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Jeremie H. Estepp, MD
Jeremie H. Estepp, MD

Jeremie H. Estepp, MD

Associate Member, St. Jude Faculty

Departments

Education

BA – Carson-Newman College, Jefferson City, Tennessee
MD – Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia
Internship/Residency – University of Tennessee, Le Bonheur Children’s Hospital
Fellowship (Pediatric Hematology/Oncology) – St. Jude Children’s Research Hospital

Research Interests

  • Thrombosis
  • Bleeding disorders
  • Sickle Cell Disease 

Selected Publications

Rampersaud E, Kang G, Palmer LE, Rashkin SR, Wang S, Bi W, Alberts NM, Anghelescu D, Barton M, Birch K, Boulos N, Brandow AM, Brooke RJ, Chang TC, Chen W, Cheng Y, Ding J, Easton J, Hodges JR, Kanne CK, Levy S, Mulder H, Patel AP, Puri L, Rosencrance C, Rusch M, Sapkota Y, Sioson E, Sharma A, Tang X, Thrasher A, Wang W, Yao Y, Yasui Y, Yergeau D, Hankins JS, Sheehan VA, Downing JR, Estepp JH, Zhang J, DeBaun M, Wu G, Weiss MJ. A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease. Blood Adv Jul 27;5(14):2839-2851, 2021. doi: 10.1182/bloodadvances.2021004634.

Rashkin SR, Rampersaud E, Kang G, Ataga KI, Hankins JS, Wang W, Estepp JH, Weiss MJ, Lebensburger J, Zahr RS. Generalization of a genetic risk score for time to first albuminuria in children with sickle cell anaemia: SCCRIP cohort study results. Br J Haematol Jul;194(2):469-473, 2021. doi: 10.1111/bjh.17647. Epub Jun 16, 2021.

Estepp JH, Cong Z, Agodoa I, Kang G, Ding J, McCarville MB, Hankins JS, Wang WC. What drives transcranial Doppler velocity improvement in paediatric sickle cell anaemia: Analysis from the Sickle Cell Clinical Research and Intervention Program (SCCRIP) longitudinal cohort study. Br J Haematol Jul;194(2):463-468, 2021. doi: 10.1111/bjh.17620. Epub Jun 15, 2021.

Sapkota Y, Qin N, Ehrhardt MJ, Wang Z, Chen Y, Wilson CL, Estepp J, Rai P, Hankins JS, Burridge PW, Jefferies JL, Zhang J, Hudson MM, Robison LL, Armstrong GT, Mulrooney DA, Yasui Y. Genetic variants associated with therapy-related cardiomyopathy among childhood cancer survivors of African ancestry. Cancer Res May 1;81(9):2556-2565, 2021. doi: 10.1158/0008-5472.CAN-20-2675. Epub Dec 7, 2020.

Maroda AJ, Spence MN, Larson SR, Estepp JH, Gillespie MB, Harris AJ, Mamidala MP, Sheyn AM. Screening for obstructive sleep apnea in children with sickle cell disease: A pilot study. Laryngoscope Mar;131(3):E1022-E1028. 2021. doi: 10.1002/lary.29036. Epub Aug 20, 2020.

Lebensburger JD, Gossett J, Zahr R, Wang WC, Ataga KI, Estepp JH, Kang G, Hankins JS. High bias and low precision for estimated versus measured glomerular filtration rate in pediatric sickle cell anemia. Haematologica  Jan 1;106(1):295-298, 2021. doi: 10.3324/haematol.2019.242156.

Sun LR, Linds A, Sharma M, Rafay M, Vadivelu S, Lee S, Brandão LR, Appavu B, Estepp JH, Hukin J, Hassanein SMA, Chan A, Beslow LA. Cancer and Tumor-Associated Childhood Stroke: Results From the International Pediatric Stroke Study. Pediatr Neurol Oct;111:59-65, 2020. doi: 10.1016/j.pediatrneurol.2020.06.002. Epub Jun 10, 2020. 

Alberts NM, Badawy SM, Hodges J, Estepp JH, Nwosu C, Khan H, Smeltzer MP, Homayouni R, Norell S, Klesges L, Porter JS, Hankins JS. Development of the InCharge Health Mobile App to Improve Adherence to Hydroxyurea in Patients With Sickle Cell Disease: User-Centered Design Approach. JMIR Mhealth Uhealth May 8;8(5):e14884, 2020. doi: 10.2196/14884.

