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Eric J. Enemark, PhD
Eric J. Enemark, PhD

Eric J. Enemark, PhD

Associate Member, St. Jude Faculty



BA – Carleton College, Northfield, MN (1991)
PhD – Stanford University, Stanford, CA (1999)

Research Interests

Molecular mechanisms of DNA replication:

  • Atomic details underlying molecular recognition and site-specific DNA-binding
  • Molecular details of DNA manipulation and translocation
  • The role of ATPases and their chemical architecture 

Selected Publications

M. Meagher*, L. B. Epling*, E. J. Enemark, “DNA translocation mechanism of the MCM complex and implications for replication initiation”, Nat Commun doi: 10.1038/s41467-019-11074-3. 2019.

Epling LB*, Grace CR*, Lowe BR*, Partridge JF#, Enemark EJ#. Cancer-associated mutants of RNA helicase DDX3X are defective in RNA binding and translation. JMB 427:1779-96, 2015. Featured article, selected for cover illustration.

Froelich CA, Nourse A, Enemark EJ. MCM ring hexamerization is a prerequisite for DNA-binding. NAR 43:9553–9563, 2015.

Miller JM, Enemark EJ. Archaeal MCM Proteins as an Analog for the Eukaryotic Mcm2–7 Helicase to Reveal Essential Features of Structure and Function. Archaea 305497, 2015.

Miller JM*, Arachea BT*, Epling LB, Enemark EJ. Analysis of the crystal structure of an active MCM hexamer. Elife 3:e03433, 2014.

Froelich CA*, Kang S*, Epling LB, Bell SP#, Enemark EJ#, .A conserved MCM single-stranded DNA binding element is essential for replication initiation. Elife 3:e01993, 2014.

Lee SJ, Syed S, Enemark EJ, Schuck S, Stenlund A, Ha T, Joshua-Tor L. Dynamic look at DNA unwinding by a replicative helicase. Proc Natl Acad Sci U S A 111:E827-835, 2014.

Baker SD, Zimmerman EI, Wang YD, Orwick S, Zatechka DS, Buaboonnam J, Neale GA, Olsen SR, Enemark EJ, Shurtleff S, Rubnitz JE, Mullighan CG, Inaba H.  Emergence of polyclonal FLT3 tyrosine kinase domain mutations during sequential therapy with sorafenib and sunitinib in FLT3-ITD-positive acute myeloid leukemia. Clin Cancer Res 19:5758-5768, 2013.

Enemark EJ, Joshua-Tor L. Helicases and other Molecular Motors. Current Opinion in Structural Biology 18:243-257, 2008.

Enemark EJ, L. Joshua-Tor L. Mechanism of DNA translocation in a replicative hexameric helicase. Nature 442:270-275, 2006.

Tolia NH, Enemark EJ, Sim BKL, Joshua-Tor L. Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum. Cell 122:183-193, 2005.

Enemark EJ, Stenlund A, Joshua-Tor L. Crystal Structures of Two Intermediates in the Assembly of the Papillomavirus Replication Initiation Complex. EMBOJ 21:1487-1496, 2002.

Enemark EJ, Chen G, Vaughn DE, Stenlund A, Joshua-Tor L. Crystal Structure of the DNA Binding Domain of the Replication Initiation Protein E1 from Papillomavirus. Molec Cell 6:149-158, 2000.

Enemark EJ, Stack TDP. Stereospecificity and Self-Selectivity in the Generation of a Chiral Molecular Tetrahedron by Metal-Assisted Self-Assembly. Angew Chem Int Ed Engl 37:932-935, 1998.

Masood MA, Enemark EJ, Stack TDP. Ligand Self-Recognition in the Self-Assembly of a [{Cu(L)}2]2 Complex: The Role of Chirality. Angew Chem Int Ed Engl 37:928-932, 1998.

Enemark EJ, Stack TDP. Spectral and Structural Characterization of Two Ferric Coordination Modes of a Simple Bis(catecholamide) Ligand: Metal-Assisted Self-Assembly in a Siderophore Analog. Inorganic Chemistry 35:2719-2720, 1996.

Enemark EJ, Stack TDP. Synthesis and Structural Characterization of a Stereospecific Dinuclear Gallium Triple Helix: Use of the trans-Influence in Metal-Assisted Self-Assembly. Angew Chem Int Ed Engl 34:996-998, 1995.

Last update: September 2019