Randy Hock, MD, PhD

Randy Hock, MD, PhD

  • Clinic Physician

Departments

Education

BA - Johns Hopkins University, Baltimore, Maryland
PhD - Johns Hopkins University School of Medicine, Baltimore, Maryland
MD - Johns Hopkins University School of Medicine, Baltimore, Maryland
MA - Carnegie Mellon University, Heinz School of Public Policy and Management
Internship/Residency - University of Washington and Children's Orthopedic Hospital and Medical Center, Seattle, Washington
Fellowship - University of Washington and Children's Orthopedic Hospital and Medical Center, Seattle, Washington

Clinical Interests

  • Pediatric oncology

Selected Publications

Song W-J, Sullivan MG, Hock RA, Legare RD, et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nature Genetics Vol. 23, October 1999.

Heuer JG, Tucker-McClung CL, Hock RA. Neuroblastoma cells expressing mature IL-18, but not pro IL-18 induce a strong and immediate antitumor immune response. J lmmunother 22(4):324-35. 1999.

Hunt CR, Sim JE, Sullivan SJ, Featherstone T, Golden W, Von Kapp-Herr C, Hock RA, Gomez RA, Parsian AJ, Spitz DR: Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress. Cancer Res 58(17):3986-92, 1998.

Hanenberg H, Hashino K, Konishi H, Hock RA, Kato I, Williams DA. Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells. Human Gene Therapy 8:2193-2206, 1997.

Heuer JG, Tucker-McClung CL, Hock RA. Retroviral Mediated Gene Transfer ofB7-l and MHC Class II Converts a Poorly Immunogenic Neuroblastoma into a Highly Immunogenic One. Human Gene Therapy 7:2059-2068, 1996.

Hock RA, Reynolds BD, Tucker-McClung CL, Heuer JG. Murine neuroblastoma vaccines produced by retroviral transfer of MHC class II genes. Cancer Gene Ther 3:314-320, 1996.

Hock RA, Reynolds BD, Tucker-McClung CL, Kwok WW. Human class II major histocompatibility complex gene transfer into murine neuroblastoma leads to loss of tumorigenicity, immunity against subsequent tumor challenge, and elimination of microscopic pre-established tumors. J Immunother 17:12-18. 1995.

Gomez A, Norling  LL, Wilfong N, Isakson P,  Lynch KR,  Hock  RA, Quesenberry  P.   Leukocytes Synthesize Angiotensinogen. Hypertension 21: 470-475, 1993.

Osborne WRA, Hock RA, Kaleko M, Miller AD. Long-Term Expression of Human Adenosine Deaminase in Mice after Transplantation of Bone Marrow Infected with Amphotropic Retroviral Vectors. Human Gene Therapy 1:31-41, 1990.

Hock RA, Miller AD, Osborne WRA. Expression of Human Adenosine Deaminase from Various Strong Promoters after Gene Transfer into Human Hematopoietic Cell Lines.  Blood 74:876-881, 1989.

Kwok WW, Schwarz D, Nepom BS, Hock RA, Thurtle PS, Nepom GT. HLA-DQ Molecules Form Heterodimers of Mixed Allotype.  J Immunol 141:3123- 3127, 1988.

Palmer TD, Hock RA, Osborne, WRA, Miller, AD. Efficient Retrovirus-Mediated Transfer and Expression of Human Adenosine Deaminase (ADA) in Diploid Skin Fibroblasts from ADA-Deficient Humans. Proc Nat Acad Sci USA 84:1055-1059, 1986.

Anson DS, Hock RA, Austen D, et al. Towards gene therapy for hemophilia B. Mol Biol Med 4:4-11, 1987.

Miller AD, Palmer TD, Hock RA. Transfer of genes into Human Somatic Cells Using Retrovirus Vectors. Cold Spring Harb Syrop Quant Biol 51:1013-1019, 1986.

Hock RA, Miller AD. Retrovirus-Mediated Transfer and Expression of Drug Resistance Genes in Human Haematopoietic Progenitor Cells. Nature 320:275- 277, 1986.

Hock RA, Hollenberg MD. Characterization of the Receptor for Epidermal Growth Factor-Urogastrone in Human Placenta Membranes. J Biol Chem 255:10731, 1980.

Hock RA, Nexo E, Hollenberg MD. Solubilization and Isolation of the Human Placenta Receptor for Epidermal Growth Factor-Urogastrone. J Biol Chem 255:10737, 1980.

Nexo E, Hock RA, Hollenberg MD. Lectin Agarose Immobilization, a New Method for Detecting Soluble Membrane Receptors:  Application to Studies with Epidermal Growth Factor-Urogastrone and Transcobalamin II. J Biol Chem 254:8740, 1979.

Hock RA, Nexo E, Hollenberg MD. Isolation of the Human Placenta Receptor for Epidermal Growth Factor­Urogastrone. Nature 277:403-405,1979.

Sahyoun N, Hock RA, Hollenberg MD. Insulin and Epidermal Growth Factor-Urogastrone:  Affinity Cross­linking to Specific Binding Sites in Rat Liver Membranes. Proc Nat Acad Sci USA 75:1675-1679, 1978.

Tyson JE, Hock RA. Gestational and Pregestational Diabetes: An Approach to Therapy. Am J Ob Gyn 125:1009-1027, 1976.

Last update: May 2018