Zahr RS; Hankins JS, Kang G, Li C, Wang WC, Lebensburger J, Estepp JH. Hydroxyurea prevents onset and progression of albuminuria in children with sickle cell anemia. Am J Hematol Jan;94(1):E27-E29, 2019. doi: 10.1002/ajh.25329. Epub Nov 29, 2018.

El-Gohary Y, Fleming A, Zhang H, Estepp JH, Hankins JS, Wang W, Davidoff AM, Murphy AJ. Acute chest syndrome after splenectomy in children with sickle cell disease. J Surg Res Oct;242:336-341, 2019. doi: 10.1016/j.jss.2019.04.077. 2019 May 23, 2019.

Zahr RS, Rampersaud E, Kang G, Weiss MJ, Wu G, Davis RL, Hankins JS, Estepp JH, Lebensburger J. Children with sickle cell anemia and APOL1 genetic variants develop albuminuria early in life. Haematologica  Sep;104(9):e385-e387, 2019. doi: 10.3324/haematol.2018.212779. Epub Mar 19, 2019.

Claassen D, Boals M, Bowling KM, Cooper GM, Cox J, Hershfield M, Lewis S, Wlodarski M, Weiss MJ, Estepp JH. Complexities of genetic diagnosis illustrated by an atypical case of congenital hypoplastic anemia. Cold Spring Harb Mol Case Stud Dec 17;4(6), 2018. pii: a003384. doi: 10.1101/mcs.a003384.

Mesleh Shayeb A, Smeltzer MP, Kaste SC, Brown A, Estepp JH, Nottage KA. Vaso-occlusive crisis as a predictor of symptomatic avascular necrosis in children with sickle cell disease. Pediatr Blood Cancer Sept. 5;e27435, 2018.

Hankins JS, Estepp JH, Hodges JR, Villavicencio MA, Robison LL, Weiss MJ, Kang G, Schreiber JE, Porter JS, Kaste SC, Saving KL, Bryant PC, Deyo JE, Nottage KA, King AA, Brandow AM, Lebensburger JD, Adesina O, Chou ST, Zemel BS, Smeltzer MP, Wang WC, Gurney JG. Sickle Cell Clinical Research and Intervention Program (SCCRIP): A lifespan cohort study for sickle cell disease progression from the pediatric stage into adulthood. Pediatr Blood Cancer May 24;e27228, 2018.

Estepp JH. Voxelotor (GBT440), a first-in-class hemoglobin oxygen-affinity modulator, has promising and reassuring preclinical and clinical data. Am J Hematol Mar;93(3):326-329, 2018. doi: 10.1002/ajh.25042.

Estepp JH, Smeltzer MP, Kang G, Li C, Wang WC, Abrams C, Aygun B, Ware RE, Nottage K, Hankins JS. A clinically meaningful fetal hemoglobin threshold for children with sickle cell anemia during hydroxyurea therapy. Am J Hematol Dec;92(12):1333-1339, 2017. doi: 10.1002/ajh.24906. Epub 2017 Sep 28, 2017.

Cancio MI, Aygun B, Chui DHK, Rothman JA, Scott JP, Estepp JH, Hankins JS. The clinical severity of hemoglobin S/Black (A γδβ)0 -thalassemia. Pediatr Blood Cancer Apr 28; 64:11, 2017. 

Gammal RS, Crews KR, Haidar CE, Hoffman JM, Baker DK, Barker PJ, Estepp JH, Pei D, Broeckel U, Wang W, Weiss MJ, Relling MV, Hankins J. Pharmacogenetics for safe codeine use in sickle cell disease.  Pediatrics Jul;138(1):e20153479, 2016. doi: 10.1542/peds.2015-3479.

Estepp JH, Melloni C, Thornburg CD, Wiczling P, Rogers Z, Rothman JA, Green NS, Liem R, Brandow AM, Crary SE, Howard TH, Morris MH, Lewandowski A, Garg U, Jusko WJ, Neville KA. Pharmacokinetics and bioequivalence of a liquid formulation of hydroxyurea in children with sickle cell anemia. J Clin Pharmacol Mar;56(3):298-306, 2016. doi: 10.1002/jcph.598. Epub Oct 15, 2015.

Estepp JH, Winter B, Johnson M, Smeltzer MP, Howard SC, Hankins JS. Improved hydroxyurea effect with the use of text messaging in children with sickle cell anemia. Pediatr Blood Cancer 61(11):2031-36, 2014.

Estepp JH, Smeltzer MP, Wang WC, Hoehn ME, Hankins JS, Aygun B. Protection from sickle cell retinopathy is associated with elevated HbF levels and hydroxycarbamide use in children. Br J Haematol 161(3):402-405, 2013.

Last update: July 2021