Hui Zhang, PhD
Hui Zhang, PhD

Hui Zhang, PhD

Associate Member, St. Jude Faculty



BS – Nankai University
MS – Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences
MS – University of Rochester
PhD – University of Rochester

Research Interests

  • Missing data
  • Longitudinal discrete data analysis
  • U-statistics
  • Survival analysis
  • Computational neuroscience
  • Count data in next generation sequencing 

Selected Publications

Zhang Z, Chen R, Soon G, Zhang H. Treatment Evaluation for a Data-Driven Subgroup in Adaptive Enrichment Designs of Clinical Trials. Statistics in Medicine 37(1):1-11, 2018. doi: 10.1002/sim.7497

Liu W, Zhang B, Zhang H, Zhang Z.Likelihood-Based Methods for Evaluating Principal Surrogacy in Augmented Vaccine Trials. Statistical Method in Medical Research 26(2):984-996, 2017. doi: 10.1177/0962280214565833

Liu W, Zhang Z, Pantoja-Galicia N, Zhang B, Kotz RM, Pennello G, Zhang H, Jacob J, Campbell G. Generalized Linear Mixed Models for Multi-Reader Multi-Case Studies of Diagnostic Tests. Statistical Method in Medical Research 26(3):1373-1388, 2017. doi: 10.1177/0962280215579476

Zhang H*, He H, Lu N, Zhu L, Zhang B, Zhang Z, Tang L. A non-parametric model to address overdispersed count response in a longitudinal data setting with missingness. Statistical Method in Medical Research 26(3):1461-1475, 2017. doi: 10.1177/0962280215583397

Liu X, Winter B, Tang L, Zhang B, Zhang H*. Simulating comparisons of different computing algorithms fitting zero-inflated Poisson models for zero abundant counts. Journal of Statistical Computation and Simulation 87:2609-2621, 2017. DOI: 10.1080/00949655.2017.1327590

Conklin HM, Ashford JM, Clark KN, Martin-Elbahesh K, Hardy KK, Merchant TE, Ogg RJ, Jeha S, Huang L, Zhang H. Long-term Efficacy of Computerized Cognitive Training among Survivors of Childhood Cancer: A Single-Blind Randomized Controlled Trial. Journal of Pediatric Psychology 42(2):220-231, 2017. doi: 10.1093/jpepsy/jsw057 (the 2017 Diane J. Willis Award for Outstanding Article in the Journal of Pediatric Psychology)

Willard VW, Qaddoumi I, Zhang H, Huang L, Russell KM, Brennan R, Wilson MW, Rodriguez-Galindo C, Phipps S. A Longitudinal Investigation of Parenting Stress in Caregivers of Children with Retinoblastoma. Pediatric Blood & Cancer 64(4), 2017. doi: 10.1002/pbc.26279

Klosky JL, Anderson LE, Russell KM, Huang L, Zhang H, Schover LR, Simmons J, Kutteh WH. Provider Influences on Sperm Banking Outcomes among Adolescent Males Newly Diagnosed with Cancer. Journal of Adolescent Health 60(3):277-283, 2017. doi: 10.1016/j.jadohealth.2016.10.020

Niu M, Cho JH, Kodali K, Pagala V, High AA, Wang H, Wu Z, Li Y, Bi W, Zhang H, Wang X, Zou W,  Peng J. Extensive Peptide Fractionation and y1 Ion-based Interference Detection Enable Accurate Quantification by Isobaric Labeling Mass Spectrometry. Analytical Chemistry 89(5):2956-2963, 2017. doi: 10.1021/acs.analchem.6b04415

Fournier-Goodnight AS, Ashford JM, Merchant TE, Boop FA, Indelicato DJ, Wang L, Zhang H, Conklin HM. Neurocognitive Functioning in Pediatric Craniopharyngioma: Performance before Treatment with Proton Therapy. Journal of Neuro-Oncology 134:97-105, 2017. doi: 10.1007/s11060-017-2492-y

Qu F, Yan W, Chen Y, Li K, Zhang H, Fu X. “You should have seen the look on your face…”: Self-awareness of Facial Expressions. Frontiers in Psychology 8:832, 2017. doi: 10.3389/fpsyg.2017.00832

