Kathleen J. Helton, MD
Kathleen J. Helton, MD

Kathleen J. Helton, MD

Member, St. Jude Faculty



MS – University of Tennessee School of Nursing, Memphis
MD – University of Tennessee School of Medicine, Memphis

Research Interests

  • Vasculopathy, DTI of white matter, ASL perfusion, structural/functional connectomes and fMRI in children with sickle cell anemia
  • The effect of tumor formation and chemotherapy on the structural and functional development of the visual system in children with retinoblastoma

Selected Publications

Alvarez O, Nottage K, Simpson LM, Wood J, Davis BR, Fuh B, Sarnaik S, Aygun B, Helton KJ, and Ware RE. Kidney Function of Transfused Children with Sickle Cell Anemia: Baseline Data from the TWiTCH Study and Comparison to Non-Transfused Cohorts. American Journal of Hematology 2017 (in press).

Helton KJ*, Patterson AL,* Khan RB, Sadighi Z. Two cases of cerebellar mutism in patients with non-central nervous system cancer. Journal of Child Neurology 2017 (in press).

Maller VV, Bathla G, Moritani T, Helton KJ. Imaging in viral infections of the central nervous system: can images speak for an acutely ill brain? Emerg Radiol Jun;24(3):287-300, 2017. doi10.1007/s10140-016-1463-5. Epub 2016 Nov 16.

Helton KJ, Maron GM, Mamcarz E, Patay Z, Sadighi Z. Unusual magnetic resonance imaging presentation of post BMT cerebral toxoplasmosis masquerading as meningoencephilitis and ventriculitis.  Bone Marrow Transplant Nov;51(11):1533-1536, 2016.

Nottage KA, Ware RE, Aygun B, Smeltzer M, Wang WC, Hankins JS, Helton KJ. Hydroxyurea prevents progression of silent infarctions in children with sickle cell anemia. Br J Haematol Oct;175(2):331-338, 2016.

Ware RE, Davis BR, Schultz WH, Brown RC, Aygun B, Sarnaik S, Odame I, Fuh B, George A, Owen W, Luchtman-Jones L, Rogers ZR, Hilliard L, Gauger C, Piccone C, Lee MT, Kwiatkowski JL, Jackson S, Miller ST, Roberts C, Heeney MM, Kalfa T, Nelson S, Imran H, Nottage K, Alvarez O, Rhodes M, Thompson AA, Rothman J, Helton KJ, Roberts D, Coleman J, Bonner MJ, Kutlar A, Patel N, Wood J, Piller L, Wei P, Luden J, Mortier NA, Stuber SE, Luban NLC, Cohen AR, Pressel S, Adams RJ. TCD With Transfusions Changing to Hydroxyurea (TWiTCH). Lancet Dec 4;S0140-6736(15):01041-7, 2015. doi: 10.1016/S0140-6736(15)01041-7.

Cancio M, Helton KJ, Schreiber J, Smeltzer M, Kang G, Wang W. Silent cerebral infarct in very young children with sickle cell anaemia are associated with a higher risk of stroke. Br J Haematol 171(1):120-129, 2015.

King BA, Parra C, Li Y, Helton KJ, Qaddoumi I, Wilson MW, Ogg R. Spatiotemporal patterns of tumor occurrence in children with intraocular retinoblastoma. PLos One 10(7):e0132932, 2015. PMCID: PMC4521796

Helton KJ, Glass J, Paydir A, Zandieh A, Dave R, Reddick WE, Ogg R. Comparing segmented ASL perfusion of vascular territories using manual vs. semi-automated techniques in children with sickle cell anemia. J Magn Reson Imaging 41(2):439-446, 2015.  PMCID: PMC4528912  doi: 10.1002/jmri.24559. Epub 2014 Jan 8

Helton KJ, Adams R,  Aygun B, Brown C, Daeschner C, Driscoll C, Heeney M, Helms R, Jackson S, Kwiatkowski J, Lee M, Yovetich N,  Garro J,  Driscoll C, Krishnamurthi L, Miller S, Sarnaik S, Schultz W, Ware R. Magnetic resonance imaging, angiography, and transcranial doppler velocities in sickle cell anemia: Results from the SWiTCH trial. Blood 124(6):891-898, 2014. PMCID: PMC4126329 doi: 10.1182/blood-2013-12-545186.

