Scott E. Snyder, PhD
Scott E. Snyder, PhD

Scott E. Snyder, PhD

Associate Member, St. Jude Faculty

  • Director, Molecular Imaging Research

Departments

Divisions

Education

BS – Virginia Polytechnic Institute and State University, Blacksburg, VA (1986)
PhD – Purdue University, West Lafayette, IN (1993)

Research Interests

Development of novel radiopharmaceuticals for positron emission tomographic (PET) imaging. Particular PET imaging applications include:

  • Functional characterization of tumors
  • Therapy response monitoring
  • Investigation of therapy-induced neurological disorders in cancer survivors

Selected Publications

Davis JC, Daw NC, Navid F, Billups CA, Wu J, Bahrami A, Jenkins JJ, Snyder SE, Reddick WE, Santana VM, McCarville E, Guo J, Shulkin BL. FDG PET CT studies in pediatric patients with osteosarcoma: Comparison of early and delayed imaging with response to therapy. J Nucl Med 2017 (in press).

Linstad EJ, Vāvere AL, Hu B, Kempinger JJ, Snyder SE, DiMagno SG. Thermolysis and Radiofluorination of Diaryliodonium Salts Derived from Anilines. Org Biomol Chem 15:2246-2252, 2017. PMID: 28230886

Lucas JT, Serrano N, Kim H, Li X, Snyder SE, Hwang S, Li Y, Hua C-H, Broniscer A, Merchant TE, Shulkin BL. 11C-Methionine positron emission tomography delineates non-contrast enhancing tumor regions at high risk for recurrence in pediatric high-grade glioma. J Neuro-Onc 2017, epub ahead of print 1/11/2017.

Kaste SC, Snyder SE, Metzger ML, Sandlund JT, Howard SC, Krasin M, Shulkin BL. Comparison of 11C-methionine and 18F-FDG PET-CT for staging and follow-up of pediatric lymphoma. J Nucl Med 58:419-424, 2017. PMID:27609791

Jiao P, Otto M, Geng Q, Li C, Li F, Butch ER, Snyder SE, Zhou H, Yan B. Enhancing both CT imaging and natural killer cell-mediated cancer cell killing by a GD2-targeting nanoconstruct. J Materials Chem B 4:513-520, 2016. PMC4830492

Neumann KD, Qin L, Vavere AL, Shen B, Miao Z, Chin FT, Snyder SE, DiMagno SGEfficient automated synthesis of high specific activity 6-[18F]fluorodopamine using a diaryliodonium salt precursor. J Labelled Compd Radiopharm 59:30-34, 2016. PMC4715522

Hu* B, Vavere* AL, Neumann KD, DiMagno S, Snyder SE. A practical, automated synthesis of meta-[18F]fluorobenzylguanidine for clinical use. ACS Chem Neurosci 6(11):1870-1879, 2015. PMC4651823

Ostermeier A, McCarville MB, Navid F, Snyder SE, Shulkin BL. FDG PET/CT imaging of desmoplastic small round cell tumor: Findings as staging, during treatment and at follow up. Ped Radiol 45(9):1308-1315, 2015. PMC4529370

Stewart E, Goshorn R, Bradley C, Griffiths LM, Benavente C, Twarog NR, Miller GM, Caufield W, Freeman BB 3rd, Bahrami A, Pappo A, Wu J, Loh A, Karlström Å, Calabrese C, Gordon B, Tsurkan L, Hatfield MJ, Potter PM, Snyder SE, Thiagarajan S, Shirinifard A, Sablauer A, Shelat AA, Dyer MA. Targeting the DNA repair pathway in Ewing sarcoma. Cell Reports 9(3):829-841, 2014. PMC4386669

Harris SM, Davis JC, Snyder SE, Butch ER, Vāvere AL, Kocak M, Shulkin BL. Evaluation of the Biodistribution of [11C]Methionine in Children and Young Adults. J Nucl Med 54:1902-1908, 2013. PMC3924715

Laser BS, Merchant TE, Indelicato DJ, Hua C-H, Shulkin BL, Snyder SE. Evaluation of children with craniopharyngioma using carbon-11 methionine PET prior to proton therapy. Neuro-Oncology 15(4):506-510, 2013. PMC3607263

Vavere AL, Butch ER, Dearling JL, Packard, AB, Navid F, Shulkin BL, Barfield RC, Snyder SE. 64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET radiotracer targeting neuroblastoma and melanoma. J Nucl Med 53(11):1772-1778, 2012.

