Claudia M. Hillenbrand, PhD
Claudia M. Hillenbrand, PhD

Claudia M. Hillenbrand, PhD

Associate Member, St. Jude Faculty




PhD – Julius-Maximilians-University and University Hospitals of Würzburg, Würzburg, Germany

Research Interests

  • Translational imaging research with focus on magnetic resonance (MR) physics
  • Development of non-invasive, quantitative MR tests to guide therapy, assess therapeutic response, and to characterize effects of disease
  • MR-based organ function tests
  • Iron overload
  • Novel MR imaging in hemoglobinopathies

Selected Publications

Tipirneni-Sajja A, Krafft AJ, McCarville MB, Loeffler RB, Song R, Hankins JS, Hillenbrand CM. Radial UTE Imaging Removes the Need for Breath-holding in Hepatic Iron Overload Quantification by R2*-MRI. AJR Am J Roentgenol Epub 2017 May 15:1-8. PMID: 28504544

Krafft AJ, Loeffler RB, Song R, Tipirneni-Sajja A, McCarville MB, Robson MD, Hankins JS, Hillenbrand CM. Quantitative ultrashort echo time imaging for assessment of massive iron overload at 1.5 and 3 Tesla. Magn Reson Med Epub 2017 Jan 16. PMID: 28090666

Loeffler RB, McCarville MB, Wagstaff AW, Smeltzer MP, Krafft AJ, Song R, Hankins JS, Hillenbrand CM. Can Multi-slice or Navigator-gated R2*-MRI Replace Single-slice Breath-hold Acquisition for Hepatic Iron Quantification? Pediatr Radiol Epub 2016 Oct 17. PMID: 27752732

Mitrea BG, Krafft AJ, Song R, Loeffler RB, Hillenbrand CM. Paired self-compensated spin-lock preparation for improved T1ρ quantification. J Magn Reson Jul;268:49-57, 2016. Epub 2016 Apr 30. PMID: 27161095

Tipirneni-Sajja A, Loeffler RB, Oesingmann N, Bissler J, Song R, McCarville B, Jones DP, Hudson M, Spunt SL, Hillenbrand CM. Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific two-compartment model. Physiol Rep Apr;4(7), 2016. PMID: 2708116

Krafft AJ, Loeffler RB, Song R, Bian X, McCarville MB, Hankins JS, Hillenbrand CM. Does fat suppression via chemically selective saturation affect R2*-MRI for transfusional iron overload assessment? A clinical evaluation at 1.5T and 3T. Magn Reson Med Aug;76(2):591-601, 2016. Epub 2015 Aug 26. PMID: 26308155

Sabin ND, Santucci AK, Klimo P Jr, Hudson MM, Srivastava D, Zhang N, Kun LE, Krasin MJ, Pui CH, Patay Z, Reddick WE, Ogg RJ, Hillenbrand CM, Robison LL, Krull KR, Armstrong GT. Incidental detection of late subsequent intracranial neoplasms with magnetic resonance imaging among adult survivors of childhood cancer. J Cancer Surviv Sep;8(3):329-35, 2014. PMID: 24488818

Winchell AM, Taylor BA, Song R, Loeffler RB, Grundlehner P, Hankins JS, Wang WC, Ogg RJ, Hillenbrand CM, Helton KJ. Evaluation of SWI in Children with Sickle Cell Disease. AJNR Am J Neuroradiol May;35(5):1016-21, 2014. PMID: 24263696.

Panandiker AS, Winchell A, Loeffler R, Song R, Rolen M, Hillenbrand C. 4DMRI Provides More Accurate Renal Motion Estimation in IMRT in Young Children. Pract Radiat Oncol Apr-Jun;3(2 Suppl 1):S1, 2013.  PMID: 24674469

Armstrong GT, Reddick WE, Petersen RC, Santucci A, Zhang N, Srivastava D, Ogg RJ, Hillenbrand CM, Sabin N, Krasin MJ, Kun L, Pui CH, Hudson MM, Robison LL, Krull KR. Evaluation of Memory Impairment in Aging Adult Survivors of Childhood Acute Lymphoblastic Leukemia Treated With Cranial Radiotherapy. J Natl Cancer Inst Jun 19;105(12):899-907, 2013. PMID:23584394.

Sedlacik J, Winchell A, Kocak M, Loeffler RB, Broniscer A, Hillenbrand CM. MR Imaging Assessment of Tumor Perfusion and 3D Segmented Volume at Baseline, during Treatment, and at Tumor Progression in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma. AJNR Am J Neuroradiol 34(7):1450-5, 2013. PMID:23436052.

Taylor BA, Loeffler RB, Song R, McCarville MB, Hankins JS, Hillenbrand CM. Automated T2* Mapping with Susceptibility Removal to Assess Cardiac Iron Content. J Magn Reson Imaging Aug;38(2):441-7, 2013. PMID:23292658.

Sedlacik J, Myers A, Loeffler RB, Williams RF, Davidoff AM, Hillenbrand CM. A Dedicated Injection System for Reproducible and Reliable Dynamic Contrast-Enhanced MRI Experiments in Mice. J Magn Reson Imaging Mar;37(3):746-51, 2013. PMID: 23001593.