Winchell AM, Taylor B, Grundlehner P, Loeffler RB, Hankins J, Wang W, Hillenbrand CM, Helton KJ.  Evaluation of susceptibility weighted imaging in children with sickle cell disease. Am J Neuroradiol 35(5):1016-1021, 2014. PMCID: PMC4024339

Duffner PK, Armstrong FS, Chen L, Helton KJ, Brecher ML, Bell B, Chavenut AR. Neurocognitive and neuroradiologic central nervous system late effects in children treated on Pediatric Oncology Group (POG) P9605 (Standard Risk) and P9201 (Lesser Risk) Acute Lymphoblastic Leukemia Protocols (ACCL0131): A methotrexate consequence? A report from the Children’s Oncology Group. J Pediatr Hematol Oncol 36(1):8-15, 2014. PMCID: PMC4465396

Sansgari R, Wilson M, McCarville B, Helton KJ. Imaging, clinical and pathological features of pediatric medulloepithelioma: Four cases and a review of the literature. Pediatr Radiol 43(10):1344-1356, 2013. PMID: 23989751

Harreld J, Helton KJ, Kaddoum R, Reddick W, Li Y, Glass J, Sansgiri R, Ji Q, Feng T, Parish M, Gajjar A, Patay Z. The effects of propofol on cerebral perfusion MRI in children. Neuroradiology 55(8):1049-1056, 2013. PMCID: PMC3720819

DeWire M, Beltran C, Boop FA, Helton KJ, Ellison DW, McKinnon P, Gajjar A, Pai-Panandiker A.  Radiation therapy and adjuvant chemotherapy in a patient with a malignant glioneuronal tumor and underlying ataxia telangiectasia: a case report and review of the literature. J Clin Oncol 31(1):e12-14, 2013. PMCID: PMC4881371

Qaddoumi I, Billups C, Stewart CF, Wu J, Helton KJ, McCarville B, Merchant TE, Brennan R, Haik B, Rodriquez-Galindo C, Wilson MW. The effect of topotecan in advanced intraocular retinoblastoma with manageable toxicity. Cancer 118(22):5663-5670, 2012. PMCID: PMC3413782

Helton KJ, Triplett B. Severe fludarabine neurotoxicity in pediatric hematopoietic cell transplantation. Bone Marrow Transplant 48(5):729-731, 2013.

Zou P, Helton KJ, Li CS, Smeltzer M, Wang WC, Ware RE, Ogg R. BOLD and CBF responses during visual stimulation and cognitive function in children with sickle cell anemia. Brain Imaging Behav 5(4):295-306, 2011. PMCID: PMC3620037

Barb SM, Rodriguez-Galindo C, Wilson MW, Phillips NS,  Zou P, Scoggins MA, Helton KJ, Bikhazi G, Haik BG, Ogg RJ. Functional neuroimaging to characterize visual system development in children with retinoblastoma, investigative ophthalmology and visual science. Invest Ophthalmol Vis Sci 52(5):2619-2626, 2011. PMCID: PMC3088553

Saab R, Rodriguez-Galindo C, Matmati K, Rehg JE, Khoury JD, Billups C, Neale G, Helton KJ, Skapek S. p18Ink4c and p53 act as tumor suppressors in Cyclin D1–driven primitive neuroectodermal tumor.  Cancer Res 69(2):440-448, 2009. PMCID: PMC2629408

Helton KJ, Paydar A, Glass J, Weirich EM, Hankins J, Hankins G, Zou P, Li  CS, Smeltzer M, Wang WC, Ware RE, Reddick WE , Ogg RJ. Arterial spin-labeled perfusion combined with segmentation techniques to evaluate cerebral blood flow in white and gray matter of children with sickle cell anemia. Pediatr Blood Cancer 52(1):85-91, 2009. PMCID: PMC4480678

Wang W, Pavlakis S, Helton KJ, McKinstry R, Casella J, Adams R, Rees R. MRI abnormalities in the brain in one year-old children with sickle cell anemia. Pediatr Blood Cancer 51(5):643-646, 2008. PMID: 18478575

Helton KJ, Weeks J, Phillips N, Zou P, Li, C-S, Kun L, Fouladi M, Khan R, Boop FA, Gajjar A, Ogg R.  Diffusion tensor imaging of brainstem tumors: axonal degeneration of motor and sensory tracts. J Neurosurg Pediatr 1(4):270-276, 2008.

Fouladi M, Nicholson S, Zhou T, Laningham F, Helton KJ, Holmes E, Cohen K, Speights RA, Wright J, Pollack I.  A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high grade glioma, medulloblastoma/PNET or brainstem glioma: A Children’s Oncology Group Study. Cancer 110(11):2535-2541, 2007. PMID: 17932894

Helton KJ, Phillips N, Khan RB, Boop FA, Zou P, Langston J, Ogg R. Diffusion tensor imaging analysis of tract involvement of diffuse brainstem gliomas in children, with neurological correlation. Am J Neuroradiol 27(4):786-793, 2006. 

Woodard P, Helton KJ, Hale GA, Kasow KA, Leung W, Phipps S, Steen RG, Wang W, Handgretinger R, Cunningham JM. Central nervous system outcomes after hematopoietic stem cell transplantation for severe sickle cell disease. Br J Haematol 129(4):550-552, 2005.

Helton KJ, Edwards M, Steen RG, Merchant TE, Sapp MV, Boop FA, Langston J. Neuroimaging-detected late transient treatment-induced lesions in pediatric patients with brain tumors. J Neurosurg 102(2 Suppl):179-186, 2005. PMID: 16156228

Last update: June 2017