Fatima Rivas, PhD
Fatima Rivas, PhD

Fatima Rivas, PhD

Assistant Member, St. Jude Faculty

Departments

Education

BS – California State University, Dominguez Hills, Carson, California
MS – University of California, San Diego, La Jolla, California
PhD – University of California, San Diego, La Jolla, California

Honors & Awards

  • 2012 Keystone Symposia Early Career Investigator Travel Award
  • 2011 Carl Storm Underrepresented Minority Fellowship
  • 2009-2010 Keystone Symposia on Molecular and Cellular Biology Fellowship
  • 2006-2010 IRACDA Postdoctoral Fellow, University of California San Diego, and San Diego State University
  • 2002-2006 The Institute on Teaching and Mentoring Southern Regional Education Board/NSF Alliances for Graduate Education and the Professoriate Scholar Program Fellowship
  • 2002-2006 Ruth L. Kischstein National Research Service Award Individual Pre-doctoral Fellowship

Research Interests

  • Target oriented chemical synthesis of novel natural products from terrestrial plants, guided by certain tropical folk medicine (such as the Erythrina alkaloids and the Trichothecenes).
  • Upon the development of flexible and efficient synthetic approaches, rational-designed libraries will be synthesized for biological screening, and facilitate the development of therapeutic agents for the treatment of cancer and metabolic syndrome-related disorders.
  • Isolation and structure elucidation of natural products of medicinal interest.

Selected Publications

Hamulić, D.; Stadler, M.; Hering, S.; Padrón, J. M.; Bassett, R., Rivas, F.; Dea-Ayuela, M. A.; González-Cardenete, M. A. First Synthesis and Biological studies of the Abietane (+)-liquiditerpenoic acid A (abietopinoic acid) and some analogues: SAR studies. J. Nat. Prod., 82 (4), 823-831, 2019.

Kearney, S. E.; Zahoránszky-Kőhalmi, G.; Brimacombe, K. R.; Henderson, M. J.; Lynch, C.; Zhao, T.; Wan, K. K.; Itkin, Z.; Dillon, C.; Shen, M. ; Cheff, D. M. ; Lee, T. D. ; Bougie, D.; Cheng, K. ; Coussens, N.; Dorjsuren, D.; Eastman, R.T.; Huang, R.; Iannotti, M.; Karavadhi, S.; Klumpp-Thomas, C.; Roth, J.; Sakamuru, S.; Sun, W.; Titus, S. A.; Yasgar, A.; Zhang, Y.-Q.; Zhao, J.; Andrade, R. B.; Brown, M. K.; Burns, N. Z.; Cha, J. K.;  Mevers, E. E.; Clardy, J.; Clement, J. A.; Crooks, P. A.; Cuny, G. D.; Ganor, J.; Moreno, J.; Morrill, L. A., Picazo, E.; Susick, R.B.; Garg, N. K.; Goess, B. C.; B. Grossman, R., Hughes, C.C.; Johnston, J. N.; Joullié, M.M.; Kinghorn, A. D.; Kingston, D.G.I.; Krische, M. J.; Kwon, O.; Maimone, T.J.; Majumdar, S.; Maloney, K. N.; Mohamed, E., Murphy, B.T.; Nagorny, P.; Olson, D.E., Overman, L.E.; Brown, L. E.;  Snyder, J. K.; A. Porco, Jr., J.; Rivas, F.; Ross, S. A.; Sarpong, R., Sharma, I.; Shaw, J.T.; Xu, Z.; Shen, B.; Shi, W.; Stephenson, C., Verano, A.L.; Tan, D.S.; Tang, Y.; Taylor, R. E.; Thomson, R.J.; Vosburg, D.A.; Wu, J., Wuest, W.M.; Zakarian, A.; Zhang, Y.; Ren, T.; Zuo, Z.; Inglese, J.; Michael, S.; Simeonov, A.; Zheng, W.; Shinn, P.; Jadhav, A.; Boxer, M.B.; Hall, M. D.; Xia, M.; Guha, R.; Rohde, J. M. Canvass: A Crowd-Sourced, Natural Product Screening Library for Exploring Biological Space. Chemrxiv.  https://doi.org/10.26434/chemrxiv.7172369.v1 .  ACS Cent. Sci., 4(12), 1727-1741, 2018.

