increased chemotherapy-related toxicities. Pediatr Blood Cancer. 2016 Nov;63(11):1954-8. doi: 10.1002/pbc.26138. PubMed Central PMCID: PMC5683082.

Sparrow J, Brennan R, Mao S, Ness KK, Rodriguez-Galindo C, Wilson M, Qaddoumi I. Participation in an occupational therapy referral program for children with retinoblastoma. J Pediatr Rehabil Med. 2016 May 31;9(2):117-24. doi: 10.3233/PRM-160372. PubMed PMID: 27285804; PubMed Central PMCID: PMC4939593.

Davidoff AM, Interiano RB, Wynn L, Delos Santos N, Dome JS, Green DM, Brennan RC, McCarville MB, Krasin MJ, Kieran K, Williams MA. Overall survival and renal function of patients with synchronous bilateral wilms tumor undergoing surgery at a single institution. Ann Surg. 2015 Oct;262(4):570-576. PubMed Central PMCID: PMC5187953.

Brennan RC, Pritchard E, Guy R, Dyer M, Wilson M. Current and emerging therapy for improving outcomes in patients with intraocular retinoblastoma. Expert Opinion on Orphan Drugs. 06 Aug 2015:1155-1166.doi: 10.1517/21678707.2015.1075878. [Published online]

Brennan RC, Qaddoumi I, Billups CA, Free TL, Haik BG, Rodriguez-Galindo C, Wilson MW. Comparison of high-risk histopathological features in eyes with primary or secondary enucleation for retinoblastoma. Br J Ophthalmol. 2015 Apr 14. pii: bjophthalmol-2014-306364. doi: 10.1136/bjophthalmol-2014-306364. [Epub ahead of print] PubMed Central PMCID: PMC5148135.

Brennan RC, Furman W, Mao S, Wu J, Turner DC, Stewart CF, Santana V, McGregor LM. Phase I dose escalation and pharmacokinetic study of oral gefitinib and irinotecan in children with refractory solid tumors. Cancer Chemother Pharmacol. 2014 Dec; 74(6):1191-8. [Epub 2014 Sep 26] Pub Med Central PMCID: PMC4562671.

Brinkman TM, Merchant TE, Li Z, Brennan R, Wilson M, Hoehn ME, Qaddoumi I, Phipps S, Srivastava D, Robison LL, Hudson MM, Krull KR. Cognitive function and social attainment in adult survivors of retinoblastoma: a report from the St. Jude Lifetime Cohort Study. Cancer. 2015 Jan 1;121(1):123-31. doi: 10.1002/cncr.28924. Epub 2014 Nov 24. PubMed Central PMCID: PMC4270856.

Tse BC, Kaste SC, Brennan R, Orr B, Wilson MW. Enophthalmos and choroidal atrophy after intraophthalmic artery chemotherapy for retinoblastoma. Ophthalmology. 2014 Oct 22. [Epub ahead of print] PMID 25439599.

Willard VW, Qaddoumi I, Chen S, Zhang H, Brennan R, Rodriguez-Galindo C, Wilson MW, Phipps S. Developmental and adaptive functioning in children with retinoblastoma: A longitudinal investigation. J Clin Oncol. 2014 Sep 1; 32(25):2788-93. [Epub 2014 Jul 14] Pub Med Central PMCID: PMC4979168.

Sullivan EM, Wilson MW, Billups CA, Wu J, Merchant TE, Brennan RC, Haik BG, Shulkin B, Free TM, Given V, Rodriguez-Galindo C, Qaddoumi I. Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation. J Pediatr Hematol Oncol. 2014 Aug;36(6):e335-40. doi: 10.1097/MPH.0000000000000141. PubMed Central PMCID: PMC4108566.

McEvoy J, Nagahawatte P, Finkelstein D, Richards-Yutz J, Valentine M, Ma J, Mullighan C, Song G, Chen X, Wilson M, Brennan R, Pounds S, Becksfort J, Huether R, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Mardis ER, Wilson RK, Easton J, Zhang J, Downing JR, Ganguly A, Dyer MA. RB1 gene inactivation by chromothripsis in human retinoblastoma. Oncotarget. 2014 Jan 30;5(2):438-50. PubMed Central PMCID: PMC3964219.

Bhagat S, Bass J, Qaddoumi I, Brennan R, Wilson M, Wu J, Galindo CR, Paglialonga A, Tognola  G. Time-frequency analysis of transient-evoked otoacoustic emissions in children exposed to carboplatin chemotherapy. Audiol Neurootol 18(2):71-82, 2013.  PMCID: PMC3777667

McEvoy J, Ulyanov A, Brennan R, Wu G, Pounds S, Zhang J, Dyer MA. Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. PLoS One. 2012;7(8):e42739. doi: 10.1371/journal.pone.0042739. Epub 2012 Aug 20. PubMed Central PMCID: PMC3423419.

Qaddoumi I, Billups CA, Tagen M, Stewart CF, Wu J, Helton K, McCarville MB, Merchant TE, Brennan R, Free TM, Given V, Haik BG, Rodriguez-Galindo C, Wilson MW. Topotecan and vincristine combination is effective against advanced bilateral intraocular retinoblastoma and has manageable toxicity. Cancer. 2012 Nov 15;118(22):5663-70. doi: 10.1002/cncr.27563. Epub 2012 Apr 19. PubMed Central PMCID: PMC3413782.

Brennan RC, Wilson MW, Kaste S, Helton KJ, McCarville MB. US and MRI of pediatric ocular masses with histopathological correlation. Pediatr Radiol. 2012 Jun;42(6):738-49. doi: 10.1007/s00247-012-2374-6. Epub 2012 Mar 31. Review. PubMed Central PMCID: PMC3530407.

Zhang J, Benavente CA, McEvoy J, Flores-Otero J, Ding L, Chen X, Ulyanov A, Wu G, Wilson M, Wang J, Brennan R, Rusch M, Manning AL, Ma J, Easton J, Shurtleff S, Mullighan C, Pounds S, Mukatira S, Gupta P, Neale G, Zhao D, Lu C, Fulton RS, Fulton LL, Hong X, Dooling DJ, Ochoa K, Naeve C, Dyson NJ, Mardis ER, Bahrami A, Ellison D, Wilson RK, Downing JR, Dyer MA.  A novel retinoblastoma therapy from genomic and epigenetic analyses.  Nature. 2012 Jan 11;481(7381):329-34. doi: 10.1038/nature10733. PubMed Central PMCID: PMC3289956.

Federico S, Brennan R, Dyer MA. Childhood cancer and developmental biology a crucial partnership. Curr Top Dev Biol. 2011;94:1-13. doi: 10.1016/B978-0-12-380916-2.00001-2. PubMed Central PMCID: PMC3551576

McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011 Aug 16;20(2):260-75. doi: 10.1016/j.ccr.2011.07.005. PubMed Central PMCID: PMC3551581.

Brennan RC, Federico S, Bradley C, Zhang J, Flores-Otero J, Wilson M, Stewart C, Zhu F, Guy K, Dyer MA. Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a. Cancer Res. 2011 Jun 15;71(12):4205-13. doi: 10.1158/0008-5472.CAN-11-0058. Epub 2011 Apr 22. PubMed Central PMCID: PMC3116943.

Brennan R, Federico S, Dyer MA. The war on cancer: have we won the battle but lost the war? Oncotarget. 2010 Jun;1(2):77-83. PubMed Central PMCID: PMC2945373.

Last update: October 2019