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Kevin R. Krull, PhD
Kevin R. Krull, PhD

Kevin R. Krull, PhD

Member, St. Jude Faculty

  • Chair, Psychology and Biobehavioral Sciences
  • Endowed Chair in Psychology

Departments

Education

MS – Florida State University, Tallahassee (1986)
PhD – Florida State University, Tallahassee (1991)

Research Interests

  • Neurocognitive outcomes of childhood cancer
  • Late effects of cancer therapy
  • Biologic and psychosocial moderators/mediators
  • Treatment of attention and executive function problems

Selected Publications

Williams AM, Salehabadi SM, Xing M, Phillips NS, Ehrhardt MJ, Howell R, Yasui Y, Oeffinger K, Gibson T, Chow EJ, Leisenring W, Srivastava D, Hudson MM, Robison LL, Armstrong GT, Krull KR. Modifiable risk factors for neurocognitive and psychosocial problems after Hodgkin lymphoma. Blood. 2021 Dec 33:blood.2021013167. Online ahead of print. PMID: 34861035. DOI: 10.1182/blood.2021013167. *Role: Senior author

Hardy KK, Hudson MM, Krull KR. Life-altering consequences of neurocognitive impairment in survivors of pediatric cancer. J Clin Oncol. 2021 Jun 1;39(16):1693-1695. PMID: 33886347. DOI: 10.1200/JCO.21.00211. *Role: Senior author

Williams AM, Cheung YT, Hyun G, Liu W, Ness KK, Ehrhardt MJ, Mulrooney DA, Bhakta N, Banerjee P, Brinkman T, Green DM, Chemaitilly W, Huang I, Srivastava D, Hudson MM, Robison LL, Krull KR. Childhood neurotoxicity and brain resilience to adverse events during adulthood. Ann Neurol. 2021 Mar;89(3):534-545. PMCID: PMC7897299. DOI: 10.1002/ana.25981. Role: * Senior and corresponding author

van der Plas E, Qiu W, Nieman BJ, Yasui Y, Liu Q, Dixon SB, Kadan-Lottick NS, Weldon CB, Weil BR, Jacola LM, Gibson TM, Leisenring W, Oeffinger K, Hudson MM, Robison LL, Armstrong GT, Krull KR. Sex-specific associations between chemotherapy, chronic conditions and neurocognitive impairment in Acute Lymphoblastic Leukemia survivors: A report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2021 May 4;113(5):588-596. PMCID: PMC8096369. DOI: 10.1093/jnci/djaa136. *Role: Senior author

Bass JK, Liu W, Banerjee P, Brinkman TM, Mulrooney DA, Gajjar A, Pappo AS, Merchant TE, Armstrong GT, Srivastava D, Robison LL, Hudson MM, Krull KR. Association of hearing impairment with neurocognition in survivors of childhood cancer. JAMA Oncol. 2020 Jul 30;6(9):1-9. PMCID: PMC7393588. DOI: 10.1001/jamaoncol.2020.2822. Role: *Senior author

Banerjee P, Rossi MG, Anghelescu DL, Liu W, Breazeale AM, Reddick WE, Glass JO, Phillips NS, Jacola LM, Sabin ND, Inaba H, Srivastava D, Robison LL, Pui CH, Hudson MM, Krull KR. Association between anesthesia exposure and neurocognitive and neuroimaging outcomes in long-term survivors of childhood Acute Lymphoblastic Leukemia. JAMA Oncol. 2019 Oct 1;5(10):1456-1463. PMCID: PMC6587141. DOI: 10.1001/jamaoncol.2019.1094. *Role: Senior and corresponding author

Fellah S, Cheung YT, Scoggins MA, Zou P, Sabin ND, Pui CH, Robison LL, Hudson MM, Ogg RJ, Krull KR. Brain activity associated with attention deficits following chemotherapy for childhood acute lymphoblastic leukemiaJ Natl Cancer Inst. 2019 Feb 1;111(2):201-209. PMCID: PMC6376909. DOI: 10.1093/jnci/djy089. Role: Senior and corresponding author

Krull KR, Hardy KK, Kahalley LS, Schuitema I, Kesler SR. Neurocognitive outcomes and interventions in long-term survivors of childhood cancer. J Clin Oncol. 2018 Jul 20;36(21):2181-2189. PMCID: PMC6553837. DOI: 10.1200/JCO.2017.76.4696. *Role: First and corresponding author

