Scott E. Snyder, PhD
Scott E. Snyder, PhD

Scott E. Snyder, PhD

Associate Member, St. Jude Faculty

  • Director, Molecular Imaging Research




BS – Virginia Polytechnic Institute and State University, Blacksburg, VA (1986)
PhD – Purdue University, West Lafayette, IN (1993)

Research Interests

Development of novel radiopharmaceuticals for positron emission tomographic (PET) imaging. Particular PET imaging applications include:

  • Functional characterization of tumors
  • Therapy response monitoring
  • Investigation of therapy-induced neurological disorders in cancer survivors

Selected Publications

Vavere AL, Butch ER, Dearling JL, Packard, AB, Navid F, Shulkin BL, Barfield RC, Snyder SE. 64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET radiotracer targeting neuroblastoma and melanoma. J Nucl Med 53(11):1772-1778, 2012.

Vavere AL, *Snyder SE. Synthesis of L-[methyl-11C]methionine (11C-MET). In: Radiochemical Synthese, Scott PJ and Hockley B, eds. New York: John Wiley & Sons, pp 199-212, 2012.

Gao N, Zhang Q, Mu Q, Bai Y, Li L, Zhou H, Butch ER, Powell TB, Snyder SE, Jiang G, Yan B. Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity. ACS Nano 5:4581-4591, 2011.

Jiao P, Zhou H, Otto M, Mu Q, Li L, Su G, Zhang Y, Butch E, Snyder S, Jiang G, Yan B. Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct. J Am Chem Soc 133:13918-21, 2011.

Bai Y, Zhang Y, Zhang J, Mu Q, Zhang W, Butch ER, Snyder SE, Yan B. Repeated carbon nanotube administrations in male mice cause reversible testis damage without affecting fertility. Nature Nanotechnology 5:683-689, 2010.

Li X, Jung Y-W, Snyder SE, Blair J, Sherman PS, Desmond T, Frey KA, Kilbourn MR. 5-tert-Butyl-2-(4'-[18F]fluoropropynylphenyl)-1,3-dithiane oxides: Potential new GABAA receptor radioligands. Nucl Med Biol 35:549-59, 2008.

Kuhl DE, Koeppe RA, Snyder SE, Minoshima S, Frey KA, Kilbourn MR. In vivo butyrylcholinesterase activity is not increased in Alzheimer synapses. Ann Neurol 59:13-20, 2006.

Shao X, Koeppe RA, Butch ER, Kilbourn MR, Snyder SE*. Evaluation of 18F-labeled acetylcholinesterase substrates as PET radiotracers. Bioorg Med Chem 13:869-875, 2005.

Shao X, Butch ER, Kilbourn MR, Snyder SE*. N-[18F]Fluoroethylpiperidinyl, N-[18F]fluoroethylpiperidinemethyl and N-[18F]fluoroethylpyrrolidinyl esters as radiotracers for acetylcholinesterase. Nucl Med Biol 30:491-500, 2003.

Shao X, Lisi JM, Butch ER, Kilbourn MR, Snyder SE*. N-Methylpiperidinemethyl, N-methylpyrrolidyl and N-methylpyrrolidinemethyl esters as PET radiotracers for acetylcholinesterase activity. Nucl Med Biol 30:293-302, 2003.

Koeppe RA, Raffel DM, Snyder SE, Ficaro EP, Kilbourn MR, Kuhl DE. Dual-[11C]tracer single-acquisition positron emission tomography studies. J Cereb Blood Flow Metab 21:1480-1492, 2001.

Skaddan MB, Kilbourn MR, Snyder SE, Sherman PS. Acetylcholinesterase inhibition increases in vivo radioligand binding to muscarinic acetylcholine receptors. J Cereb Blood Flow Metab 21:144-148, 2001.

Snyder SE*, Gunupudi N, Sherman PS, Butch ER, Skaddan MB, Kilbourn MR, Koeppe RA, Kuhl DE. Radiolabeled cholinesterase substrates: In vitro methods for determining structure-activity relationships and identification of a positron emission tomography radiopharmaceutical for in vivo measurement of butyrylcholinesterase activity. J Cereb Blood Flow Metab 21:132-143, 2001.