Stoddard, S. V.; May, X.; Rivas, F.; Dodson, K.; Vijayan, S.; Adhika, S.; Parker; K.; Watkins, D., Design of Potent Panobinostat Histone Deacetylase Inhibitor Derivatives: Molecular Considerations for Enhanced Isozyme Selectivity between Histone Deacetylase 2 (HDAC2) and Histone Deacetylase 8 (HDAC8). Molecular Informatics. 37, 1800080, 2018. doi: 10.1002/minf.201800080. PMID:30369061. 

Fatima, I.; El-Ayachi, I.; Ling, T.; Lillo, M. A.; Krutilina, R.; Seagroves, T. N.; Radaszkiewicz, T. W.; Hutnan, M.; Bryja, V.; Krum, S. A.; Rivas, F.; Miranda-Carboni, G. A. The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer. PLoS One.  12(12): e0189864, 2017.

Ling, T.; Miller, D.J.; Lang, W.H.; Griffith, E.; Rodriguez-Cortes, A.; El Ayachi I, Palacios, G.; Min, J.; Miranda-Carboni G.; Lee, R.E.; Rivas, F*. Mechanistic insight on the mode of action of colletoic acid. J. Med. Chem. 2019 Jul 24. doi: 10.1021/acs.jmedchem.9b00187.  

Ling, T., Lang, W. H., Maier, J., Rivas, F*. Cytostatic and cytotoxic natural products against cancer cellular models. Molecules. 2019 May 26;24(10). pii: E2012. doi: 10.3390/molecules24102012.

Ling, T.; Lang, W. H.; Craig, J.; Potts, M. B.; Budhraja, A.; Opferman, J.; Bollinger, J.; Rivas, F*. Studies of Jatrogossone A from Jatropha gossypiifolia as a reactive oxygen species inducer in cancer cellular models. J Nat. Prod. 2019 May 14. doi: 10.1021/acs.jnatprod.8b01087. PMID: 31084028

Ling, T.; Lang, W. H.; Martinez-Montemayor, M*.; Rivas, F*. Development of ergosterol peroxide probes for cellular localization studies. Org. Biomol. Chem. 2019 Apr 26. doi: 10.1039/c9ob00145j. (Front cover, Ed. 17).

Ling, T.; Meir, J.; Das, S.; Budhraja, A.; Bassett, R.; Potts, M.; Shelat, A.; Rankovic, Z.; Opferman, J. T*.; Rivas, F*. Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents. Eur. J. Med. Chem. 164, 391-398. 2018. PMID:30611980

Martínez-Montemayor*, M. M.; Ling, T.; Suárez-Arroyo, I. J.; Ortiz Soto, G.; Negrón, C. S.; Lacourt-Ventura, M. Y.; Valentín-Acevedo, A.; Lang, W. H.; Rivas, F*. Identification of biologically active Ganoderma lucidum compounds and synthesis of novel and improved derivatives that confer anti-cancer activities tested in different in vitro cancer models. Front. Pharmacol. 10:115, 1-17, 2019.

Ling, T.; Lang, W.; Feng, X.; Das, S.; Maier, J.; Jeffries, C.; Shelat, A.; Rivas, F*.  Novel vitexin-inspired scaffold against leukemia. Eur. J. Med. Chem. 146, 501-510, 2018. PMID:29407975

Rivas, F*.; Ling, T. All- carbon quaternary centers in natural products and medicinal chemistry: recent advancements. Tetrahedron, 72, 6729-6777, 2016.

Rivas, F*.; Ling, T. Synthetic advances towards functionalized γ-lactams featuring (-)- salinosporamide A and related natural products. Org Prep and Proced Int. 3, 254-295, 2016.

Gautam, L. N.; Ling, T.; Lang, W.; Rivas, F*. Anti-proliferative evaluation of monoterpene derivatives against leukemia. Eur. J. Med. Chem., 113, 75-80, 2016.

O Ling, T.; Gautam, L. N.; Griffith, E.; Das, S.; Lang, W.; Shadrick, W. R.; Shelat, A.; Lee, R. E.; Rivas, F*. Synthesis and evaluation of colletoic acid core derivatives. Eur. J. Med. Chem. 110 126-132, 2016.

Last update: October 2019