Education
BS – Union College, Albany New York
MD – Albany Medical College, Albany, New York
MS – Union Graduate College, Schenectady, New York
Internship/Residency (Pediatrics) – Johns Hopkins Hospital, Baltimore, Maryland
Fellowship (Pediatric Hematology/Oncology) – St. Jude Children’s Research Hospital
Honors & Awards
- 2016 St. Jude Children’s Research Hospital Teaching Award
Research Interests
- Protocol development and clinical investigations in Hodgkin Lymphoma
- Genetic causes of childhood cancer
- International collaboration and protocol development
Clinical Interests
- Hodgkin lymphoma
Selected Publications
JE Flerlage. Radiotherapy is here to stay. Blood Sept 28;140(10):1053-1054, 2022. PMID: 36074534
JE Flerlage, JR Myers, JL Maciaszek, N Oak, SR Rashkin, Y Hui, YD Wang, W Chen, G Wu, TC Chang, K Hamilton, LR Goldin, ML McMaster, M Rotunno, N Caporaso, A Vogt, F Flamish, K Wyatt, J Liu, M Tucker, C Mullighan, KE Nichols, ML Metzger, J Yang, E Rampersaud. Discovery of novel predisposing coding and noncoding variants in familial Hodgkin lymphoma. Blood Aug 17;blood.2022016056, 2022. PMID: 35977101
Lo AA, Major A, Super L, Appel B, Shankar A, Constine LS, Marks LJ, Kelly KM, Metzger ML, Buhtoiarov I, Mauz-Körholz C, Braz AR, Binkley MS, Flerlage J. Practice patterns for the management of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL): An international survey by GLOW. Leuk Lymph March 31;1-4, 2022. PMID: 35357263
Hall MD, Terezakis SA, Lucas JT, Gallop-Evans E, Dieckmann K, Constine LS, Hodgkin D, Flerlage JE, Metzger ML, Hoppe BS. Radiation Therapy Across Pediatric Hodgkin Lymphoma Research Group Protocols: A Report From the Staging, Evaluation, and Response Criteria Harmonization (SEARCH) for Childhood, Adolescent, and Young Adult Hodgkin Lymphoma (CAYAHL) Group. Int J Radiat Oncol Biol Phys Feb 1;112(2):317-334, 2022. PMID: 34390770
Avutu V, Monga V, Mittal N, Saha A, Andolina JR, Bell DE, Fair DB, Flerlage JE, et al. Use of Communication Technology to Improve Clinical Trial Participation in Adolescents and Young Adults with Cancer: Consensus Statement from Children’s Oncology Group Responsible Investigator Network. JCO Oncology Practice Mar;18(3):224-231, 2021. PMID: 34905405
Boucher A, Caldwell KJ, Crispino JD, Flerlage JE. Clinical and biological aspects of myeloid leukemia in Down syndrome. Leukemia Dec;35(12):3352-3360, 2021. PMID: 34518645
Kahn JM, Maguire FB, Li Q, Abrahao R, Flerlage JE, Alvarez E, Keegan THM. Initial cancer treatment and survival in children, adolescents, and young adults with Hodgkin lymphoma: A population-based study. Cancer Dec 15;127(24):4613-4619, 2021. PMID: 34494662
Ehrhardt MJ, Flerlage JF, Armenian S, Castellino SM, Hodgs, DC, Hudson, MM. Integration of Hodgkin Treatment and Late Effects Guidelines: Seeing the Forrest Beyond the Trees. JNCCN Jun 30;19(6):755-764, 2021. PubMed PMID: 34214967
Flerlage JE. Improving Care for All Pediatric Patients With Hodgkin Lymphoma. J Natl Compr Canc Netw Jun 30;19(6):733-754, 2021. PMID: 34214968
Flerlage JE, Hiniker SM, Armenian S, et al. NCCN Clinical Practice Guidelines in Oncology: Pediatric Hodgkin Lymphoma. Version 3.2021. J Natl Compr Canc Netw Jun 30;19(6):733-754, 2021. PMID: 34214968
Metzger ML, Link MP, Billett AL, Flerlage J, Lucas JL, Mandrell BN, Ehrhardt MJ, Bhakta N, Yock TI, Friedmann AM, de Alarcon P, Luna-Fineman S, Larsen E, Kaste SC, Shulkin B, Lu A, Chen L, Hiniker SM, Donaldson SS, Hudson MM, Krasin JK. Excellent Outcome for Pediatric Patients With High-Risk Hodgkin Lymphoma Treated With Brentuximab Vedotin and Risk-Adapted Residual Node Radiation. J Clin Oncol Jul 10;39(20):2276-2283, 2021. PMID: 33826362
