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Santhosh Upadhyaya, MD
Santhosh Upadhyaya, MD

Santhosh Upadhyaya, MD

Assistant Member, St. Jude Faculty




MD – Kasturba Medical College, Manipal University, India
Pediatric Residency – Kasturba Medical College, Manipal University, India
Pediatric Residency – St. John Hospital Medical Center, Detroit, MI
Pediatric Hematology Oncology Fellowship – University of Michigan, Ann Arbor, MI
Pediatric Neuro-Oncology Fellowship  St. Jude Children’s Research Hospital, Memphis, TN

Research Interests

Clinical trials for Atypical Teratoid Rhabdoid Tumor (AT/RT) and Ependymoma- Our understanding of the process of pediatric brain tumor development has significantly enhanced in recent years due to advances in the genetic and molecular techniques used to study these tumors.  My goal is to apply these advances in formulating clinical trials to improve survival and reduce long term side effects in children with Atypical Teratoid Rhabdoid tumor (AT/RT) and Ependymoma.

Clinical Interests

  • Atypical Teratoid Rhabdoid tumor (AT/RT)
  • Ependymoma
  • Infant brain tumors

Selected Publications

Chiang J, Dalton J, Upadhyaya SA et al. Chromosome arm 1q gain is an adverse prognostic factor in localized and diffuse leptomeningeal glioneuronal tumors with BRAF gene fusion and 1p deletion. Acta Neuropathol.2019 Jan;137(1):179-181

Upadhyaya SA, Robinson GW et al. Molecular grouping and outcomes of young children with newly diagnosed ependymoma treated on the multi-Institutional SJYC07 trial. Neuro Oncol. 2019 Apr 12. doi: 10.1093/neuonc/noz069.

Quinn EA, Maciaszek JL, Pinto EM, Phillips AH, Berdy D, Khandwala M, Upadhyaya SA et al. From uncertainty to pathogenicity: Clinical and functional interrogation of a rare TP53 in-frame deletion. Cold Spring Harb Mol Case Stud. 2019 Mar 18. doi: 10.1101/mcs.a003921. [Epub ahead of print]

Upadhyaya SA, McGee RB, Wilky BA, Broniscer A. Malignant progression of a peripheral nerve sheath tumor in the setting of rhabdoid tumor predisposition syndrome. Pediatr Blood Cancer. 2018 Jul;65(7):e27030

Sengupta S, Weyand AC, Upadhyaya SA, Wu YM, Robinson DR, Mody RJ. Clinical implications of real-time integrative sequencing in management of patients with suspected germline BAP1 mutations. J Pediatr Hematol Oncol 2018 Mar 16. [Epub ahead of print]

Lin B, Kesserwan C, Quinn EA, Einhaus SL, Wright KD, Azzato EM, Orr BA, Upadhyaya SA. Anaplastic astrocytoma in a child With Coffin-Siris syndrome and a germline SMARCE1 mutation: A case report. J Pediatr Hematol Oncol. 2018 Nov 28. [Epub ahead of print]

Upadhyaya SA, Robinson GW, Harreld JH, Klimo PD Jr, Hoehn ME, Orr BA, Qaddoumi IA. Marked functional recovery and imaging response of refractory optic pathway glioma to BRAFV600E inhibitor therapy: a report of two cases. Childs Nerv Syst Feb 1, 2018. [Epub ahead of print]

Upadhyaya SA, Ghazwani Y, Wu S, et al. Mortality in Children with Low-Grade Glioma or Glioneuronal Tumors: A Single-Institution Study. Pediatr Blood Cancer  Jan;65(1), 2018. doi: 10.1002/pbc.26717

Upadhyaya SA, Mody R, Walkovich K, Hutchinson RJ, Sandlund JT, Connelly JA. Ataxia Telangiectasia and Cancer Predisposition: Challenges in Management. J Pediatr Hematol Oncol Dec 1, 2017. [Epub ahead of print]

Upadhyaya SA, Klimo Jr P, Robinson GW. Non-Malignant Cerebrospinal Fluid Ascites in a Patient with Atypical Teratoid Rhabdoid Tumor. Oncol Res Treat 40:216-219, 2017.

Upadhyaya SA, Koschmann C, Muraszko K et al. Brainstem Low-Grade Gliomas in Children-Excellent Outcomes With Multimodality Therapy. J Child Neurol Feb;32(2):194-203, 2017.

Koschmann C, Bloom K, Upadhyaya S, Geyer, JR, Leary, SES.  Survival after relapse of medulloblastoma. J Pediatr Hematol Oncol May;38(4):269-73, 2016.

Last update: October 2019