Jian Zuo, PhD
Jian Zuo, PhD


BS – Huazhong University of Science & Technology, Wuhan, People's Republic of China (1985)
MS – Huazhong University of Science & Technology, Wuhan, People's Republic of China
PhD – University of California, San Francisco, CA (1993)

Honors & Awards

  • 2011 The Wennergren Foundation Award, Stockholm, Sweden
  • 2009-2012 The Hartwell Foundation 2009 Biomedical Research Collaboration Award, USA
  • 2007-2010 Hartwell Individual Biomedical Research Award, USA
  • 2004 The Richard J. Bellucci Award for Excellence in Research on Hearing and Vestibular Science and Disorders, Creighton University, Omaha, NE, USA
  • 1999-2001 March of Dimes Basil O’Connor Starter Scholar Research Award, USA

Research Interests

Hair cells function and regeneration in the mouse inner ear has been the main focus of my research.

Selected Publications

Teitz T, Goktug A, Chen T, Zuo J. Development of cell-based high-throughput chemical screens for protection against cisplatin-induced ototoxicity, in Auditory Vestibular Research Methods, Springer Verlag Publishers, 2016, See http://www.springer.com/us/book/9781493936137, ISBN 978-1-4939-3615-1

Zhang J, Liu Z, Tian Y, Men Y, Liu X*, Zuo J*, Gao J*, Abnormal mRNA Splicing but normal auditory brainstem response (ABR) in mice with the prestin mutation IVS2-2A/G. Mutation Research May 12;790:1-7, 2016. doi: 10.1016/j.mrfmmm.2016.05.004. [Epub ahead of print] PMID: 27232762 (* co-corresponding authors).

Layman WS, Zuo J.  Preventing ototoxic hearing loss by inhibiting histone deacetylases. Cell Death Diseases Sep 10;6:e1882. 2015. PMCID:PMC4650447

Walters Brandon J, Diao S, Zheng F, Walters Bradley J, Layman WS, Zuo J. Pseudo-immortalization of postnatal cochlear stem cells yields a scalable cell line capable of transcriptionally regulating mature hair cell genes. Sci Reports 5:17792, 2015. PMCID: PMC4671002

Iconaru LI, Baratham K, Ramanathan A, Zhang W, Shelat A, Zuo J*, Kriwacki RW*. Discovery of small molecules that inhibit the disordered protein, p27Kip1. Sci Reports 5:15686, 2015. (* co-corresponding authors). PMCID: PMC4623604

Yamashita T, Hakizimana P, Wu S, Hassan A, Jacob S, Jamshid T, Fang J, Mellado-Lagarde M, Gursky R, Horner L, Leibiger B, Leijon S, Centonze VE, Berggren P, Frase S, Auer M, Brownell WE, Fridberger A, Zuo J. Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins. PLoS Genetics 11(9):e1005500, 2015. PMCID: PMC4564264

Kuo BR, Baldwin E, Layman WS, Taketo MM, Zuo J. In vivo cochlear hair cell generation and survival by co-activation of β-catenin and Atoh1. J Neurosci 35(30): 10786-98, 2015. PMCID: PMC4518053

Layman WS, Williams DM, Dearman JA, Sauceda MA, Zuo J. Histone deacetylase inhibition protects hearing against acute ototoxicity by activating the Nf-κB pathway. Cell Death Discovery 1: 15012, 2015. PMCID: PMC4536828

Walters Bradley J, Yamashita T, Zuo J. Sox2-CreER mice are useful for fate mapping of mature, but not neonatal, cochlear supporting cells in hair cell regeneration studies. Sci Reports 5:11621, 2015. PMCID: PMC4479870

Walters Bradley J, Zuo J. A Sox10-rtTA mouse line for inducible gene expression and fate mapping within the inner ear. J Assoc Res Otolaryngol (JARO) Jun;16(3):331-45, 2015. doi: 10.1007/s10162-015-0517-9. Epub 2015 Apr 21. PMCID: PMC4417091. 

Wang T, Chai R, Kim GS, Pham N, Jansson L, Nguyen DH, Kuo B, May L, Zuo J, Cunningham LL, Cheng AG. Damage-recruited Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in neonatal mouse utricle. Nat Communications Apr 7;6:6613, 2015. doi: 10.1038/ncomms7613. PMCID: PMC4391285.