Vavere AL, *Snyder SE. Synthesis of L-[methyl-11C]methionine (11C-MET). In: Radiochemical Synthese, Scott PJ and Hockley B, eds. New York: John Wiley & Sons, pp 199-212, 2012.

Gao N, Zhang Q, Mu Q, Bai Y, Li L, Zhou H, Butch ER, Powell TB, Snyder SE, Jiang G, Yan B. Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity. ACS Nano 5:4581-4591, 2011.

Jiao P, Zhou H, Otto M, Mu Q, Li L, Su G, Zhang Y, Butch E, Snyder S, Jiang G, Yan B. Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct. J Am Chem Soc 133:13918-21, 2011.

Bai Y, Zhang Y, Zhang J, Mu Q, Zhang W, Butch ER, Snyder SE, Yan B. Repeated carbon nanotube administrations in male mice cause reversible testis damage without affecting fertility. Nature Nanotechnology 5:683-689, 2010.

Li X, Jung Y-W, Snyder SE, Blair J, Sherman PS, Desmond T, Frey KA, Kilbourn MR. 5-tert-Butyl-2-(4'-[18F]fluoropropynylphenyl)-1,3-dithiane oxides: Potential new GABAA receptor radioligands. Nucl Med Biol 35:549-59, 2008.

Kuhl DE, Koeppe RA, Snyder SE, Minoshima S, Frey KA, Kilbourn MR. In vivo butyrylcholinesterase activity is not increased in Alzheimer synapses. Ann Neurol 59:13-20, 2006.

Shao X, Koeppe RA, Butch ER, Kilbourn MR, Snyder SE*. Evaluation of 18F-labeled acetylcholinesterase substrates as PET radiotracers. Bioorg Med Chem 13:869-875, 2005.

Shao X, Butch ER, Kilbourn MR, Snyder SE*. N-[18F]Fluoroethylpiperidinyl, N-[18F]fluoroethylpiperidinemethyl and N-[18F]fluoroethylpyrrolidinyl esters as radiotracers for acetylcholinesterase. Nucl Med Biol 30:491-500, 2003.

Shao X, Lisi JM, Butch ER, Kilbourn MR, Snyder SE*. N-Methylpiperidinemethyl, N-methylpyrrolidyl and N-methylpyrrolidinemethyl esters as PET radiotracers for acetylcholinesterase activity. Nucl Med Biol 30:293-302, 2003.

Koeppe RA, Raffel DM, Snyder SE, Ficaro EP, Kilbourn MR, Kuhl DE. Dual-[11C]tracer single-acquisition positron emission tomography studies. J Cereb Blood Flow Metab 21:1480-1492, 2001.

Skaddan MB, Kilbourn MR, Snyder SE, Sherman PS. Acetylcholinesterase inhibition increases in vivo radioligand binding to muscarinic acetylcholine receptors. J Cereb Blood Flow Metab 21:144-148, 2001.

Snyder SE*, Gunupudi N, Sherman PS, Butch ER, Skaddan MB, Kilbourn MR, Koeppe RA, Kuhl DE. Radiolabeled cholinesterase substrates: In vitro methods for determining structure-activity relationships and identification of a positron emission tomography radiopharmaceutical for in vivo measurement of butyrylcholinesterase activity. J Cereb Blood Flow Metab 21:132-143, 2001.

Skaddan MB, Kilbourn MR, Snyder SE, Sherman PS, Desmond TJ, Frey KA. Synthesis, 18F-labeling and biological evaluation of piperidyl and pyrrolidyl benzilates as in vivo ligands for muscarinic acetylcholine receptors. J Med Chem 43:4552-4562, 2000.