Taylor BA, Loeffler RB, Song R, McCarville MB, Hankins JS, Hillenbrand CM. Simultaneous Field and R2* Mapping to Quantify Liver Iron Content Using Autoregressive Moving Average Modeling. J Magn Reson Imaging May;35(5):1125-32, 2012. PMID: 22180325

Hillenbrand CM, Reykowski A. MR Imaging of the Newborn: A Technical Perspective. Magn Reson Imaging Clin N Am Feb;20(1):63-79, 2012. PMID: 22118593

Song R, Loeffler RB, Hillenbrand CM. QUIPSS II with window-sliding saturation sequence (Q2WISE).Magn Reson Med Sep 27, 2011. doi: 10.1002/mrm.23093. PMID: 21954083

Teitz T, Stanke JJ, Federico S, Bradley CL, Brennan R, Zhang J, Johnson MD, Sedlacik J, Inoue M, Zhang ZM, Frase S, Rehg JE, Hillenbrand CM, Finkelstein D, Calabrese C, Dyer MA, Lahti JM. Preclinical Models for Neuroblastoma: Establishing a Baseline for Treatment. PLoS One Apr 29;6(4):e19133, 2011.

Löbel U, Sedlacik J, Reddick WE, Kocak M, Ji Q, Broniscer A, Hillenbrand CM, Patay Z. Quantitative Diffusion-Weighted and Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Analysis of T2 Hypointense Lesion Components in Pediatric Diffuse Intrinsic Pontine Glioma. AJNR Am J Neuroradiol 32(2):315-22, 2011.

Song R, Tipirneni A, Johnson P, Loeffler RB, Hillenbrand CM. Evaluation of respiratory liver and kidney movements for MRI navigator gating. J Magn Reson Imaging 33(1):143-8, 2011.

Löbel U, Sedlacik J, Sabin ND, Kocak M, Broniscer A, Hillenbrand CM, Patay Z. Three-dimensional susceptibility-weighted imaging and two-dimensional T2*-weighted gradient-echo imaging of intratumoral hemorrhages in pediatric diffuse intrinsic pontine glioma. Neuroradiology 52(12):1167-77, 2010.

Hankins JS, McCarville BM, Hillenbrand CM, Loeffler, RB, Ware RE, Song R, Smeltzer MP, Joshi V. Ventricular diastolic dysfunction in sickle cell anemia is common but not associated with myocardial iron deposition. Pediatr Blood Cancer 55(3):495-500, 2010.

Song R, Loeffler RB, Hillenbrand CM. Improved renal perfusion measurement with a dual navigator-gated Q2TIPS FAIR technique. Magn Reson Med Nov;64(5):1352-9, 2010.

Choli M, Jakob PM, Loeffler RB, Hillenbrand CM. Mixed-Bandwidth Acquisitions: Signal-to-Noise Ratio and Signal-to-Noise efficiency. J Magn Reson Imaging 32(4):997-1002, 2010.

Hankins JS, Smeltzer MP, Beth McCarville M, Aygun B, Hillenbrand CM, Ware RE, Onciu M. Patterns of liver iron accumulation in sickle cell disease and thalassaemia patients with iron overload. Eur J Haematol 85(1):51-7, 2010.

McCarville MB, Hillenbrand CM, Loeffler RB, Smeltzer MP, Song R, Li CS, Hankins JS. Comparison of whole liver and small region-of-interest measurements of MRI liver R2* in children with iron overload. Pediatr Radiol 40(8):1360-7, 2010.

Sedlacik J, Löbel U, Kocak M, Loeffler RB, Reichenbach JR, Broniscer A, Patay Z, Hillenbrand CM. Attenuation of cerebral venous contrast in susceptibility-weighted imaging of spontaneously breathing pediatric patients sedated with propofol. Am J Neuroradiol 31(5):901-6, 2010.

Hankins JS, McCarville MB, Loeffler RB, Smeltzer MP, Onciu M, Hoffer FA, Li C-S, Wang WC, Ware RE, Hillenbrand CM. R2* magnetic resonance imaging of the liver in patients with iron overload.Blood 113(20), 4853-5, 2009. PMID: 19264677. PMCID: PMC2686136.

Frericks BB, Elgort DR, Hillenbrand C, Duerk JL, Lewin JS, Wacker FK. Magnetic resonance imaging-guided renal artery stent placement in a Swine model: comparison of two tracking techniques. Acta Radiol 50(1), 21-27, 2009. PMID: 19101851.

Show More

Zhang S, Rafie S, Chen Y, Hillenbrand CM, Wacker FK, Duerk JL, Lewin IS. In vivo cardiovascular catheterization under real-time MRI guidance. J Magn Reson Imaging 24(4):914-7, 2006.

Salvado O, Hillenbrand C, Zhang S, Wilson DL. Method to correct intensity inhomogeneity in MR images for atherosclerosis characterization. IEEE Trans Med Imaging 25(5):539-552, 2006.