Xu H, Robinson GW, Huang J, Lim JYS, Zhang H, Bass JK, Broniscer A, Chintagumpala M, Bartels U, Gururangan S, Hassall T, Fisher M, Cohn R, Yamashita T, Teitz T, Zuo J, Onar-Thomas A, Gajjar A, Stewart CF, Yang JJ. Common variants in ACYP2 influence the susceptibility to cisplatin-induced hearing loss. Nat Genetics Mar;47(3):263-6, 2015. doi: 10.1038/ng.3217. Epub 2015 Feb 9. PMID: 25814313

Cox BC, Dearman JA, Brancheck J, Zindy F, Roussel MF, Zuo J. Generation of Atoh1-rtTA transgenic mice to alter gene expression in hair cells of the inner ear. Sci Reports 4: 6885, 2014.

Mellado Lagarde MM, Wan G, Zhang L, Gigliello AR, McInnis JJ, Zhang Y, Bergles DE, Zuo J*, Corfas G*. Spontaneous regeneration of cochlear supporting cells after neonatal ablation ensures hearing in the adult mouse. PNAS Early Edition Nov 10, 2014. *Co-corresponding authors.

Walters Bradley J, Liu Z, Crabtree M, Coak E, Cox BC, Zuo J. Auditory hair cell-specific p27Kip1 deletion in postnatal mice promotes cell autonomous generation of new hair cells and normal hearing. J Neurosci 34(47):15751-63, 2014.

Cox BC, Chai R, LeNoir A, Liu Z, Zhang L, Chalasani K, Steigelman KA, Fang J, Rubel E, Cheng AG, Zuo J. Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo. Development 141(4):816-29, 2014.

Liu Z, Fang J, Dearman J, Zhang L, Zuo J. In vivo generation of inner hair cells in postnatal mouse cochleae by ectopic Atoh1 expression. PLoS One 9(2):e89377, 2014.

Walters BJ, Lin W, Diao S, Brimble M, Iconaru L, Dearman J, Goktug A, Chen T, Zuo J. High-throughput screening reveals Alsterpaullone, 2-Cyanoethyl as a potent p27Kip1 transcriptional inhibitor. PLoS One 9(3):e91173, 2014.

Layman WS, Sauceda MA, Zuo J. Epigenetic alterations by NuRD and PRC2 in the neonatal mouse cochlea. Hearing Res 304C:167-178, 2013.

Mellado Lagarde MM, Cox BC, Fang J, Taylor R, Forge A, Zuo J. Selective ablation of pillar and Deiters’ cells severely affects cochlear postnatal development and hearing in mice. J. Neurosci 33(4):1564-76, 2013.

Liu Z, Walters BJ, Owen T, Brimble MA, Steigelman KA, Zhang L, Mellado-Lagarde MM, Valentine MB, Yu Y, Cox BC, Zuo J. Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium. J Neurosci 32(31):10530-40, 2012.

Liu Z, Owen T, Fang J, Zuo J. Overactivation of Notch1 Signaling Induces Ectopic Hair Cells in the Mouse Inner Ear in an Age-Dependent Manner. PLoS ONE 7(3):e34123, 2012.

Chai R, Kuo B, Wang T, Liaw E, Xia A, Jan T, Liu Z, Taketo M, Oghalaia J, Nussec R, Zuo J, Cheng A. Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. PNAS 109(21):8167-72, 2012.

Liu Z, Dearman JA, Cox BC, Walters BJ, Zhang L, Ayrault O, Zindy F, Gan L, Roussel MF, Zuo J. Age-dependent in vivo conversion of mouse cochlear pillar and deiters' cells to immature hair cells by atoh1 ectopic expression. J Neurosci 32(19):6600-10, 2012.

Burns JC, Cox BC, Thiede BR, Zuo J, Corwin JT. In vivo proliferative regeneration of balance hair cells in newborn mice. J Neurosci 32(19):6570-7, 2012.

Liu Z, Owen T, Fang J, Srinivasan RS, Zuo J. In vivo notch reactivation in differentiating cochlear hair cells induces sox2 and prox1 expression but does not disrupt hair cell maturation. Dev Dyn February 2, 2012.