Klosky JL, Huang L, Zhang H, Russell KM, Wasilewski-Masker K, Landier W, Leonard M, Albritton KH, Gupta AA, Casillas J, Colte P, Simmons JL, Kutteh WH, Schover LR. Prevalence and Predictors of Sperm Banking in Adolescents Newly Diagnosed with Cancer: Examination of Adolescent, Parent and Provider Factors Influencing Fertility. Journal of Clinical Oncology 35(34):3830-3836, 2017. doi: 10.1200/JCO.2016.70.4767

Schreiber JE, Palmer SL, Conklin HM, Mabbott DJ, Swain MA, Bonner MJ, Chapieski ML, Huang L, Zhang H, Gajjar A. Posterior fossa syndrome and long-term neurobehavioral problems among children treated for medulloblastoma on a multi-institutional, prospective study. Journal of Neuro-Oncology 19(12):1673-1682, 2017. doi: 10.1093/neuonc/nox135

Klosky JL, Simmons JL, Lehmann V, Russell KM, Wang F, Hardin RN, Eddinger JR, Zhang H, Dahlke LAM, Schover LR. Parental influences on sperm banking attempts among adolescent males newly diagnosed with cancer. Fertility and Sterility 108(6):1043-1049, 2017. doi: 10.1016/j.fertnstert.2017.08.039

Fournier-Goodnight AS, Ashford JM, Clark KN, Martin-Elbahesh K, Hardy KK, Merchant TE, Jeha S, Ogg RJ, Zhang H, Wang L, Conklin HM. Disseminability of Computerized Cognitive Training: Performance across Coaches. Applied Neuropsychology: Child 21:1-10, 2017. doi: 10.1080/21622965.2017.1394853

Huang L, Tang L, Zhang B, Zhang Z, Zhang H*. Comparison of Different Computational Implementations on Fitting Generalized Linear Mixed-effects Models for Repeated Count Measures. Journal of Statistical Computation and Simulation 87:2392-2404, 2016. doi: 10.1080/00949655.2015.1111376

Zhang B, Liu W, Zhang H, Zhang Z. Composite likelihood and maximum likelihood methods for joint latent class modeling of disease prevalence and high-dimensional semicontinuous biomarker data. Computational Statistics 31:425-449, 2016. doi: 10.1007/s00180-015-0597-3 (the only winner of Computational Statistics papers for 2016 Springer Change-the-World campaign)

Liu W, Zhang Z, Schroeder RJ, Zhang B, Zhang H, Ho M, Kotz R, Irony T. Joint Estimation of Treatment and Placebo Effects in Clinical Trials with Longitudinal Blinding Assessments. Journal of the American Statistical Association 111:538-548, 2016.

Zhang Z, Chu J, Rahardja D, Zhang H, Tang L. Responder Analysis Without Dichotomization. Journal of Biopharmaceutical Statistics 26(6):1125-1135, 2016. doi: 10.1080/10543406.2016.1226325

Graef DM, Phipps S, Parris KR, Huang L, Zhang H, Crabtree VM. Sleepiness, Fatigue, Behavioral Functioning, and Quality of Life in Survivors of Childhood Hematopoietic Stem Cell Transplant. Journal of Pediatric Psychology 41(6):600-609, 2016. doi: 10.1093/jpepsy/jsw011

Zhao Y, Zhang H, Zhao J, Chen Y, Zhong Q and Zhang G. Evolution of infectious bronchitis virus in China over the past 20 years. Journal of General Virology 97(7):1566-1574, 2016. doi: 10.1099/jgv.0.000464

Show More

Chen T, Wu P, Tang W, Zhang H, Feng C, Kowalski J, Tu X. Variable Selection for Distribution-free Models for Longitudinal Zero-inflated Count Responses. Statistics in Medicine 35(16):2770-2785, 2016. DOI: 10.1002/sim.6892

Chen T, Lu N, Arora J, Katz I, Bossarte R, He H, Xia Y, Zhang H, Tu XM. Power Analysis for Cluster Randomized Trials with Binary Outcomes Modeled by Generalized Linear Mixed-effects Models. Journal of Applied Statistics 43(6):1104-1118, 2016.

