Kathleen J. Helton, MD
Kathleen J. Helton, MD

Kathleen J. Helton, MD

Member, St. Jude Faculty



MS – University of Tennessee School of Nursing, Memphis
MD – University of Tennessee School of Medicine, Memphis

Research Interests

  • Vasculopathy, DTI of white matter, ASL perfusion, structural/functional connectomes and fMRI in children with sickle cell anemia
  • The effect of tumor formation and chemotherapy on the structural and functional development of the visual system in children with retinoblastoma

Selected Publications

Brennan RC, Wilson MW, Kaste S, Helton KJ, McCarville MB. US and MRI of Pediatric Ocular Masses with Histopathological Correlation. Pediatr Radiol Jun;42(6):738-49, 2012. doi: 10.1007/s00247-012-2374-6. Epub 2012 Mar 31.

Helton KJ, Triplett B. Severe Fludarabine Neurotoxicity in Pediatric Hematopoietic Cell Transplantation. Bone Marrow Transplantation Oct 22, 2012. doi: 10.1038/bmt.2012.196. [Epub ahead of print].

Cejda KR, Brindas,Hansbury EN, Kimble AC, Mortier NA, Aygun B, Hankins JS, Helton KJ, McCarville ME, Smeltzer MP. The Use of Preparation and Support Procedures for Children with Sickle Cell Disease Undergoing MRI Testing. Pediatric Radiology Oct;42(10):1223-8, 2012.

Perko R, Harreld JH, Helton KJ, Sabin ND, Haidar CE, Wright KD. What Goes Around Comes Around? Wernicke Encephalopathy and the Nationwide Shortage of Intravenous Multivitamins Revisited. J Clin Oncol Nov 1;30(31), 2012.

Qaddoumi I, Billups C, Stewart CF, Wu J, Helton KJ, McCarville B, Merchant TE, Brennan R, Haik B, Rodriquez-Galindo C, Wilson MW. The Effect of Topotecan in Advanced Intraocular Retinoblastoma with Manageable Toxicity. Cancer Nov 15;118(22):5663-70, 2012. doi: 10.1002/cncr.27563. Epub 2012 Apr 19.).

DeWire M, Beltran C, Boop FA, Helton KJ, Ellison DW, McKinnon P, Gajjar A, Pai-Panandiker A, Radiation therapy and adjuvant chemotherapy in a patient with a malignant glioneuronal tumor and underlying ataxia telangiectasia: a case report and review of the literature. J Clin Oncol Jun 11, 2012. [Epub ahead of print].

Pai Panadiker AS, Merchant TE, Beltran C, Wu S, Sharma S, Boop FA, Jenkins JJ, Helton KJ, Wright KD, Broniscer A, Kun LE, Gajjar. Sequencing of Local Therapy Affects the Pattern of Treatment Failure and Survival in Children with Atypical Teratoid Rhabdoid Tumors of the Central Nervous System. Int J Radiat Oncol Biol Phys Apr 1;82(5):1756-63, 2012.

McCarville B; Brennan R, Kaste S, Gaither S, Helton KJ, Wilson MW. Exploring the Differential Diagnosis of Leukocoria: Ultrasound and MRI with Histopathologic Correlation. Ped Rad Epub 2012 Mar 31.

Zou P, Helton KJ, Li CS, Smeltzer M, Wang WC, Ware RE, Ogg R. BOLD and CBF Responses During Visual Stimulation and Cognitive Function in Children with Sickle Cell Anemia. Brain Imaging and Behavior Dec;5(4):295-306, 2011.

Brennan RC, Helton KJ, Pei D, Cheng C, Inaba H, Metzger ML, Howard SC, Rubnitz JE, Ribeiro RC, Sandlund JT, Jeha S, Pui CH, Bhojwani D. Spinal Epidural Lipomatosis in Children with Hematologic Malignancies. Ann Hematol Sep; 90(9):1067-74, 2011.

Barb SM, Rodriguez-Galindo C, Wilson MW, Phillips NS, Zou P, Scoggins MA, Helton KJ, Bikhazi G, Haik BG, Ogg RJ. Functional Neuroimaging to Characterize Visual System Development in Children with Retinoblastoma, Investigative Ophthalmology and Visual Science. Invest Ophthalmol Vis Sci Apr 20;52 (5):2619-26, 2011.