Salvado O, Hillenbrand CM, Wilson DL. Partial volume reduction by interpolation with reverse diffusion. Int J Biomed Imaging Article ID 92092, 1-13, 2006.

Elgort DR, Hillenbrand CM, Zhang S, Wong EY, Rafie S, Lewin JS, Duerk JL. Image guided and monitored renal artery stenting using only MRI. J Magn Reson Imaging 23(5):619-627, 2006.

Hillenbrand CM, Jesberger JA, Wong EY, Zhang S, Chang DT, Wacker FK, Lewin JS, Duerk JL. Toward rapid high resolution in vivo intravascular MRI: Evaluation of vessel wall conspicuity in a porcine model using multiple imaging protocols. J Magn Reson Imaging 23(2):135-144, 2006.

Wacker FK, Hillenbrand C, Elgort DR, Zhang S, Duerk JL, Lewin JS. MR imaging-guided percutaneous angioplasty and stent placement in a swine model comparison of open- and closed-bore scanners. Acad Radiol 12(9):1085-1088, 2005.

Wacker FK, Hillenbrand CM, Duerk JL, Lewin JS. MR-guided endovascular interventions: Device visualization, tracking, navigation, and clinical applications. Magn Reson Imaging Clin N Am13(3):431-439, 2005.

Salvado O, Hillenbrand C, Suri J, Wilson DL. MR coil sensitivity inhomogeneity correction for plaque characterization in carotid arteries. Proc SPIE 5370:2114-2121, 2004.

Wacker FK, Elgort D, Hillenbrand CM, Duerk JL, Lewin JS. The Catheter-Driven MR Scanner: A New Approach to Intravascular Catheter Tracking and Imaging Parameter Adjustment for Interventional MR Imaging. AJR Am J Roentgenol 183(2):391-5, 2004.

Boll DT, Hillenbrand CM, Lewin JS, Merkle EM. Assessment of Parallel Acquisition Techniques in Adrenal MR Imaging: Does Increased Temporal Resolution Significantly Improve Visualization and Characterization of Adrenal Lesions? Acad Radiol 11(7):809-16, 2004.

Hillenbrand CM, Elgort DR, Wong EY, Reykowski A, Wacker FK, Lewin JS, Duerk JL. Active device tracking and high resolution intravascular MRI using a novel catheter based, opposed solenoid phased array coil. Magn Reson Med 51(4):668-75, 2004.

Elgort DR, Wong EY, Hillenbrand CM, Wacker FK, Lewin JS, Duerk JL. Real-time Catheter Tracking and Adaptive Imaging. J Magn Reson Imaging 18(5), 621-626, 2003.

Dale BM, Jesberger JA, Lewin JS, Hillenbrand CM, Duerk JL. Determining and Optimizing the Precision of Quantitative Measurements of Perfusion from Dynamic Contrast Enhanced MRI, J Magn Reson Imaging 18(5);575-84, 2003.

Nour SG, Lewin J, Gutman M, Hillenbrand C, Wacker FK, Mitchell IC, Armstrong C, Hashim M, Duerk JL, Strauss M. Percutaneous MR-Guided Technique For Radiofrequency Interstitial Thermal Ablation (RF-ITA) of The Porcine Tongue Base: Implication For Obstructive Sleep Apnea (OSA) Syndrome. Radiology 230(2):359-68, 2004.

Wacker FK, Wendt M, Ebert W, Hillenbrand C, Wolf KJ, Lewin JS. Use of a Blood-Pool Contrast Agent for MR-Guided Vascular Procedures: Feasibility of Ultra-small Superparamagnetic Iron Oxide Particles. Acad Radiol 9(11), 1251-1254, 2002.

Jakob PM, Hillenbrand CM, Kenn W, Hahn D, Haase A. Abdominal imaging with a modular combination of spin and gradient echoes. Magn Reson Med 47(3), 425-432, 2002.

Jakob PM, Hillenbrand CM, Wang T, Schultz G, Hahn D, Haase A. Rapid quantitative lung 1H T1 mapping. J Magn Reson Imaging 14(6), 795-799, 2001.

Jakob PM, Griswold M, Hillenbrand C, Heidemann R, Hahn D, Haase A. High speed and high resolution cardiac MRI (parallel acquisition techniques & modular imaging). MAGMA 11(1-2), 52-54, 2000.

Seifert MHJ, Jellus V, Haase A, Jakob PM, Hillenbrand C. High resolution Diffusion Imaging Using a Radial Turbo-Spin-Echo Sequence: Implementation, Eddy Current Compensation and Self-Navigation. J Magn Reson 144(2), 243-254, 2000.

Hillenbrand C, Hahn D, Haase A, Jakob PM. MR CAT Scan: A New Modular Approach for Hybrid Imaging. MAGMA 10(3), 183-99, 2000.

Hillenbrand C, Sandstede J, Pabst T, Hahn D, Haase A, Jakob PM. Hybrid Cardiac Imaging With MR CAT Scan. A Feasibility Study. J Magn Reson Imaging 11(6), 711-716, 2000.

Last update: June 2017