Weddell TD, Mellado-Lagarde M, Lukashkina VA, Lukashkin AN, Zuo J, Russell IJ. Prestin links extrinsic tuning to neural excitation in the mammalian cochlea. Curr Biol 21(18):682-3, 2011.

Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Geleoc GSG, Holt JR, Zuo J. Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. J Neurosci 31(43):12241-50, 2011.

Show More

Yu Y, Weber T, Yamashita T, Liu Z, Valentine MB, Cox BC,Zuo J. In vivo proliferation of postmitotic cochlear supporting cells by acute ablation of the retinoblastoma protein in neonatal mice. J Neurosci 30(17):5927-5936, 2010.

Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao QA, Rank G, Auden A, Srivastava S, Papenfuss TA, Murdoch JN, Humbert PO, Parekh V, Boulos N, Weber T, Zuo J, Cunningham JM, Jane SM. Epidermal wound repair is regulated by the planar cell polarity signaling pathway.Developmental Cell 19(1):138-47, 2010.

Liu Z, Owen T, Zhang L, Zuo J. Dynamic expression pattern of sonic hedgehog in developing cochlear spiral ganglion neurons. Devel Dyn 239(6):1674-83, 2010.

Wu X, Steigelman K, Bonten E, Hu H, He W, Ren T, Zuo J, d’Azzo A. Vacuolization and alterations of lysosomal membrane proteins in cochlear marginal cells underlie hearing loss in Neuraminidase 1 deficient mice. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802:259-268, 2010. NIHMSID: NIHMS155345.

Yamashita T, Liu J, Gao J, LeNoue S, Wang C, Kaminoh J, Bowne SJ, Sullivan LS, Daiger SP, Zhang K, Fitzgerald ME, Kefalov V, Zuo J. Essential and synergistic roles of RP1 and RP1L1 in rod photoreceptor axoneme and retinitis pigmentosa. J Neurosci 29(31): 9748-9760, 2009. PMCID: 2748320.

Mellado Lagarde MM, Drexl M, Lukashkin AN, Zuo J, Russell IJ.  Prestin’s role in cochlear frequency tuning and transmission of mechanical responses to neural excitation.Current Biology 18:200-202, 2008.

Dallos P, Wu X, Cheatham MA, Gao J, Zheng J, Anderson CT, Jia S, Wang X, Cheng WHY, Sengupta S, He DZZ, Zuo J. Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron 58(3): 333-339, 2008.

Weber T, Corbett MK, Chow LML, Valentine MB, Baker SJ,Zuo J. Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells. Proc Natl Acad Sci USA 105(2):781-5, 2008.

Maison SF, Parker LL, Young L, Adelman JP, Zuo J, Liberman MC Overexpression of SK2 channels enhances efferent suppression of cochlear responses without enhancing noise resistance. J Neurophysiol 97(4):2930-6, 2007.

Gao J, Maison SF, Wu X, Hirose K, Jones SM, Bayazitov I, Tian Y, Mittleman G, Matthews D, Zakharenko S, Liberman MC, Zuo J. Orphan glutamate receptor d1 subunit required for high-frequency hearing. Mol Cell Biol 27(12):4500–12, 2007.

Gao J, Wang X, Wu X, Aguinaga S, Huynh K, Jia S, Matsuda K, Patel M, Zheng J, Cheatham M, He D, Dallos P, Zuo J. Prestin-based outer hair cell somatic motility in knockin mice does not appear to adjust the operating point of a cilia-based amplifier. Proc Natl Acad Sci USA104(30):12542-12547, 2007.

Habiby Kermany M, Parker LL, Guo YK, Miller D, Swanson D, Yoo TJ, Goldowitz D, Zuo J. Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen. Hearing Res 220(1-2):76-86, 2006.

Liu J, Huang Q, Higdon J, Liu W, Tao X, Yamashita T, Cheon K, Cheng C, Zuo J. Distinct gene expression profiles and reduced JNK signaling in retinitis pigmentosa caused by RP1 mutations. Hum Mol Genet 14(19): 2945-2958, 2005.

Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, Li T. Elestic fiber homeostasis requires lysyl oxidase-like 1. Nature Genet 36:178-182, 2004.

Last update: August 2016