Wilburn E. Reddick, PhD
Wilburn E. Reddick, PhD

Wilburn E. Reddick, PhD

Member, St. Jude Faculty

  • Director, Diagnostic Image and Signal Processing Laboratory

Departments

Divisions

Education

MS – Memphis State University, Memphis, Tennessee
PhD – Memphis State University, Memphis, Tennessee

Research Interests

Developing and validating quantitative methods used to assess structural brain injury:

  • Tissue segmentation and classification
  • Registration and spatial normalization algorithms for multimodality imaging
  • Diffusion tensor imaging
  • Myelin water imaging
  • Cortical thickness measures

Structure-function relationship of white matter injury as a result of pharmacological or radiological insult through quantitative MR measures:

  • White matter injury attributed to cranial irradiation or chemotherapy
  • Relationship of white matter injury and neurocognitive function
  • Relationship of white matter injury and neurocognitive response to intervention

Assessing solid tumor response to therapy:

  • Pharmacokinetic modeling of dynamic contrast-enhanced MR imaging to assess and predict solid tumor response

Selected Publications

Jacola LM, Krull K, Pui C-H, Pei D, Cheng C, Reddick WE, Conklin HC. Longitudinal assessment of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia treated on a contemporary chemotherapy protocol. J Clin Onc 2016 (in press).

Guo J, Glass JO, McCarville MB, Shulkin BL, Daryani VM, Stewart CF, Wu J, Mao S, Dwek JR, Fayad LM, Madewell JE, Navid F, Daw NC, Reddick WE. Assessing vascular effects of adding bevacizumab to neoadjuvant chemotherapy in osteosarcoma using DCE-MRI. Brit J Cancer 113(9):1282-8, 2015.

Jacola LM, Ashford JM, Reddick WE, Glass JO, Ogg RJ, Merchant TM, Conklin HM. The relationship between working memory and cerebral white matter volume in survivors of childhood brain tumors treated with conformal radiation therapy. J Neuro-Oncology 119(1):197-205, 2014.

Edelmann MN, Krull KR, Liu W, Glass JO, Ji Q, Ogg RJ, Sabin ND, Srivastava DK, Robison LL, Hudson MM, Reddick WE. Diffusion tensor imaging and neurocognition in survivors of childhood acute lymphoblastic leukemia. Brain 137(Pt 11):2973-83, 2014.

Reddick WE, Taghipour DJ, Glass JO, Ashford J, Xiong X, Wu S, Bonner M, Khan RB, Conklin HM. Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers. Pediatr Blood Cancer 61(6):1074-1079, 2014.

Bhojwani D, Sabin ND, Pei D, Yang JJ, Khan R, Panetta C, Krull KR, Inaba H, Rubnitz JE, Metzger ML, Howard SC, Ribeiro RC, Cheng C, Reddick WE, Jeha S, Sandlund JT, Evans WE, Pui CH, Relling MV. Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia. J Clin Onc 32(9):949-59, 2014.

Krull KR, Bhojwani D, Conklin HM, Pei D, Cheng C, Reddick WE, Sandlund JT, Relling MV, Pui C-H. Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia. J Clin Onc 31(17):2182-8, 2013.

Armstrong GT, Reddick WE, Petersen RC, Santucci A, Zhang N, Srivastava D, Ogg RJ, Hillenbrand CM, Sabin N, Krasin MJ, Kun L, Pui C-H, Hudson MM, Robison LL, Krull KR. Dementia in adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiotherapy. J Natl Cancer Inst 105(12):899-907, 2013

Guo J-Y, Qing J, Reddick WE. Multi-slice myelin water imaging for practical clinical applications at 3.0 T. Mag Reson Med 70:813-822, 2013.

Conklin HM, Krull KR, Reddick WE, Pei D, Cheng C, Pui C-H. Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia. J Natl Cancer Inst 104(18):1386-9, 2012.

Palmer SL, Glass JO, Li Y, Ogg RJ, Quddoumi I, Armstrong GT, Wright K, Wetmore C, Broniscer A, Gajjar A, Reddick WE. White matter integrity is associated with cognitive processing in patients treated for posterior fossa brain tumor. NeuroOncology 14(9):1185–93, 2012.

Guo J-Y, Reddick WE, Glass JO, Ji Q, Billups CA, Wu J, Hoffer FA, Kaste SC, Jenkins JJ, Flores XCO, Quintana J, Villarroel M, Daw NC. Dynamic contrast-enhanced magnetic resonance imaging as a prognostic factor in predicting event-free and overall survival for pediatric patients with osteosarcoma. Cancer 118(15):3776-85, 2012.

Reddick WE, Conklin HM. Impact of acute lymphoblastic leukemia therapy on attention and working memory in children. Expert Rev Hematol 3(6):655-659, 2010.

Ashford J, Schoffstall C, Reddick WE, Leone C, Laningham F, Glass JO, Pei D, Pui C-H, Conklin HM. Attention and working memory abilities in children treated for acute lymphoblastic leukemia. Cancer116(19):4638-4645, 2010.

Palmer SL, Reddick WE, Glass JO, Ogg RJ, Patay Z, Wallace D, Gajjar A. Regional white matter anisotropy and reading ability in children treated for embryonal tumors. Brain Imaging and Behavior 4(2):132-140, 2010.

Reddick WE, Glass JO, Johnson DP, Laningham FH, Pui C-H. Voxel based analysis of T2 hyperintensities in white matter during treatment for childhood leukemia. Am J Neuroradiol 30(10):1947-1954, 2009.

Reddick WE, Laningham FH, Glass JO, Pui C-H. Quantitative morphologic evaluation of magnetic resonance imaging during and after treatment of childhood leukemia. Neuroradiology 49(11):889-904, 2007.

Reddick WE, Shan ZY, Glass JO, Helton S, Xiong X, Wu S, Bonner MJ, Howard SC, Christensen R, Khan RB, Pui C-H, Mulhern RK. Smaller white matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia. Cancer 106(4):941-949, 2006.

Reddick WE, Glass JO, Palmer SL, Wu S, Gajjar A, Langston JW, Kun LE, Xiong X, Mulhern RK. Atypical white matter volume development in children following craniospinal irradiation. Neuro Onc 7(1):12-19, 2005.

Reddick WE, Glass JO, Helton KJ, Langston JW, Xiong X, Wu S, Pui C-H. Prevalance of leukoencephalopathy in children treated for acute lymphoblastic leukemia with high-dose methotrexate. Am J Neuroradiol 26(5):1263-1269, 2005.

Reddick WE, Glass JO, Helton KJ, Langston JW, Li C-S, Pui C-H. A quantitative MRI assessment of leukoencephalopathy in children treated for acute lymphoblastic leukemia without irradiation. Am J Neuroradiol 26(9):2371-2377, 2005.

Last update: February 2016