Chen T, Kowalski J, Chen R, Wu P, Zhang H, Feng C, Tu XM. Rank-preserving regression for longitudinal data with missing responses. Statistics in Medicine 35:3333-3346, 2016. DOI: 10.1002/sim.6930

Zhang B, Liu W, Zhang H, Chen Q, Zhang Z. A Note on Misspecification in Joint Modeling of Correlated Data with Informative Cluster Sizes. Journal of Statistical Planning and Inference 170:46-63, 2016. doi:10.1016/j.jspi.2015.09.005

Conklin HM, Ogg RJ, Ashford JM, Scoggins MA, Zou P, Clark KN, Martin-Elbahesh K, Hardy KK, Merchant TE, Jeha S, Huang L, Zhang H. Computerized Cognitive Training for Amelioration of Cognitive Late Effects among Childhood Cancer Survivors: A Randomized Controlled Trial. Journal of Clinical Oncology 33(33): 3894-3902, 2015. doi: 10.1200/JCO.2015.61.6672

Peck KR, Tyc VL, Huang Q, Zhang H. Reduction of Secondhand Smoke Exposure in the Cars of Children with Cancer. Journal of Pediatric Oncology Nursing 32(6):401-409, 2015. doi: 10.1177/1043454214563755

Phipps S, Long A, Willard V, Okado Y, Hudson M, Huang Q, Zhang H, Noll R. Parents of Children with Cancer: At-Risk or Resilient? Journal of Pediatric Psychology 40(9):914-925, 2015. doi: 10.1093/jpepsy/jsv047

Cox LE, Ashford JM, Clark KN, Martin-Elbahesh K, Hardy KK, Merchant TE, Ogg RJ, Jeha S, Willard VW, Huang L, Zhang H, Conklin HM. Feasibility and Acceptability of a Remotely-Administered Computerized Intervention to Address Cognitive Late Effects among Childhood Cancer Survivors. Neuro-Oncology Practice 2(2):78-87, 2015. doi: 10.1093/nop/npu036

Willard VW, Conklin HM, Huang L, Zhang H, Kahalley LS. Concordance of Parent-, Teacher- and Self-Report Ratings on the Conners 3 in Adolescent Survivors of Cancer. Psychological Assessment 28(9):1110-1118, 2016. doi: 10.1037/pas0000265. PubMed PMID: 27537005; PubMed Central PMCID: PMC4991558

Qin L, Ma S, Huang YT, Zhang H, Cao H. Array Platform Modeling and Analysis (A). Cancer Informatics 13(S4):91–93, 2014 doi: 10.4137/CIN.S22973

Lu N, Chen T, Wu P, Gunzler D, Zhang H, He H, Tu XM, Kowalski J. Functional Response Models for Intra-class Correlation Coefficients. Journal of Applied Statistics41(11):2539-2556, 2014. DOI: 10.1080/02664763.2014.920780

Nicholson JS, McDermott MJ, Huang Q, Zhang H, Tyc VL. Full and home smoking ban adoption after a randomized controlled trial targeting second-hand smoke exposure reduction. Nicotine & Tobacco Research 17(5):612-616, 2015. doi: 10.1093/ntr/ntu201.

Pu J, Wang S, Yin Y, Zhang G, Carter RA, Wang J, Xu G, Sun H, Wang M, Wen C, Wei Y, Wang D, Zhu B, Lemmon G, Jiao Y, Duan S, Wang Q, Du Q, Sun M, Bao J, Sun Y, Zhao J, Zhang H, Wu G, Liu J, Webster RG. Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus. PNAS, Proceedings of the National Academy of Sciences 112:548-553, 2015. doi: 10.1073/pnas.1422456112.

Willard VW, Qaddoumi I, Chen S, Zhang H, Brennan R, Rodriguez-Galindo C, Wilson MW, Phipps S. Developmental and Adaptive Functioning in Children with Retinoblastoma: A Longitudinal Investigation.Journal of Clinical Oncology 32:2788-2793, 2014. doi: 10.1200/JCO.2013.53.1996.

