Jason R. Schwartz, MD, PhD
Jason R. Schwartz, MD, PhD

Jason R. Schwartz, MD, PhD

Instructor, St. Jude Faculty

  • Physician Scientist Training Program (PSTP) Instructor

Departments

Education

BS - Louisiana College, Pineville, Louisiana
MD, PhD - Louisiana State University Health Sciences Center at New Orleans, New Orleans, Louisiana
General Pediatrics Residency - Monroe Carell Jr Children’s Hospital at Vanderbilt, Nashville, Tennessee            
Pediatric Hematology/Oncology Fellowship - St. Jude Children’s Research Hospital, Memphis, Tennessee
Physician Scientist Training Program (PSTP) Fellowship - St. Jude Children’s Research Hospital, Memphis, Tennessee

Research Interests

  • Genomic characterization of pediatric MDS
  • Mechanisms of SAMD9/L mutation associated pediatric MDS predisposition
  • Clonal evolution of pediatric therapy-related myeloid neoplasms

Selected Publications

Wong JC, Bryant V, Lamprecht T, Ma J, Walsh M, Schwartz JR, Alzamora M, Mullighan CG, Loh M. Ribeiro R, Downing JR, Carroll WL, Davis J, Gold S, Rogers PC, Israels S, Yanofsky R, Shannon K, Klco JM. Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes. J Clin Invest Insight Jul 25;3(14), 2018. PubMed PMID: 30046003.

Schwartz JR, Ma J, et al. The Genomic Landscape of Pediatric Myelodysplastic Syndromes. Nature Communications 8(1):1557, 2017. PubMed PMID: 29146900

Schwartz JR, Wang S, et al. Germline SAMD9 mutation in siblings with monosomy 7 and myelodysplastic syndrome. Leukemia 31(8):1827-30, 2017. PubMed PMID: 28487541

Schwartz JR, Walsh MP, Ma J, LamprechtT, Wang S, Wu G, Raimondi S, Triplett B, Klco J. Clonal Dynamics of Donor-Derived MDS after Unrelated-HCT for High-Risk Pediatric B-Lymphoblastic Leukemia. Cold Spring Harb Mol Case Stud Jun 11, 2018.  PubMED PMID:29891567

Miller AL, Geng C, Golovko G, Sharma M, Schwartz JR, Yan J, Sowers L, Widger WR, Fofanov Y, Vedeckis WV, Thompson EB. Epigenetic alteration by DNA-demethylating treatment restores apoptotic response to glucocorticoids in dexamethasone-resistant human malignant lymphoid cells. Cancer Cell Int 23(14):35, 2014.  PubMed PMID: 24795534

Schwartz JR, Sarvaiya PJ, Leiva LE, Velez MC, Singleton TC, Yu LC, Vedeckis WV. A facile, branched DNA assay to quantitatively measure glucocorticoid receptor auto-regulation in T-cell acute lymphoblastic leukemia. Chinese Journal of Cancer 31(8):381-91, 2012. PubMed PMID: 22739263

Sarvaiya PJ, Schwartz JR, Hernandez CP, Rodriguez PC, Vedeckis WV. Role of c-Myb in the survival of pre B-cell acute lymphoblastic leukemia and leukemogenesis. American Journal of Hematology 87(10):969-76, 2012.  PubMed PMID: 22764095

Schwartz JR, Sarvaiya PJ, Vedeckis WV. Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B-cell acute lymphoblastic leukemia. Mol & Cellular Endocrinol 320(1-2):76-86, 2010. PubMed PMID: 20170710

Sarvaiya PJ, Schwartz JR, Vedeckis WV. c-Myb interacts with the glucocorticoid receptor and regulates its level in pre-B-acute lymphoblastic leukemia cells. Mol & Cellular Endocrinol 361(1-2):124-32, 2012. PubMed PMID: 22516378

Geng C-d, Schwartz JR, Vedeckis WV. A conserved molecular mechanism is responsible for the auto-up-regulation of glucocorticoid receptor gene promoters. Mol Endocrinol 22(12):2624-42, 2008.  PubMed PMID: 18945813

Last update: September 2018