Morgan KJ, Mohan R, Karol S, Flerlage J. Epidural blood patch for post-dural puncture headaches in adult and paediatric patients with malignancies: a review. Br J Anaesth Jun;126(6):1200-1207, 2021. PMID: 33612247
Hagleitner MM, Metzger ML, Flerlage JE, Kelly KM, Voss SD, Klug R, Kurch L, Cho S, Mauz-Koerholz C, Beishuizen A. Liver Involvement in Pediatric Hodgkin Lymphoma: A Systematic Review by an international collaboration on Staging Evaluation and Response Criteria Harmonization (SEARCH) for Children, Adolescent and Young Adult Hodgkin Lymphoma (CAYAHL). Pediatr Blood Cancer Aug;67(8):e28365, 2020. PMID: 32491274
Seelisch J, De Alarcon PA, Flerlage JE, Hoppe BS, Kaste SC, Kelly KM, Kurch L, Marks L, Mauz-Koerholz C, McCarten K, Metzger ML, Stroevesandt D, Voss SD, Punnett A. Expert Consensus Statements for Waldeyer's Ring involvement in Pediatric Hodgkin lymphoma: The Staging, Evaluation, and Response Criteria Harmonization (SEARCH) for Childhood, Adolescent and Young Adult Hodgkin lymphoma (CAYAHL) Group. Pediatr Blood Cancer Jul;67:e28361, 2020. PMID: 32672879
Lewis J, McCarten K, Kurch L, Flerlage JE, et al. Definition of cortical bone involvement in the staging of newly diagnosed pediatric Hodgkin lymphoma: A report from the International Working Group on Staging Evaluation and Response Criteria Harmonization (SEARCH). Pediatr Blood Cancer Apr;67(4), 2020. PMID: 31867838
Talleur AC, Flerlage JE, Shook DR, Chilsen AM, Hudson MM, Cheng C, Huang S, Triplett BM. Autologous hematopoietic cell transplantation for the treatment of relapsed/refractory pediatric, adolescent, and young adult Hodgkin lymphoma: a single institutional experience. Bone Marrow Transplant Jul;55(7):1357-1366, 2020. PMID: 32273588
Gartrell J, Kaste S, Sandlund J, Flerlage J, et al. The association of mediastinal mass in the formation of thrombi in pediatric patients with non-lymphoblastic lymphomas. Pediatr Blood Cancer Feb;67(2), 2020. PMID: 31736198
Flerlage JE, von Buttlar X, Krasin M, Triplett B, Kaste SC, Metzger ML. Brentuximab Vedotin as Consolidation after Hematopoetic Cell Transplant for Relapsed Hodgkin Lymphoma in Pediatric Patients. Pediar Blood Cancer Dec;66(12):e27962, 2019. PMID: 31429511
Tinkle CL, Williams NL, Huiyan W, Wu J, Kaste SC, Shulkin BL, Talleur AC, Flerlage JE, Hudson MM, Metzger ML, Krasin MJ. Treatment patterns and disease outcomes for pediatric patients with refractory or recurrent Hodgkin lymphoma treated with curative-intent salvage radiotherapy. Radiotherapy and Oncology May;134:89-95, 2019. PMID: 31005229
Leventaki V, Flerlage J. Sarcoid-like granulomatosis in a patient receiving anti-TNFα for psoriasis. Am J Hematol 93(5):722-723, 2018. PMID: 29274117
Flerlage, JE, Kelly K, Beishuizen A, et al. Staging Evaluation and Response Criteria Harmonization (SEARCH) for Childhood, Adolescent and Young Adult Hodgkin Lymphoma (CAYAHL): Methodology Statement. Pediatr Blood Cancer 64:1-10, 2017. PMID: 28097818
Flerlage JE, Metzger M, Wu J, Panetta C. Pharmacokinetics, Immunogenicity, and Safety of Weekly Dosing of Brentuxima24b in Pediatric Patients with Hodgkin Lymphoma. Cancer Chemother Pharmacol 78:1217-1223, 2016. PMID: 27837256
Flerlage, JE, Baker JN. Methylnaltrexone for Opioid-Induced Constipation in Children and Adolescents and Young Adults with Progressive Incurable Cancer at the End of Life. J Palliat Med 18:631-633, 2015. PMID: 25927665
Laubisch, JE, Baker JN, Methylnaltrexone use in a 17-Month-Old Female with Progressive Cancer and Rectal Prolapse. J Palliat Med 16:1486-1488, 2013. PMID: 23746197
Laubisch JE, Green DM, Mogayzel PJ, Reid Thompson W. Treatment of plastic bronchitis by orthotopic heart transplantation. Pediatr Cardiol 32:1193-1195, 2011. PMID: 21479821
Last update: December 2022