Willard VW, Leung W, Huang Q, Zhang H, Phipps S. Cognitive Outcome After Pediatric Stem-Cell Transplantation: Impact of Age and Total-Body Irradiation. Journal of Clinical Oncology 32:3982-3988, 2014. doi: 10.1200/JCO.2014.56.2223.

Chen R, Chen T, Lu N, Zhang H, Wu P, Feng C and Tu XM. Extending the Mann-Whitney-Wilcoxon Rank Sum Test to longitudinal data analysis with covariates. Journal of Applied Statistics 41(12):2658-2675, 2014. doi: 10.1080/02664763.2014.925101.

Khatoon Z, Figler B, Zhang H, Cheng F. Introduction to RNA-Seq and Its Application to Drug Discovery and Development. Drug Development Research 75:324-330, 2014.

Lu N, Chen T, Wu P, Gunzler D, Zhang H, He H, Tu XM, and Kowalski J. Functional Response Models for Intra-class Correlation Coefficients. Journal of Applied Statistics 41(11):2539-2556, 2014. doi: 10.1080/02664763.2014.920780.

Knight SJ, Conklin HM, Schreiber J, Palmer S, Armstrong CL, Wallace D, Bonner M, Swain MA, Chapieski L, Mabbott D, Boyle R, Huang Q, Zhang H, Anderson V, Gajjar A. Working memory abilities among children treated for medulloblastoma: Parent report and child performance. Journal of Pediatric Psychology 39:501-511, 2014. doi: 10.1093/jpepsy/jsu009.

Schreiber JE, Gurney JG, Palmer SL, Bass JK, Wang M, Chen S, Zhang H, Swain M, Chapieski ML, Bonner MJ, Mabbott DJ, Knight SJ, Armstrong CL, Boyle R, Gajjar A. Examination of Risk Factors for Intellectual and Academic Outcomes following Treatment for Pediatric Medulloblastoma. Neuro-Oncology 16:1129-1136, 2014. doi: 10.1093/neuonc/nou006.

Bettini M, Blanchfield JL, Castellaw A, Zhang Q, Nakayama M, Smeltzer MP, Zhang H, Hogquist KA, Evavold BD, Vignali DA. TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential. Journal of Immunology 193:571-579, 2014. doi: 10.4049/jimmunol.

Phipps S, Klosky J, Long A, Hudson M., Huang Q, Zhang H, Noll RB. Perception of Cancer as Traumatic Event, Posttraumatic Stress, and Psychological Growth in Children with Cancer. Journal of Clinical Oncology 32(7):641-646, 2014. doi: 10.1200/JCO.2013.49.8212.

Lindwall JJ, Russell K, Huang Q, Zhang H, Vannatta K, Barrera M, Alderfer M, Phipps S. Adjustment in Parents of Children Undergoing Stem Cell Transplantation. Biology of Blood and Marrow Transplant 20:543-548, 2014. doi: 10.1016/j.bbmt.2014.01.007

Gunzler D, Chen T, Wu P, Zhang H. Introduction to Mediation Analysis with Structural Equation Modeling. Shanghai Archives of Psychiatry 25(6):390-394, 2013. doi: 10.3969/j.issn.1002-0829.2013.06.009.

Zhang H, Holden-Wiltse J, Wang J, Liang H. A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC50. Plos One 8(8):e69301, 2013. doi:10.1371/journal.pone.0069301.

Tyc VL, Huang Q, Nicholson J, Schultz B, Hovell MF, Lensing S, Vukadinovich C, Hudson MM, Zhang H. Intervention to Reduce Secondhand Smoke Exposure Among Children with Cancer: A Controlled Trial. Psycho-Oncology 22:1104-1111, 2013. doi:0.1002/pon.3117.

Guy CS, Vignali KM, Temirov J, Bettini M, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Aifantis I, Davis MM, Vignali DA. Distinct T cell receptor signaling pathways drive proliferation and cytokine production in T cells. Nature Immunology 14:262-270, 2013.

Zhu L, Zhao H, Sun J, Pounds S, Zhang H. Joint Analysis of Longitudinal Data and Recurrent Episodes Data with Application to Medical Cost Analysis. Biometrical Journal55:5-16, 2013.

