Hans Haecker, MD, PhD
Hans Haecker MD, PhD

Hans Haecker MD, PhD

Associate Member, St. Jude Faculty

Departments

Education

MD – University of Ulm, Germany (1995)
PhD – Technical University of Munich, Germany (2000)

Research Interests

  • Toll-like-receptor (TLR) signal transduction, inflammation and drug development.
  • Molecular basis of Influenza Virus Pathogen - Host interactions.
  • Experimental hematopoiesis/ myelopoiesis.
  • Myeloid cells in inflammation, immune defense and therapeutic strategies.

Selected Publications

Ippagunta SK, Gangwar R, Finkelstein D, Vogel P, Pelletier S, Gingras S, Redecke V, Häcker H. Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function. Proc Natl Acad Sci U S A 113(41): E6162-6171, 2016.

Kaewborisuth C, Zanin M, Häcker H, Webby RJ, Lekcharoensuk P. G45R mutation in the nonstructural protein 1 of A/Puerto Rico/8/1934 (H1N1) enhances viral replication independent of dsRNA-binding activity and type I interferon biology. Virol J Jul 12;13:127, 2016.

Redecke V, Chaturvedi V, Kuriakose J, Häcker H. SHARPIN controls the development of regulatory T cells. Immunology Jun;148(2):216-26, 2016.

Tawaratsumida K, Phan V, Hrincius ER, High AA, Webby R, Redecke V, Häcker H. Quantitative Proteomic Analysis of the Influenza A Virus Nonstructural Proteins NS1 and NS2 during Natural Cell Infection Identifies PACT as an NS1 Target Protein and Antiviral Host Factor. J Virol Aug 15;88(16):9038-9048, 2014.

Schwab L, Goroncy L, Palaniyandi S, Gautam S, Triantafyllopoulou A, Mocsai A, Reichardt W, Karlsson FJ, Radhakrishnan SV, Hanke K, Schmitt-Graeff A, Freudenberg M, von Loewenich FD, Wolf P, Leonhardt F, Baxan N, Pfeifer D, Schmah O, Schönle A, Martin SF, Mertelsmann R, Duyster J, Finke J, Prinz M, Henneke P, Häcker H, Hildebrandt GC, Häcker G, Zeiser R. Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance graft-versus-host disease via tissue damage. Nat Med Jun;20(6):648-54, 2014.

Redecke V, Wu R, Zhou J, Finkelstein D, Chaturvedi V, High AA, Häcker H. Hematopoietic progenitor cell lines with myeloid and lymphoid potential. Nat Methods Aug;10(8):795-803, 2013.

Häcker H, Chi L, Rehg J E, Redecke V. NF-κB-inducing kinase (NIK) prevents the development of hypereosinophilic syndrome (HES)-like disease in mice independent of IKKα activation. J Immunol May 1; 188 (9), 2012.

Zhou J, Wu R, High AA, Slaughter CA, Finkelstein D, Rehg JE, Redecke V, Häcker H. A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease. Proc Natl Acad Sci USA Nov 1;108(44):E998-1006, 2011.

Stempin CC, Chi L, Giraldo-Vela JP, High AA, Häcker H, Redecke V. The E3 ubiquitin ligase mindbomb homolog 2 (Drosophila) (MIB2) controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-{kappa}B activation. J Biol Chem Oct 28;286(43):37147-57, 2011.

Kirschnek S, Vier J, Gautam S, Frankenberg T, Rangelova S, Eitz-Ferrer P, Grespi F, Ottina E, Villunger A, Häcker H, Häcker G. Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the proapoptotic BH3-only protein Noxa. Cell Death and Differentiation Jun 10, 2011.

Garrison SP, Thornton JA, Häcker H, Webby R, Rehg JE, Parganas E, Zambetti GP, Tuomanen EI. The p53-Target Gene Puma Drives Neutrophil-Mediated Protection against Lethal Bacterial Sepsis.PLoS Pathog Dec 23;6(12):e1001240, 2010.

Woehrl B, Klein M, Rupprecht TA, Schmetzer H, Angele B, Häcker H, Häcker G, Pfister HW, Koedel U. CXCL16 contributes to neutrophil recruitment to cerebrospinal fluid in pneumococcal meningitis. J Infect Dis Nov 1; 202(9):1389-96, 2010.

