Kellie Haworth, MD, FAAP, MAJ, MC, USAR
Kellie Haworth, MD, FAAP, MAJ, MC, USAR

Kellie Haworth, MD, FAAP, MAJ, MC, USAR

Assistant Member, St. Jude Faculty

Departments

Divisions

Education

MD - The Chicago Medical School, North Chicago, Illinois
BS - Indiana Wesleyan University, Marion, Indiana

Research Interests

Novel therapeutic approaches that induce anti-tumoral immunologic responses (immunotherapies) against pediatric neurogenic tumors:

  • Active oncolytic viroimmunotherapy
  • Adoptive cellular immune therapies
  • CAR T cell therapy
  • Immunosuppressive tumor microenvironmental reprogramming

Selected Publications

Haworth KB, Arnold MA, Pierson CR, Choi K, Yeager ND, Ratner N, Roberts RD, Finlay JL, Cripe TP. Immune profiling of NF1-associated tumors reveals histologic subtype distinctions and heterogeneity: Implications for immunotherapy. Oncotarget May 30, 2017. doi:10.18632/oncotarget.18301.

Studebaker AW, Hutzen BJ, Pierson CR, Haworth KB, Cripe TP, Jackson EM, Leonard JR. Oncolytic Herpes Virus rRp450 shows efficacy in orthotopic xenograft group 3/4 medulloblastomas and atypical teratoid/ rhabdoid tumors. Mol Ther Oncolytics 6:22-30, 2017.

Cassady KA, Haworth KB, Jackson J, Markert JM, Cripe TP. To infection and beyond: The multi-pronged anti-cancer mechanisms of oncolytic viruses. Viruses 8(2), pii E43, 2016.

Haworth KB, Arnold MA, Pierson CR, Leddon JL, Kurmashev DK, Swain HM, Hutzen BJ, Roberts RD, Cripe TP. Characterization of MHC Class I and β-2-microglobulin expression in pediatric solid malignancies to guide selection of immune-based therapeutic trials. Pediatr Blood Cancer 63:618-626, 2016.

Cripe TP, Chen CY, Denton NL, Haworth KB, Hutzen B, Leddon JL, Streby KA, Wang PY, Markert JM, Waters AM, Gillespie GY, Beierle EA, Friedman GK. Pediatric cancer gone viral. Part I: Strategies for utilizing oncolytic herpes simplex virus-1 in children. Mol Ther Oncolytics 2, pii: 15015, 2015.

Friedman GK, Beierle EA, Gillespie GY, Markert JM, Waters AM, Chen CY, Denton NL, Haworth KB, Hutzen B, Leddon JL, Streby KA, Wang PY, Cripe TP. Pediatric cancer gone viral. Part II: Potential clinical application of oncolytic herpes simplex virus-1 in children. Mol Ther Oncolytics 2, pii: 15016, 2015.

Leddon JL, Chen C-Y, Currier MA, Wang P-Y, Jung FA, Denton NL, Cripe KM, Haworth KB, Arnold MA, Gross AC, Eubank TD, Goins WF, Glorioso JC, Cohen JB, Grandi P, Hildeman DA, Cripe TP. Oncolytic HSV virotherapy in murine sarcomas differentially triggers an antitumor T-cell response in the absence of virus permissivity. Mol Ther Oncolytics 1:14010, 2015.

Haworth KB, Leddon JL, Chen CY, Horwitz EM, Mackall CL, Cripe TP. Going back to class I: MHC and immunotherapies for childhood cancer. Pediatr Blood Cancer 62(4):571-576, 2015.

Kerlin BA, Haworth K, Smoyer WE. Venous thromboembolism in pediatric nephrotic syndrome. Pediatr Nephrol 29(6):989-997, 2014.

Reigard SA, Zahn TJ, Haworth KB, Hicks KA, Fierke CA, Gibbs RA. Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase. Biochemistry 44(33):11214-11223, 2005.

Last update: August 2017