Xusheng Wang, PhD

Xusheng Wang, PhD

  • Group Lead - Bioinformatics Analysis



BS – Zhejiang University, China (2000)
PhD – Zhejiang University, China & University of California, Davis (2006)
Postdoctoral Fellowship and Research Associate – University of Tennessee Health Science Center (2008-2011)

Research Interests

  • Bioinformatics and computational biology
  • Systems biology, integrative biology
  • Computational proteomics and metabolomics
  • Quantitative genetics and Statistical Genomics
  • Genetics of complex diseases

Selected Publications

See Dr. Wang's publication on Google Scholar.

Wang X*, Jones D, Shaw T, Cho JH, Wang Y, Tan H, Xie B, Zhou S, Li Y, Peng J. Target-decoy Based False Discovery Rate Estimation for Large-scale Metabolite Identification. May 2018, Journal of proteome research. DOI: 10.1021/acs.jproteome.8b00019. *co-corresponding author

Luo J, Xu P, Cao P, Wan H, Lv X, Xu S, Wang G, Cook MN, Jones BC, Lu L, Wang X*. Integrating Genetic and Gene Co-expression Analysis Identifies Gene Networks Involved in Alcohol and Stress Responses. Frontiers in molecular neuroscience 11:102, 2018. *corresponding author

Tan H, Yang K, Li Y, Shaw T, Wang Y, Blanco DB, Wang X, Cho JH, Wang H, Rankin S, Guy C, Peng J, Chi H. Integrative proteomics and phosphoproteomics profiling reveals dynamic signaling networks and bioenergetics pathways underlying T cell activation. Immunity 46:488-50, 2017.

Scott D,  Hammill J,  Min J,  Rhee D,  Connelly M,  Sviderskiy V,  Bhasin D,  Chen Y,  Ong S,  Chai S,  Goktug A,  Huang G,  Monda J,  Low J,  Kim H,  Paulo J,  Cannon J,  Shelat A,  Chen T,  Kelsall I,  Alpi A,  Pagala V,  Wang X,  Peng J,  Singh B,  Harper J,  Schulman B,  Guy R. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nature chemical biology 13(8):850-7, 2017.

Wang X, Pandey A, Mulligan M, Williams E, Mozhui K, Li Z, Jovaisaite V, Quarles LD, Xiao Z, Huang J, Capra J, Chen Z, Taylor WL, Bastarache L, Niu X, Pollard KS, Ciobanu DC, Reznik AO, Tishkov AV, Zhulin IB, Peng J, Nelson SF, Denny JC, Auwerx J, Lu L, Williams RW. Joint mouse–human phenome-wide association to test gene function and disease risk. Nature communications 7:10464, 2016.

Wang X, Li Y, Wu Z, Wang H, Tan H, Peng J. JUMP: a tag-based database search tool for peptide identification with high sensitivity and accuracy. Molecular & cellular proteomics 13(12):3663-73, 2014.

Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J. U1 Small Nuclear Ribonucleoprotein Complex and RNA Splicing Alterations in Alzheimer’s Disease. Proc Natl Acad Sci USA 110:16562-7, 2013.

Wang X, Mozhui K, Li Z, Mulligan MK, Ingels JF, Zhou X, Hori RT, Chen H, Cook MN, Williams RW, Lu L. A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. Translational psychiatry 2(1):e73, 2012.

Wang X, Agarwala R, Capra JA, Chen Z, Church DM, Ciobanu DC, Li Z, Lu L, Mozhui K, Mulligan MK, Nelson SF. High-throughput sequencing of the DBA/2J mouse genome. BMC bioinformatics 11(4):O7, 2010.

Wang X, Chen Y, Wang X, Lu L. Genetic regulatory network analysis for app based on genetical genomics approach. Experimental aging research 36(1):79-93, 2009.

Wang X, Zhang M, Zhu J, Geng S. Spectral prediction of Phytophthora infestans infection on tomatoes using artificial neural network (ANN). International Journal of Remote Sensing 29(6):1693-706, 2008.

Wang X, Zhu H, Jin G, Liu H, Wu W, Zhu J. Genome-scale identification and analysis of LEA genes in rice (Oryza sativa L.). Plant Science 172(2):414-20, 2007.

Wang X, Zhao X, Zhu J, Wu W. Genome-wide investigation of intron length polymorphisms and their potential as molecular markers in rice (Oryza sativa L.). DNA research 12(6):417-27, 2005.

Last update: June 2018