Lemessurier K, Häcker H, Tuomanen E, Redecke V. Inhibition of T-cells Provides Protection Against Early Invasive Pneumococcal Disease. Infect Immun Dec; 78(12):5287-94, 2010.

Koedel U, Frankenberg T, Kirschnek S, Obermaier B, Häcker H, Paul R, Häcker G. Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. PLoS Pathog May; 5(5):e1000461, 2009.

Wang H, Matsuzawa A, Brown SA, Zhou J-R, Forbes K, Häcker H, Karin M, Vignali DAA. In vivo analysis of non-degradative protein ubiquitylation with a monoclonal antibody specific for lysine 63-linked polyubiquitin. Proc Natl Acad Sci USA Dec 23; 105 (51):20197-202, 2008.

Into T, Inomata M, Nakashima M, Shibata KI, Häcker H, Matsushita K. Regulation of MyD88-dependent signaling events by S-nitrosylation retards Toll-like receptor signal transduction and initiation of acute-phase immune responses. Mol Cell Biol Feb; 28(4):1338-47, 2008.

Wang GG, Calvo KR, Pasillas MP, Sykes DB, Häcker H, Kamps MP. Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nature Methods 3:287-293, 2006. (News and Views, Nature Methods 3:248-249, 2006.)

Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. Specificity in TLR Signaling through Distinct Effector Functions of TRAF3 and TRAF6. Nature 439(7073):204-7, Jan 12, 2006;. Epub 2005 Nov 23. (Featured article, AfCS Nature, Dec 2005; News and Views, Nature Immunology Jan 7, 2006; Leading edge/ Immunology Select, Cell 124, Jan, 2006.)

Kirschnek S, Ying S, Fischer SF, Häcker H, Villunger A, Hochrein H, Hacker G. Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein Bim. J Immunol Jan 15;174(2):671-9, 2005.

Amir RE, Häcker H, Karin M, Ciechanover A. Mechanism of processing of the NF-kappaB2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene Apr 1; 23(14):2540-7, 2004.

Redecke V, Häcker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E. Activation of TLR2 induces a Th2 immune response and promotes experimental asthma. J Immunol 172 (5), 2004.

Seegmüller I, Häcker H, Wagner H. IL-4 regulates IL-12 p40 expression post-transcriptionally as well as via a promoter-based mechanism. Eur J Immunol 33 (2):428-433, 2003.

Häcker H, Fürmann C, Wagner H, Häcker G. Caspase-9/-3 Activation and Apoptosis Are Induced in Mouse Macrophages upon Ingestion and Digestion of Escherichia coli Bacteria. J Immunol169(6):3172-9, 2002.

Ahmad-Nejad P, Häcker H, Rutz M, Bauer S, Vabulas RM, Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur J Immunol32(7):1958-68, 2002.

Bauer S, Kirschning CJ, Häcker H, Redecke V, Hausmann S, Akira S, Wagner H, Lipford GB. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 98(16):9237-42, 2001.

Häcker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H. Immune Cell Activation by Bacterial CpG-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor-Associated Factor (TRAF)6. J Exp Med 192:595-600, 2000.

Show More

Häcker H, Mischak H, Häcker G, Eser S, Prenzel N, Ullrich A, and Wagner H. Cell type-specific activation of Mitogen Activated Protein Kinases by CpG-DNA controls Interleukin-12 release from Antigen Presenting Cells. EMBO J 18:6973-6982, 1999.

Häcker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T, Heeg K, Lipford GB, and Wagner H. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J 17:6230-6240, 1998.

Heeg K, Sparwasser T, Lipford GB, Häcker H, Zimmermann S, Wagner H. Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells. Eur J Clin Microbiol Infect Dis 17, 464-469, 1998.

Sparwasser T, Miethke T, Lipford G, Erdmann A, Häcker H, Heeg K, Wagner H. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol 27, 1671-1679, 1997.

Sparwasser T, Miethke T, Lipford G, Borschert K, Häcker H, Heeg K, Wagner H. Bacterial DNA causes septic shock. Nature 386, 336-337, 1997.

del Val M, Hengel H, Häcker H, Hartlaub U, Ruppert T, Lucin P, Koszinowski UH. Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment. J Exp Med 176, 729-738, 1992.

Last update: April 2017