Wing H. Leung, MD, PhD
Wing H. Leung, MD, PhD

Wing H. Leung, MD, PhD

Member, St. Jude Faculty



MD – University of Hong Kong
PhD – Johns Hopkins University

Research Interests

  • NK cell and stem cell transplantation
  • Late effect and molecular epidemiology

Selected Publications

Leung WH, Vong QP, Lin W, Janke L, Chen T, Leung W. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation. J Exp Med 210(12):2675-2692, 2013.

Bari R, Rujkijyanont P, Sullivan E, Kang G, Turner V, Gan K, Leung W. Effect of donor KIR2DL1 allelic polymorphism on the outcome of pediatric allogeneic hematopoietic stem-cell transplantation. J Clin Oncol 31(30):3782-90, 2013.

Chan WK, Rujkijyanont P, Neale G, Yang J, Bari R, Das Gupta N, Holladay M, Rooney B, Leung W. Multiplex and genome-wide analyses reveal distinctive properties of KIR+ and CD56+ T cells in human blood. J Immunol 191(4):1625-36, 2013.

Rujkijyanont P, Chan WK, Eldridge PW, Lockey T, Holladay M, Rooney B, Davidoff AM, Leung W. Ex Vivo activation of CD56+ immune cells that eradicate neuroblastoma. Cancer Res 73(8): 2608-18, 2013.

Chan WK, Kung Sutherland M, Li Y, Zalevsky J, Schell S, Leung W. Antibody-dependent cell-mediated cytotoxicity overcomes NK cell resistance in MLL-rearranged leukemia expressing inhibitory KIR ligands but not activating ligands. Clin Cancer Res 18(22):6296-305, 2012.

Leung W, Pui CH, Coustan-Smith E, Yang J, Pei D, Gan K, Rubnitz JE, Sandlund JT, Ribeiro RC, Srinivasan A, Hartford C, Triplett BM, Dallas M, Pillai A, Handgretinger R, Laver JH, Campana D, Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia. Blood 120(2):468-472, 2012.

Inaba H, Yang J, Kaste SC, Hartford CM, Motosue MS, Chemaitilly W, Triplett BM, Shook DR, Pui CH,Leung W. Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation. J Clin Oncol 30(32):3991-7, 2012.

Leung W, Campana D, Yang J, Pei D, Coustan-Smith E, Gan K, Rubnitz JE, Sandlund JT, Ribeiro RC, Srinivasan A, Hartford C, Triplett BM, Dallas M, Pillai A, Handgretinger R, Laver JH, Pui CH. High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia. Blood 118(2):223-30, 2011.

Rubnitz JE, Inaba H, Ribeiro RC, Pounds S, Rooney B, Bell T, Pui CH, Leung W. NKAML: A pilot study of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J Clin Oncol 28(6):955-9, 2010.

Bari R, Bell T, Leung WH, Vong QP, Chan WK, Dasgupta N, Holladay M, Rooney B, Leung W. Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine245. Blood114(25):5182-90, 2009.

Leung W, Ahn H, Rose SR, Phipps S, Smith T, Gan K, O'connor M, Hale GA, Kasow KA, Barfield RC, Madden RM, Pui CH. A Prospective Cohort Study of Late Sequelae of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation. Medicine 86(4):215-224, 2007.

Triplett B, Handgretinger R, Pui CH, Leung W. KIR-incompatible hematopoietic-cell transplantation for poor prognosis infant acute lymphoblastic leukemia. Blood 107(3):1238-9, 2006.

Leung W, Iyengar R, Triplett B, Turner V, Behm FG, Holladay MS, Houston J, Handgretinger R. Comparison of killer Ig-Like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors. J Immunol 174(10):6540-6545, 2005.

Leung W, Iyengar R, Turner V, Lang P, Bader P, Conn P, Niethammer D, Handgretinger R. Determinants of antileukemia effects of allogeneic NK cells. J Immunol 172(1):644-650, 2004.

Leung W, Rose SR, Zhou Y, Hancock ML, Burstein S, Schriock EA, Lustig R, Danish RK, Evans WE, Hudson MM, Pui CH. Outcomes of growth hormone replacement therapy in survivors of childhood acute lymphoblastic leukemia. J Clin Oncol 20(13):2959-2964, 2002.

Leung W, Hudson MM, Strickland DK, Phipps S, Srivastava DK, Ribeiro RC, Rubnitz JE, Sandlund JT, Kun LE, Bowman LC, Razzouk BI, Mathew P, Shearer P, Evans WE, Pui CH. Late effects of treatment in survivors of childhood acute myeloid leukemia. J Clin Oncol 18:3273-3279, 2000.

Last update: November 2013