Saab R, Rodriguez-Galindo C, Matmati K, Rehg JE, Khoury JD, Billups C, Neale G, Helton KJ, Skapek S. p53-dependent senescence in Cyclin D1-driven pinealoma: recapitulating RB loss in children. Cancer Research Jan 15;69 (2):440-8, 2009.

Helton KJ, Paydar A, Glass J, WeirichEM, Hankins J, Hankins G, Zou P, Li CS, Smeltzer M , Wang WC, Ware RE, Reddick WE , Ogg RJ. Arterial Spin-Labeled Perfusion Combined with Segmentation Techniques to Evaluate Cerebral Blood Flow in White and Gray Matter of Children with Sickle Cell Anemia, Pediatric Blood and Cancer. Pediatr Blood Cancer Jan;52 (1):85-91, 2009.

Wang W, Pavlakis S, Helton KJ, McKinstry R, Casella J, Adams R, Rees R. MRI Abnormalities in the Brain in One Year-Old Children with Sickle Cell Anemia. Pediatric Blood and Cancer Nov 51(5) 643-646, 2008.

Helton KJ, Weeks J, Phillips N, Zou P, Li, C-S, Kun L, Fouladi M, Khan R, Boop FA, Gajjar A, Ogg R. Diffusion Tensor Imaging and Tractography in Pediatric Brain Stem Glioma Patients: Wallerian Degeneration of Corticospinal and Sensory Pathways. J Neurosurg Peds Apr;1(4):270-6, 2008.

Hankins JS, Helton KJ, McCarville MB, Li CS, Wang WC, Ware RE. Preservation of Spleen and Brain Function in Children with Sickle Cell Anemia Treated with Hydroxyurea. Pediatric Blood and Cancer Feb;50 (2):293-7, 2008.

Fouladi M, Nicholson S, Zhou T, Laningham F, Helton KJ, Holmes E, Cohen K, Speights RA, Wright J, Pollack I. A Phase II Study of the Farnesyl Transferase Inhibitor, Tipifarnib, in Children with Recurrent or Progressive High Grade Glioma, Medulloblastoma/PNET or Brainstem Glioma: A Children’s Oncology Group Study. Cancer Dec 1;110(11):2535-41, 2007.

Glass JO, Reddick WE, Li CS, Laningham FH, Helton KJ, Pui CH. Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate. Magn Reson Imag 24:785-791, 2006.

Fuller C, Fouldi M, Gajjar A, Dalton J, Sanford RA, Helton KJ. Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettes. Am J Clin Pathol 126:277-283, 2006.

Weeks J, Helton KJ, Conley ME, Khan RB. Diffuse CNS vasculopathy in X-linked lymphoproliferative disease. Am J Neuroradiol 27:884-886, 2006.

Fuller C, Helton K, Dalton J, Fouladi M, Kun L, Burger P. Polar spongioblastoma of the spinal cord: Case report. Pediatr Dev Pathol 9:75-80, 2006.

Helton KJ, Phillips N, Khan RB, Boop FA, Zou P, Langston J, Ogg R. Diffusion tensor imaging analysis of tract involvement of diffuse brainstem gliomas in children, with neurological correlation.Am J Neuroradiol 27:786-793, 2006.

Phillips NS, Sanford RA, Helton KJ, Boop FA, Gajjar A, Tekavtz T, Ogg RJ. Diffusion tensor imaging of intra-axial tumors at the cervicomedullary and pontomedullary junction. J Neurosurg 6(Suppl 103):557-562, 2005.

Reddick WE, Glass JO, Helton KJ, Xiong X, Wu S, Pui CH. A quantitative MRI assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation. Am J Neuroradiol 26(9):2371-2377, 2005.

Woodard P, Helton KJ, Hale GA, Kasow KA, Leung W, Phipps S, Steen RG, Wang W, Handgretinger R, Cunningham JM. Central nervous system outcomes after hematopoietic stem cell transplantation for severe sickle cell disease. Br J Hematol 129(4):550-552, 2005.

Reddick WE , Glass JO, Helton KJ, Langston JW, Xiong X, Wu S, Pui C-H. Leukoencephalopathy prevalence in children treated for acute lymphoblastic leukemia with high-dose methotrexate. Am J Neuroradiol 26:1263-1269, 2005.

Helton KJ, Edwards M, Steen RG, Merchant TE, Sapp MV, Boop FA, Langston J. Late transient MRI findings associated with treatment in pediatric brain tumor patients. J Neurosurg 102:179-186, 2005.

Last update: November 2012