Skaddan MB, Kilbourn MR, Snyder SE, Sherman PS, Desmond TJ, Frey KA. Synthesis, 18F-labeling and biological evaluation of piperidyl and pyrrolidyl benzilates as in vivo ligands for muscarinic acetylcholine receptors. J Med Chem 43:4552-4562, 2000.

Brown-Proctor C, Snyder SE, Sherman PS, Kilbourn MR. Synthesis and in vivo evaluation of (E)-N-[11C]methyl-4-(3-pyridinyl)-3-butene-1-amine ([11C]metanicotine) as a nicotinic receptor radioligand. Nucl Med Biol 27:415-418, 2000.

Kilbourn MR, Sherman PS, Snyder SE. Simplified methods for in vivo measurement of acetylcholinesterase activity in rodent brain. Nucl Med Biol 26:543-550, 1999.

Koeppe RA, Frey KA, Snyder SE, Meyer P, Kilbourn MR, Kuhl DE. Kinetic modeling of N-[11C]methylpiperidin-4-yl propionate: Alternatives for analysis of an irreversible PET tracer for measurement of acetylcholinesterase activity in human brain. J Cereb Blood Flow Met 19:1150-1163, 1999.

Snyder SE, Sherman PS, Frey KA, Desmond T, Kilbourn MR. (-)-[11C]6’,7’-Dihydroroten-12-ol ((-)-DHROL) for in vivo measurement of mitochondrial complex I. J Labeled Cmpds Radiopharm 42:641-652, 1999.

Kuhl DE, Koeppe RA, Minoshima S, Snyder SE, Ficaro EP, Foster NL, Frey KA, Kilbourn MR. In vivomapping of cerebral acetylcholinesterase activity in aging and Alzheimer’s disease. Neurology52:691-699, 1999.

Brown-Proctor C, Snyder SE, Sherman PS, Kilbourn MR. Synthesis and evaluation of 6-[11C]methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole as an in vivo radioligand for acetylcholinesterase. Nucl Med Biol 26:99-103, 1999.

Nguyen TB, Snyder SE, Kilbourn MR. Synthesis of carbon-11 labeled piperidine esters as potentialin vivo substrates for acetylcholinesterase. Nucl Med Biol 25:761-768, 1998.

Kilbourn MR, Nguyen TB, Snyder SE, Sherman P. N-[11C]Methylpiperidine esters as acetylcholinesterase substrates: An in vivo structure-activity study. Nucl Med Biol 25:755-760, 1998.

Snyder SE, Tluczek L, Jewett DM, Nguyen TB, Kuhl DE, Kilbourn MR. Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP) for in vivo measurements of acetylcholinesterase activity. Nucl Med Biol 25:751-754, 1998.

Bormans G, Sherman P, Snyder SE, Kilbourn MR. Synthesis of carbon-11 and fluorine-18 labeled 1-methyl-4-piperidyl 4'-fluorobenzoate and their biodistribution in mice. Nucl Med Biol 23:513-517, 1996.

Ghosh D, Snyder SE, Watts VJ, Mailman RB, Nichols DE. 8,9-Dihydroxy-2,3,7,11-tetrahydro-1H-naph[1,2,3-de]isoquinoline: A potent full dopamine D1 agonist containing a rigid -phenyl dopamine pharmacophore. J Med Chem 39:549-555, 1996.

Kilbourn MR, Snyder SE, Sherman PS, Kuhl DE. In vivo studies of acetylcholinesterase activity using a labeled substrate, N-[11C]methylpiperidin-4-yl propionate ([11C]PMP). Synapse 22:123-131, 1996.

Snyder SE, Kume A, Jung Y-W, Connor SE, Sherman P, Albin RL, Wieland DM, Kilbourn MR. Synthesis of carbon-11, fluorine-18-, and iodine-l25 labeled GABAA-gated chloride ion channel blockers: Substituted 5-tert-butyl-2-phenyl-1,3-dithianes and -dithiane oxides. J Med Chem 38:2663-2671, 1995.

Snyder SE, Avilles-Garay FA, Chakraborti R, Nichols DE, Watts VJ, Mailman RB. Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H-benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy-1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10-dihydro-1,2-dihydroxyanthracene as conformationally restricted analogs of ß-phenyldopamine. J Med Chem 38:2395-2409, 1995.

Nichols DE, Snyder SE, Oberlender R, Johnson MP, Huang X. 2,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines. J Med Chem 34:276-281, 1991.

Last update: February 2013