Guolian Kang, PhD
Guolian Kang, PhD

Guolian Kang, PhD

Assistant Member, St. Jude Faculty



PhD – Institute of Systems Science, Chinese Academy of Sciences, China
MS – Qufu Normal University, China
BS – Qufu Normal University, China

Research Interests

  • Statistical Genetics/Genomics
  • Systems Biology/Genetical Genomics
  • Bioinformatics/Modeling for Complex Data

Selected Publications

Yan S, Yuan S, Xu Z, Zhang B, Kang G, Byrnes A, Li Y. Likelihood based complex trait association testing for arbitrary depth sequencing data. Bioinformatics 2015, in press.

Bi W, Kang G, Zhao Y, Cui Y, Yan S, Li Y, Cheng C, Pounds SB, Borowitz MJ, Relling MV, Yang JJ, Liu Z, Pui CH, Hunger SP, Hartford C, Leung W, Zhang JF. SVSI: fast and powerful set-valued system identification approach to identifying rare variants in sequencing studies for ordered categorical traits. Annals of Human Genetics 2015, in press.

Bari R, Hartford C, Chan WK, Leung WH, Vong Q, Wendt W, Zhou Y, Cheng C, Kang G, Pui CH, Downing JR, Shurtleff S, Leung W. Genome-wide single-nucleotide polymorphism analysis revealed SUFU as a suppressor of acute graft-versus-host disease through downregulation of HLA-DR expression in recipient dendritic cells. Scientific Reports 2015, in press.

Cancio M, Helton KM, Schreiber J, Smeltzer MP, Kang G, Wang WC. Silent ischemic brain lesions in very young children with sickle cell anemia are associated with a higher risk of stroke. British Journal of Haematology 2015, in press.

Triplett BM, Shook DR, Eldridge P, Li Y, Kang G, Dallas M, Hartford C, Srinivasan A, Chan WK, Suwannasaen D, Inaba H, Pui CH, Leung W. Rapid Memory T-cell Reconstitution Recapitulating CD45RA-depleted Haploidentical Transplant Graft Content in Patients with Hematologic Malignancies. Bone Marrow Transplantation 2015, in press.

Wilson CL, Liu W, Yang JJ, Kang G, Ojha RP, Neale G, Srivastava DK, Gurney JG, Hudson MM, Robison LL, Ness KK. Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: a report from the St. Jude Lifetime cohort. Cancer 2015, in press.

Shook D, Triplett BM, Eldridge PW, Kang G, Srinivasan A, Leung W. Haploidentical stem cell transplantation augmented by CD45RA negative lymphocytes provides rapid engraftment and excellent tolerability. Pediatric Blood & Cancer 62(4): 666-673, 2015.

Addersson AK, Ma J, Wang J, Chen X, Larson-Gedman A, Dang J, Nakitandwe J, Holmfeldt L, Parker M, Eston J, Huether R, Kriwacki R,  Rusch M, Wu G, Li Y, Mulder H, Raimondi S, Pounds S, Kang G, Shi L, Becksfort J, Gupta P, Payne-Turner D, Vadodaria B, Boggs K, Yergeau D, Manne J, Song G, Edmonson M, Nagawatte P, Wei L, Cheng C, Pei D, Sutton R, Venn NC, Chetcuti A, Rush A, Catchpoole D, Heldrup J, Fioretos T, Lu C, Ding L, Pui CH, Shurtleff S, Gruber TA, Mullighan CG, Mardis ER, Wilson RK, Zhang J, Downing JR. The landscape of somatic mutations in infant MLL rearranged acute lymphoblastic leukemias. Nature Genetics 47(4): 330-337, 2015.

Srinivasan A, Srinivasan S, Sunthankar S, Sunkara A, Kang G, Stokes DC, Leung W. Pre-hematopoietic stem cell transplant lung function and pulmonary complications in children. Annals of the American Thoracic Society 11(10): 1576-1585, 2014.

Sullivan E, Jeha S, Kang G, Cheng C, Rooney B, Holladay M, Bari R, Schell S, Tuggle M, Pui CH, Leung W. NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate to post-induction residual disease. Clinical Cancer Research 20(23): 5986-5994, 2014.

Srinivasan A, Wang WC, Gaur A, Smith T, Gu Z, Kang G, Leung W, Hayden R. Prospective detection of respiratory pathogens in children with sickle cell disease and acute respiratory illness. Pediatric Blood and Cancer 61(3):507-511, 2014.

Srinivasan A, Panetta JC, Cross S, Pillai A, Triplett BM, Shook DR, Dallas MH, Hartford C, Sunkara A, Kang G, Jacobsen J, Choi J, and Leung W. Phase I study of the safety and pharmacokinetics of plerixafor in children undergoing a second allogeneic hematopoietic stem cell transplantation for relapsed or refractory leukemia. Biology Blood and Marrow Transplantation 20(8):1224-1228, 2014.

Kang G*, Bi W*, Zhao Y, Zhang J, Yang JJ, Xu H, Reilling MV, Loh ML, Hunger SP, Pounds S, Cheng C. A new system identification approach to identify genetic variants in sequencing studies for a binary phenotype. Hum Hered 78:104-116, 2014. *Co-first author. This work will be featured in the Scientific Highlights section of the St. Jude Scientific Report 2015.

Kang G, Jiang B, Cui Y. Gene-based genomewide association analysis: a comparison study. Current Genomics 14(4):250-255, 2013.

Srinivasan A, Gu Z, Smith T, Morgenstern M, Sunkara A, Kang G, Srivastava GK, Gaur AH, Leung W, Hayden RT. Prospective detection of respiratory pathogens in symptomatic children with cancer. The Pediatric Infectious Disease Journal 32(3): e99-e104, 2013.

