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Kumar Saurabh, PhD

Kumar Saurabh, PhD

  • Research Lab Specialist

Departments

Divisions

Education

MTech – Biotechnology, GGS Indraprastha University, Delhi, India
PhD – Biotechnology, CSIR-Indian Institute of Toxicology Research, Lucknow, India
Postdoc – University of Louisville, Kentucky, USA
Postdoc – Virginia Commonwealth University, Richmond, Virginia, USA

Honors & Awards

  • 2007 CSIR Research Fellowship, New Delhi, India
  • 2010 Guest Scientist, Indo-German Fellowship, Dortmund, Germany

Research Interests

I am a molecular biologist with research interest in understanding the mechanisms of gene alterations in cancer and exploring therapeutic targets. My current research is focused on elucidating how pathogenic germline ETV6 variants impair blood cell development and drive leukemogenesis. I use mouse genetic models and human induced pluripotent stem cell differentiation approaches to carry out these studies. I am also investigating the cooperative effects of ETV6 variants with other oncogenic drivers in promoting leukemia formation. I employ molecular, cellular and next generation sequencing technologies to address this question.

Selected Publications

Kurlawala Z*, Saurabh K*, Shah PP, Dunaway R, Siskind LJ, Beverly LJ. Ubiquilin proteins regulate EGFR levels and activity in lung adenocarcinoma cells. J Cell Biochem 122(1):43-52, 2021. *Equal Authors

Saurabh K, Shah PP, Doll MA, Siskind LJ, Beverly LJ. UBR-Box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target. BMC Cancer 20(1):824, 2020.

Lima S, Takabe K, Newton J, Saurabh K, Young MM, Leopoldino AM, Hait NC, Roberts JL, Wang HG, Dent P, Milstien S, Booth L, Spiegel S. TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition. Autophagy. 14:942-957, 2018.

Dupre TV, Doll MA, Shah PP, Sharp CN, Kiefer A, Scherzer MT, Saurabh K, Saforo D, Siow D, Casson L, Arteel GE, Jenson AB, Megyesi J, Schnellmann RG, Beverly LJ, Siskind LJ. Suramin protects from cisplatin-induced acute kidney injury. American Journal of Physiology - Renal Physiology 310:F248-58, 2016.

Shah PP, Lockwood WW, Saurabh K, Kurlawala Z, Shannon SP, Waigel S, Zacharias W, Beverly LJ. Ubiquilin1 represses migration and epithelial-to-mesenchymal transition of human non-small cell lung cancer cells. Oncogene 34:1709-17, 2015.

Saurabh K, Scherzer MT, Shah PP, Mims AS, Lockwood WW, Kraft AS, Beverly LJ. The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets. Oncotarget 5:8503-14, 2014.

Saurabh K, Scherzer MT, Song A, Yip KW, Reed JC, Li C, Beverly LJ. Dissecting the in vivo leukemogenic potency of BCLxl. Leukemia Research 2(5):158, 2014.

Sharma A*, Saurabh K*, Yadav S, Jain SK, Parmar D. Expression profiling of selected genes of toxication and detoxication pathways in peripheral blood lymphocytes as a biomarker for predicting toxicity of environmental chemicals. International Journal of Hygiene and Environmental Health 216:645-51, 2013. *Equal Authors

Sharma A, Saurabh K, Yadav S, Jain SK, Parmar D. Ethanol induced induction of cytochrome P450 2E1 and activation of mitogen activated protein kinases in peripheral blood lymphocytes. Xenobiotica 42:317-26, 2012.

Saurabh K, Parmar D. Evidence for cytochrome P450 2B1/2B2 isoenzymes in freshly prepared peripheral blood lymphocytes. Biomarkers 16:649-56, 2011.

Saurabh K, Sharma A, Yadav S, Parmar D. Polycyclic aromatic hydrocarbon metabolizing cytochrome P450s in freshly prepared uncultured rat blood lymphocytes. Biochemical Pharmacology 79:1182-8, 2010.

Shah PP, Saurabh K, Pant MC, Mathur N, Parmar D. Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients. Mutation Research 670:74-8, 2009.

Last update: February 2021