Kevin W. Freeman, PhD
Kevin W. Freeman, PhD

Kevin W. Freeman, PhD

Assistant Member, St. Jude Faculty



PhD – Baylor College of Medicine

Research Interests

  • Role of development in neuroblastoma
  • Molecular basis of metastasis
  • Creating preclinical models of neuroblastoma 

Selected Publications

Freeman KW, Bowman BR, Zetter BR. Regenerative protein Thymosin beta 4 is a Novel Regulator of Purinergic Signaling. FASEB JMar;25(3):907-15, 2011.

Freeman KW, Banyard J. ß Thymosins: Implications for the Clinic. Future Oncology Aug;5(6):755-8, 2009. Review

Finlayson AE, Freeman KW. A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. PloS ONE Nov 18; 4(11):e7833, 2009. PMCID: PMC2774968

Acevedo VD, Gangula RD, Freeman KW, Li R, Zhang Y, Wang F, Ayala GE, Peterson LE, Ittmann M, Spencer DM. Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial to mesenchymal transition. Cancer Cell Dec; 12(6):559-7, 2007.

Winter SF, Acevedo VD, Gangula RD, Freeman KW, Spencer DM, Greenberg NM. Conditional activation of FGFR1 in the prostate epithelium induces angiogenesis with concomitant differential regulation of Ang-1 and Ang-2. Oncogene Jul 26; 26(34): 4897-907, 2007.

Freeman KW, Welm BE, Gangula RD, Rosen JM, Ittmann M, Greenberg NM, Spencer DM. Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice. Cancer Res Dec 1;63(23):8256-63, 2003.

Freeman KW, Gangula RD, Welm BE, Ozen M, Foster BA, Rosen JM, Ittmann M, Greenberg NM, Spencer DM. Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation. Cancer Res Oct 1;63(19):6237-43, 2003.

Pownall ME, Welm BE, Freeman KW, Spencer DM, Rosen JM, Isaacs HV. An inducible system for the study of FGF signalling in early amphibian development. Dev Biol Apr 1;256(1):89-99, 2003.

Welm BE, Freeman KW, Chen M, Contreras A, Spencer DM, Rosen JM. Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland. J Cell Biol May 13;157(4):703-14, 2002.

Fan L, Freeman KW, Khan T, Pham E, Spencer DM. Improved artificial death switches based on caspases and FADD. Hum Gene Ther Sep 20;10(14):2273-85, 1999.

MacCorkle RA*, Freeman KW*, Spencer DM. Synthetic activation of caspases: artificial death switches. Proc Natl Acad Sci U S A Mar 31;95(7):3655-60, 1998. *Authors contributed equally to this work

Last update: February 2013