Richard Gilbertson, MD, PhD
Richard J.  Gilbertson, MD, PhD

Richard J. Gilbertson, MD, PhD

Member, St. Jude Faculty

  • Executive Vice President
  • Scientific Director
  • Director, Division of Brain Tumor Research
  • Lillian R. Cannon Comprehensive Cancer Center Director Endowed Chair

Departments

Research Interests

The principal aim of my research is to reduce the morbidity and mortality of children with central nervous system tumors through improved understanding of tumor biology. We hope to achieve this goal by:

  • Conducting extensive genomic analyses of brain tumors to identify cancer causing genetic abnormalities.
  • Integrating studies of genetic and cell signal alterations in cancers with studies of normal progenitor cells to determine the cellular and molecular origins of tumors.
  • Translating knowledge of tumor biology into effective new cures for brain tumors through pre-clinical and early clinical trials of molecular targeted therapies.

Selected Publications

Mohankumar M, Currle DS, White E, Boulos N, Dapper J, Eden C, Nimmervoll B, Thiruvenkatam R, Connelly M, Kranenburg TA, Neale G, Olsen S, Wang Y-D, Finkelstein D, Wright K, Gupta K, Ellison DW, Onar-Thomas A, Gilbertson RJ. In vivo screen identifies ependymoma oncogenes and tumor suppressor genes. Nature Genetics (in press).

Tong Y, Marino D, Nimmervoll B, Gupta K, Wang Y-D, Finkelstein D, Dalton J, Ellison DW, Ma X, Malkin D, Gilbertson RJ. Cross-species genomics identifies TAF12, NFYC and RAD54L as novel choroid plexus carcinoma oncogenes. Cancer Cell 27:712-727, 2015.

Pajtler KW, Witt H, Sill M, Jones DTW, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz H-J, Ryzhova M, Mack S, Ramaswamy V , Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, Sluis PV, Volckmann R, Koster J, Versteeg R, Fults D, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo M-L, von Deimling A, Lichter P, Taylor MD, Gilbertson RJ, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM. Molecular Classification of Ependymal Tumors across all CNS Compartments, Histopathological Grades and Age Groups. Cancer Cell 27:728-743, 2015.

Parker M, Mohankumar KM, Punchihewa C, Weinlich R, Dalton JD, Li Y, Lee R, Tatevossian RG, Phoenix TN, Thiruvenkatam R, White E, Tang B, Orisme W, Gupta K, Rusch M, Chen X, Li X, Nagahawhatte P, Hedlund E, Finkelstein D, Wu G, Shurtleff S, Easton J, Boggs K, Yergeau D, Vadodaria B, Mulder HL, Becksford J, Gupta P, Huether R, Ma J, Song G, Gajjar A, Merchant T, Boop F, Smith AA, Ding L, Lu C, Ochoa K, Zhao D, Fulton RS, Fulton LL,. Mardis ER, Wilson RK, Downing JR, Green DR, Zhang J, Ellison DW, Gilbertson RJ. C11orf95-RELA fusions drive oncogenic NF-κB signaling in ependymoma. Nature 506(7489):451-5, 2014.

Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Beckford J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ. Novel mutations target distinct subgroups of medulloblastoma. Nature 488:43-48, 2012.

Kawauchi D, Robinson G, Uziel T, Gibson P, Rehg J, Gao C, Finkelstein D, Qu C, Pounds S, Ellison DW, Gilbertson RJ, Roussel MF. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21:168-80, 2012.

Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold A, Wright KD, Johnson RA, Poppleton H, Mohankumar KM, Feau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WKA, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. An integrated in vitro and in vivo high throughput screen identifies treatment leads for ependymoma. Cancer Cell 20:384-99, 2011.

Gilbertson RJ. Mapping Cancer Origins. Cell 145 :25-9, 2011.

Gibson P, Tong, Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang Z-J, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ. Subtypes of medulloblastoma have distinct developmental origins. Nature 468:1095-9. 2010.

Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein DF, Pounds SB, Rand V, Leary SE, White E, Eden C, Hogg T, Northcott P, Mack S, Neale G, Wang M, Coyle B, Atkinson J, DeWire M, Kranenburg TA, Gillespie Y, Allen JC, Merchant T, Boop FA, Sanford RA, Gajjar A, Ellison DW, Taylor MD, Grundy RG, Gilbertson RJ. Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature 466: 632–636, 2010.

Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ. Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature 457:603-7, 2009.

Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, Oh EY, Gaber W, Finklestein D, Allen M, Frank A, Bayazitov IT, Zakharenko SS, Gajjar A, Davidoff A, Gilbertson RJ. A Perivascular niche for brain tumor stem cells. Cancer Cell 11:69-82, 2007.

Taylor MD, Poppleton H, Fuller C, Su X, Liu Y, Jensen P, Magdelano S, Dalton J, Board J, MacDonald T, Rutka J, Guha A, Gajjar A, Curran T, Gilbertson RJ. Radial Glia cells are candidate stem cells of ependymoma. Cancer Cell 8:323-335, 2005.

Last update: May 2015