Cheung YT, Khan RB, Liu W, Brinkman TM, Edelmann MN, Reddick WE, Pei D, Panoskaltsis-Mortari A, Srivastava D, Cheng C, Robison LL, Hudson MM, Pui CH, Krull KR. Association of cerebrospinal fluid biomarkers of central nervous system injury with neurocognitive and brain imaging outcomes in children receiving chemotherapy for acute lymphoblastic leukemia. JAMA Oncol. 2018 Jul 12;4(7):e180089. PMCID: PMC5885182. DOI: 10.1001/jamaoncol.2018.0089. * Role: Senior and corresponding author

Cheung YT, Brinkman TM, Li C, Mzayek Y, Srivastava D, Ness KK, Patel SK, Howell RM, Oeffinger KC, Robison LL, Armstrong GT, Krull KR. Chronic health conditions and neurocognitive function in aging survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2018 Apr 1;110(4):411-419. PMCID: PMC6059140. DOI: 10.1093/jnci/djx224. *Role: Senior and corresponding author

Cheung YT, Sabin ND, Reddick WE, Bhojwani D, Liu W, Brinkman TM, Glass JO, Hwang SN, Srivastava D, Pui CH, Robison LL, Hudson MM, Krull KR. Leukoencephalopathy and long-term neurobehavioral, neurocognitive and brain imaging outcomes in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy: A longitudinal analysis. Lancet Haematol. 2016;3(10):e456-e466. PMCID: PMC5417340. DOI: 10.1016/S2352-3026(16)30110-7. *Role: Senior and corresponding author

Jacola LM, Edelstein K, Liu W, Pui CH, Hayashi R, Kadan-Lottick NS, Srivastava D, Henderson T, Leisenring W, Robison LL, Armstrong GT, Krull KR. Cognitive, behavior and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: A report from the Childhood Cancer Survivor Study. Lancet Psychiatry. 2016;3(10):965-972. PMCID: PMC5056029. DOI: 10.1016/S2215-0366(16)30283-8. *Role: Senior author

Brinkman TM, Li C, Vannatta K, Marchak JG, Lai JS, Prasad PK, Kimberg C, Vuotto S, Di C, Srivastava D, Robison LL, Armstrong GT, Krull KR. Behavioral, social and emotional symptom comorbidities and profiles in adolescent survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J Clin Oncol. 2016;34(28):3417-3425. PMCID: PMC5035122. DOI: 10.1200/JCO.2016.66.4789. Role: Senior author

Krull KR, Cheung YT, Liu W, Fellah S, Reddick WE, Brinkman TM, Kimberg C, Ogg R, Srivastava DK, Pui CH, Robison LL, Hudson MM. Chemotherapy pharmacodynamics, neuroimaging and neurocognitive outcomes in long-term survivors of childhood acute lymphoblastic leukemia.  J Clin Oncol. 2016;34(22):2644-2653. PMCID: PMC5321052. DOI: 10.1200/JCO.2015.65.4574. *Role: First and corresponding author

Brinkman TM, Krasin MJ, Liu W, Armstrong GT, Ojha RP, Sadighi ZS, Gupta P, Kimberg C, Srivastava D, Merchant TE, Gajjar A, Robison LL, Hudson MM, Krull KR. Long-term neurocognitive functioning and social attainment in adult survivors of pediatric CNS tumors: Results from the St. Jude Lifetime Cohort Study. J Clin Oncol. 2016 Apr 20;34(12):1358-1367. PMCID: PMC4933131. DOI: 10.1200/JCO.2015.62.2589. *Role: Senior author

Edelmann MN, Daryani VM, Bishop MW, Liu W, Brinkman TM, Stewart CF, Mulrooney DA, Kimberg C, Ness KK, Cheung YT, Srivastava DK, Robison LL, Hudson MM, Krull KR.  Neurocognitive and patient-reported outcomes in adult survivors of childhood osteosarcoma. JAMA Oncol. 2016;2(2):201-208. PMCID: PMC4752424. DOI: 10.1001/jamaoncol.2015.4398. Role: Senior and corresponding author

Fullerton HJ, Stratton K, Mueller S, Leisenring WW, Armstrong GT, Weathers RE, Stovall M, Sklar CA, Goldsby RE, Robison LL, Krull KR. Recurrent stroke in childhood cancer survivors. Neurology. 2015;85(12):1056-1064. PMCID: PMC4603599. DOI: 10.1212/WNL.0000000000001951. *Role: Senior author

Prasad PK, Hardy KK, Zhang N, Edelstein K, Srivastava DK, Zeltzer L, Stovall M, Seibel NL, Leisenring W, Armstrong GT, Robison LL, Krull K. Psychosocial and neurocognitive outcomes in adult survivors of adolescent and early young adult cancer: A report from the Childhood Cancer Survivor Study. J Clin Oncol. 2015;33(23):2545-2552. PMCID: PMC4525049. DOI: 10.1200/JCO.2014.57.7528. *Role: Sole author