Zhang H, Yu Q, Feng C, Gunzler D, Wu P, Tu XM. A new look at the difference between the GEE and the GLMM when modeling longitudinal count responses. Journal of Applied Statistics 39:2067-2079, 2012.

Pounds SB, Gao CL, Zhang H. Empirical Bayesian Selection of Hypothesis Testing Procedures for Analysis of Sequence Count Expression Data. Statistical Applications in Genetics and Molecular Biology 11(5), 2012. doi: 10.1515/1544-6115.1773.

Brinkman T, Palmer SL, Chen S, Zhang H, Chapieski L, Swain M, Bonner MJ, Janzen L, Knight S, Armstrong CL, Boyle R, Gajjar A. Parent-Reported Social Outcomes After Treatment for Pediatric Embryonal Tumors: A Prospective Longitudinal Study. Journal of Clinical Oncology 30:4134-4140, 2012.

Zhang H, Lu N, Feng C, Thurston SW, Xia Y, Tu XM. On Fitting Generalized Linear Mixed-effects Models for Binary Responses using Different Statistical Packages. Statistics in Medicine 30:2562-2572, 2011.

Zhang H, Xia Y, Chen R, Lu N, Tang W, Tu XM. On Modeling Longitudinal Binomial Responses: Implications from Two Dueling Paradigms. Journal of Applied Statistics38:2373-2390, 2011.

Liang Z, Sun J, Srivastava DK, Tong X, Leisenring W, Zhang H, Robison LL. Semiparametric Transformation Models for Joint Analysis of Multivariate Recurrent and Terminal Events. Statistics in Medicine 30:3010-3023, 2011.

Yu Q, Tang W, Marcus S, Ma Y, Zhang H, Tu XM. Modeling Sensitivity and Specificity with a Time-varying Reference Standard within a Longitudinal Setting. Journal of Applied Statistics 37:1213-1230, 2010.

Ma Y, Gonzalez Della Valle A, Zhang H, Tu XM. A U-statistics based Approach for Modeling Cronbach Coefficient Alpha within a Longitudinal Data Setting. Statistics in Medicine 29:659-670, 2010.

Feng C, Zhang H, Tu XM. A Duality of Sample Size Calculation Based on Odds Ratio and on Risk Difference. JP Journal of Biostatistics 4:203-212, 2010.

Lu N, Tang W, He H, Yu Q, Crits-Christoph P, Zhang H, Tu XM. On the Impact of Parametric Assumptions and Robust Alternatives for Longitudinal Data Analysis.Biometrical Journal 51:627-643, 2009.

Moss AJ, Hall WJ, et al. (Zhang H  was listed as a biostatistician for MADIT-CRT Trial.) Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events. New England Journal of Medicine 361:1329-1338, 2009.

Ji XH, Ji JZ, Zhang H, Li BM. Stimulation of alpha2-adrenoceptors suppresses excitatory synaptic transmission in the medial prefrontal cortex of rat. Neuropsychopharmacology33:2263-2271, 2008.

Zhang H, Ameen N, Melvin JE, Vidyasagar S. Acute Inflammation Alters Bicarbonate Transport in Mouse Ileum. Journal of Physiology 581:1221-33, 2007.

Basavappa S, Vulapalli SR, Zhang H, Yule D, Coon S, Sundaram U. Chloride channels in the small intestinal cell line IEC-18. Journal of Cellular Physiology 202:21-31, 2005.

Zhang XH*, Zhang H*, Tu Y*, Gao X, Zhou C, Jin M, Zhao G, Jing N, Li BM, Yu L. Identification of a novel protein for memory regulation in the hippocampus.Biochemistry and Biophysics Research Communication 334:418-424, 2005. *Co-first authors.

Zhang H, Mitchell DR. Cpc1, a Chlamydomonas central pair protein with an adenylate kinase domain. Journal of Cell Science 117:4179-4188, 2004. *Comments in Journal of Cell Science. 117:1802.

Wang M, Zhang H, Li BM. Deficit in conditional visuomotor learning by local infusion of bicuculline into the ventral prefrontal cortex in monkeys. European Journal of Neuroscience 12:3787-96, 2000.

Last update: January 2018