Malia B. Potts, PhD
Malia B. Potts, PhD

Malia B. Potts, PhD

Assistant Member, St. Jude Faculty

Departments

Education

PhD – University of Texas Southwestern Medical Center, Dallas, Texas
BS
– Duke University, Durham, North Carolina

Research Interests

  • Higher-order regulation of autophagy
  • Metabolic balance between anabolic cell growth and catabolic self-renewal
  • Functional annotation of human genes and anti-cancer compounds

Selected Publications

Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, Purinton S, Wang Y, Ivan C, Kim HS, Borkowski RJ, Khan S, Rodriguez-Aguayo C, Lopez-Berestein G, Lea J, Gazdar A, Baggerly KA, Sood AK, White MA. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Mol Syst Biol 11(12):842, 2015.

Potts MB, McMillan EA, Rosales TI, Kim HS, Ou Y-H, Toombs JE, Brekken RA, Minden MD, MacMillan JB, White MA. Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B. Nat Chem Biol 11(6):401-8, 2015.

Pineda CT, Ramanathan S, Fon Tacer K, Weon JL, Potts MB, Ou YH, White MA, Potts PR.  Degradation of AMPK by a cancer-specific ubiquitin ligase. Cell 160(4):715-28, 2015.

Potts MB, Kim HS, Fisher KW, Hu Y, Carrasco Y, Bulut GB, Ou Y-H, Herrera-Herrera ML, Cubillos F, Mendiratta S, Xiao G, Hofree M, Ideker T, Xie Y, Huang L J-S, Lewis RE, MacMillan JB, White MA. Using Functional Signature Ontology (FUSION) to identify mechanisms of action for natural products. Sci Signal 6(297):ra90, 2013.

*Hu Y, *Potts MB, Colosimo D, Herrera-Herrera ML, Legako AG, Yousufuddin M, White MA, MacMillan JB. Discoipyrroles A-D: Isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis. J Am Chem Soc 135(36):13387-92, 2013. *Equal contribution.

Potts MB, Cameron S. Cell lineage and cell death: Caenorhabditis elegans and cancer research. Nat Rev Cancer 11(1):50-8, 2011.

Potts MB, Wang DP, Cameron S. Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1. Dev Biol 329(2):374-85, 2009.

Liu H, Strauss TJ, Potts MB, Cameron S. Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1. Development 133(4):641-50, 2006.

Potts MB, Vaughn AE, McDonough H, Patterson C, Deshmukh M. Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP. J Cell Biol 171(6):925-30, 2005.

Deming PB, Schafer ZT, Tashker JS, Potts MB, Deshmukh M, Kornbluth S. BCR-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. Mol Cell Biol 23:10289-99, 2004.

Potts PR, Singh S, Knezek M, Thompson CB, Deshmukh M. Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J Cell Biol 163(4):789-799, 2003.

Last update: February 2016