Bari R, Rujkijyanont P, Sullivan E, Kang G, Turner V, Gan K, Leung W. Effect of donor KIR2DL1 allelic polymorphism on the outcome of pediatric allogeneic hematopoietic stem cell transplantation. Journal of Clinical Oncology 31(30): 3782-3790, 2013. *Reported by ScienceDaily in September 2013

Benavente CA, McEvoy JD, Finkelstein D, Wei L, Kang G, Wang YD, Neale G, Ragsdale S, Valentine V, Bahrami A, Temirov J, Pounds S, Zhang J, Dyer MA. Cross-species genomic and epigenomic landscape of retinoblastoma. Oncotarget 4(6): 844-859, 2013.

Rujkijyanont P, Morris C, Kang G, Gan K, Hartford C, Triplett B, Dallas M, Srinivasan A, Shook D, Pillai A, Pui CH, Leung W. Risk-adapted donor lymphocyte infusion based on chimerism and donor source in pediatric leukemia. Blood Cancer Journal 3:e137, 2013.

Kang G, Lin D, Hakonarson H, Chen J. Two-stage extreme phenotype sequencing design for discovering and testing common and rare genetic variants: efficiency and power. Human Heredity 73:139-147, 2012.

Chen J*, Kang G*, VanderWeele T, Zhang C, Mukherjee B. Efficient designs of gene-environment interaction studies: implications of Hardy-Weinberg equilibrium and gene-environment independence. Statistics in Medicine 31(22):2516-2530, 2012.

Gao G*, Kang G*, Wang J, Qin H, Jiang B, Li Q, Chen W, Liu N, Allison DB. A generalized sequential Bonferroni procedure using smoothed weights for genome-wide association studies incorporating information on Hardy-Weinberg disequilibrium among cases. Human Heredity 73:1-13, 2012. *Co-first author.

Yeung EH, Zhang C, Chen J, Bowers K, Hu FB, Kang G, Qi L. Polymorphisms in the Neuropeptide Y gene and the risk of obesity: findings from two prospective cohorts. Journal of Clinical Endocrinology and Metabolism 96:E2055-2062, 2011.

Jiang B, Zhang X, Zuo Y, Kang G. A powerful truncated tail strength method for testing multiple hypotheses in a dataset. Journal of Theoretical Biology 277:67-73, 2011. *The Science Unbound Foundation Best Paper Award in General Statistics Research.

Kang G, Gao G, Shete S, Redden DT, Chang B-L, Rebbeck TR, Barnholtz-Sloan JS, Patterson N, Pajewski NM, Allison DB. Capitalizing on admixture in genome-wide association studies: A two-stage testing procedure and application to height in African-Americans. Frontiers in Genetics 2:11, 2011. doi: 10.3389/fgene.2011.00011

Zuo Y, Kang G. A mixed two-stage analysis for detecting interacting genes in genomewide association studies. Journal of Theoretical Biology 262:576-583, 2010.

Kang G, Ye K, Allison DB, Liu N, Gao G. Weighted multiple hypothesis testing procedures. Statistical Applications in Genetics and Molecular Biology 8(1):Article 23, 2009.

Kang G, Yue W, Zhang J, Cui Y, Zuo Y, Zhang D. An entropy-based approach for testing genetic epistasis underlying complex diseases. Journal of Theoretical Biology 250:362-374, 2008. *Awarded 2009 best paper in the area of statistical genetics from Science Unbound Foundation

Cui Y, Kang G, Sun K, Qian M, Romero R, Fu W. Gene-centric genome-wide association study via entropy. Genetics 179:637-650, 2008. *Research highlighted in Nature Review Genetics (2008, Vol. 9 No. 6).

Kang G, Yue W, Zhang J, Huebner M, Zhang H, Ruan Y, Lu T, Ling Y, Zuo Y, Zhang D. Two-stage designs to identify the effects of SNP combinations on complex diseases. Journal of Human Genetics 53:739-746, 2008.

Kang G, Li S, Zhang J. Entropy-based models for interpreting life systems in traditional Chinese medicine. Evidence-based Complementary and Alternative Medicine 5(3):273-279, 2008. *Reported by the international media of “International Adaptogens” (Venezuela). Included in the monograph of “Transg´enicos” (Cuba).

Kang G, Zuo Y. Entropy-based joint analysis for two-stage genomewide association studies. Journal of Human Genetics 52:747-756, 2007.

Yue W*, Kang G*, Zhang Y, Qu M, Tang F, Han Y, Ruan Y, Lu T, Zhang J, Zhang D. Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects. Neurosci Lett 416:96-100, 2007. *Co-first author.

Yue W, Kang G, Zhang H, Tang F, Qu M, Han Y, Yan J, Ruan Y, Lu Y, Zhang D. Association study between schizophrenia and NRG1,G72,RGS4 polymorphisms (In Chinese). Chin J of Behavioral Med Sci 16:418-820, 2007. 

Yue W, Liu Z, Kang G, Yan J, Tang F, Ruan Y, Zhang J, Zhang D. Association of G72/G30 polymorphisms with early-onset and male schizophrenia. NeuroReport 17(18):1899-1902, 2006.

Kang G, Meng F. Oscillation criteria for second-order quasi-linear neutral difference equations. Journal of Engineering Mathematics 23(1):923-926, 2006.

Kang G. Oscillation criteria for second-order half-linear neutral difference equations. Journal of Mathematical Research and Exposition 26(2):247-252, 2006.

Kang G. Oscillation criteria for second-order nonlinear difference equation with “summation small” coefficient. Bull Korean Math Society 42(2):245-256, 2005.

Kang G, Zhang H. Oscillation criteria of solutions of nonlinear difference equations of second order. Annals of Differential Equations 20(1):41-48, 2004.

Last update: June 2015