Huang IC, Brinkman TM, Kenzik K, Gurney JG, Ness KK, Lanctot J, Shenkman E, Robison LL, Hudson MM, Krull KR. Association between the prevalence of symptoms and health-related quality of life in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort study. J Clin Oncol. 2013; 31(33):4242-4251. PMCID: PMC3821013. DOI: 10.1200/JCO.2012.47.8867. *Role: Senior author

Krull KR, Brinkman TM, Li C, Armstrong GT, Ness KK, Gurney JG, Kimberg C, Srivastava DK, Krasin MJ, Pui CH, Robison LL, Hudson MM. Neurocognitive outcomes decades after treatment for childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort study. J Clin Oncol. 2013; 31(35):4407-4415. PMCID: PMC3842908. DOI: 10.1200/JCO.2012.48.2315. *Role: First and corresponding author

Krull KR, Zhang N, Srivastava DK, Santucci A, Krasin MJ, Kun LE, Pui CH, Hudson MM, Robison LL, Armstrong GT. Long-term decline in intelligence among adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation. Blood. 2013; 122(4):550-553. PMCID: PMC3724191. DOI: 10.1182/blood-2013-03-487744. *Role: First and corresponding author

Armstrong GT, Reddick WE, Petersen RC, Santucci A, Zhang N, Srivastava DK, Ogg RJ, Hillenbrand CM, Sabin N, Krasin MJ, Kun L, Pui CH, Hudson MM, Robison LL, Krull KR. Evaluation of memory impairment in aging adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiotherapy. J Natl Cancer Inst. 2013; 105(12):899-907. PMCID: PMC3687368. DOI: 10.1093/jnci/djt089. *Role: Senior author

Krull KR, Bhojwani D, Conklin H, Pei D, Cheng C, Reddick WE, Sandlund J, Pui CH. Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia. J Clin Oncol. 2013; 31(17):2182-2188. PMCID: PMC3731978. DOI: 10.1200/JCO.2012.46.7944. . *Role: First and corresponding author

Krull KR, Sabin ND, Reddick WE, Zhu L, Armstrong GT, Green DM, Arevalo A, Krasin MJ, Srivastava DK, Robison LL, Hudson MM. Neurocognitive function and CNS integrity in adult survivors of childhood Hodgkin lymphoma. J Clin Oncol. 2012; 30(29):3618-3624. PMCID: PMC3462045. DOI: 10.1200/JCO.2012.42.6841. *Role: First author

Kinahan KE, Sharp LK, Seidel K, Leisenring W, Didwania A, Lacouture ME, Stovall M, Haryani A, Robison LL, Krull KR. Scarring, disfigurement, and quality of life in long-term survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J Clin Oncol. 2012; 30(20):2466-2474. PMCID: PMC3397782. DOI: 10.1200/JCO.2011.39.3611. *Role: Senior author

Clanton NR, Klosky JL, Li C, Jain N, Srivastava DK, Mulrooney D, Zeltzer L, Stovall M, Robison LL, Krull KR. Fatigue, vitality, sleep and neurocognitive functioning in adult survivors of childhood cancer: A Report from the Childhood Cancer Survivor Study. Cancer. 2011; 117(11):2559-2568. PMCID: PMC3135668. DOI: 10.1002/cncr.25797. *Role: Senior and corresponding author

Kadan-Lottick NS, Zeltzer LK, Liu Q, Yasui Y, Ellenberg L, Gioia G, Robison LL, Krull KR. Neurocognitive functioning in adult survivors of non-central nervous system cancers: A report from the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2010; 102(12):881-893. PMCID: PMC2886093. DOI: 10.1093/jnci/djq156. *Role: Senior author

Zeltzer LK, Recklitis C, Buchbinder D, Zebrack B, Casillas J, Tsao JCI, Lu Q, Krull KR. Psychological status in childhood cancer survivors: A report from the Childhood Cancer Survivor Study. J Clin Oncol. 2009; 27(14):2396-2404. PMCID: PMC2677925. DOI: 10.1200/JCO.2008.21.1433. *Role: Senior author

Pui CH, Krull KR, Relling M. Treating childhood leukemia without cranial irradiation: The authors and a colleague reply. N Engl J Med. 2009; 361(13):1311-1312. PMID: 19776415. DOI: 10.1056/NEJMc091522

Krull KR, Okcu MF, Potter B, Jain N, Dreyer Z, Kamdar K. Brouwers P. Screening for neurocognitive impairment in pediatric cancer long-term survivors. J Clin Oncol. 2008; 26(25):4138-4143.  PMID: 18757327. DOI: 10.1200/JCO.2008.16.8864. *Role: First author

Last update: February 2022

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