Brown-Proctor C, Snyder SE, Sherman PS, Kilbourn MR. Synthesis and in vivo evaluation of (E)-N-[11C]methyl-4-(3-pyridinyl)-3-butene-1-amine ([11C]metanicotine) as a nicotinic receptor radioligand. Nucl Med Biol 27:415-418, 2000.

Kilbourn MR, Sherman PS, Snyder SE. Simplified methods for in vivo measurement of acetylcholinesterase activity in rodent brain. Nucl Med Biol 26:543-550, 1999.

Koeppe RA, Frey KA, Snyder SE, Meyer P, Kilbourn MR, Kuhl DE. Kinetic modeling of N-[11C]methylpiperidin-4-yl propionate: Alternatives for analysis of an irreversible PET tracer for measurement of acetylcholinesterase activity in human brain. J Cereb Blood Flow Met 19:1150-1163, 1999.

Snyder SE, Sherman PS, Frey KA, Desmond T, Kilbourn MR. (-)-[11C]6’,7’-Dihydroroten-12-ol ((-)-DHROL) for in vivo measurement of mitochondrial complex I. J Labeled Cmpds Radiopharm 42:641-652, 1999.

Kuhl DE, Koeppe RA, Minoshima S, Snyder SE, Ficaro EP, Foster NL, Frey KA, Kilbourn MR. In vivomapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease. Neurology52:691-699, 1999.

Brown-Proctor C, Snyder SE, Sherman PS, Kilbourn MR. Synthesis and evaluation of 6-[11C]methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole as an in vivo radioligand for acetylcholinesterase. Nucl Med Biol 26:99-103, 1999.

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Nguyen TB, Snyder SE, Kilbourn MR. Synthesis of carbon-11 labeled piperidine esters as potentialin vivo substrates for acetylcholinesterase. Nucl Med Biol 25:761-768, 1998.

Kilbourn MR, Nguyen TB, Snyder SE, Sherman P. N-[11C]Methylpiperidine esters as acetylcholinesterase substrates: An in vivo structure-activity study. Nucl Med Biol 25:755-760, 1998.

Snyder SE, Tluczek L, Jewett DM, Nguyen TB, Kuhl DE, Kilbourn MR. Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP) for in vivo measurements of acetylcholinesterase activity. Nucl Med Biol 25:751-754, 1998.

Bormans G, Sherman P, Snyder SE, Kilbourn MR. Synthesis of carbon-11 and fluorine-18 labeled 1-methyl-4-piperidyl 4'-fluorobenzoate and their biodistribution in mice. Nucl Med Biol 23:513-517, 1996.

Ghosh D, Snyder SE, Watts VJ, Mailman RB, Nichols DE. 8,9-Dihydroxy-2,3,7,11-tetrahydro-1H-naph[1,2,3-de]isoquinoline: A potent full dopamine D1 agonist containing a rigid -phenyl dopamine pharmacophore. J Med Chem 39:549-555, 1996.

Kilbourn MR, Snyder SE, Sherman PS, Kuhl DE. In vivo studies of acetylcholinesterase activity using a labeled substrate, N-[11C]methylpiperidin-4-yl propionate ([11C]PMP). Synapse 22:123-131, 1996.

Snyder SE, Kume A, Jung Y-W, Connor SE, Sherman P, Albin RL, Wieland DM, Kilbourn MR. Synthesis of carbon-11, fluorine-18-, and iodine-l25 labeled GABAA-gated chloride ion channel blockers: Substituted 5-tert-butyl-2-phenyl-1,3-dithianes and -dithiane oxides. J Med Chem 38:2663-2671, 1995.

Snyder SE, Avilles-Garay FA, Chakraborti R, Nichols DE, Watts VJ, Mailman RB. Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H-benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy-1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10-dihydro-1,2-dihydroxyanthracene as conformationally restricted analogs of ß-phenyldopamine. J Med Chem 38:2395-2409, 1995.

Nichols DE, Snyder SE, Oberlender R, Johnson MP, Huang X. 2,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines. J Med Chem 34:276-281, 1991.

Last update: August 2017