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Scott N. Hwang, MD, PhD
Scott N. Hwang, MD, PhD

Scott N. Hwang, MD, PhD

Assistant Member, St. Jude Faculty



MD – Temple University School of Medicine, Philadelphia, Pennsylvania 
PhD – University of Pennsylvania, Philadelphia, Pennsylvania 
MS – (Bioengineering; Electrical Engineering) University of Pennsylvania, Philadelphia, Pennsylvania 
BS – Massachusetts Institute of Technology, Cambridge, Massachusetts 
Residency/Fellowship – New York University Combined Neurology/Radiology/Neuroradiology Program

Research Interests

  • MRI and MRS of brain tumors
  • Quantitative image analysis and processing
  • Computational modeling 
  • Imaging genomics

Selected Publications

Jain R, Poisson LM, Gutman D, Scarpace L, Hwang SN, Holder CA, Wintermark M, Rao A, Colen RR, Kirby J, Freymann J, Jaffe CC, Mikkelsen T, Flanders A. Outcome prediction in patients with glioblastoma by using imaging, clinical, and genomic biomarkers: focus on the nonenhancing component of the tumor. Radiology 272(2):484-493, 2014.

Nicolasjilwan M, Hu Y, Yan C, Meerzaman D, Holder CA, Gutman D, Jain R, Colen R, Rubin DL, Zinn PO, Hwang SN, Raghavan P, Hammoud DA, Scarpace LM, Mikkelsen T, Chen J, Gevaert O, Buetow K, Freymann J, Kirby J, Flanders AE, Wintermark M. Addition of MR imaging features and genetic biomarkers strengthens glioblastoma survival prediction in TCGA patients. J Neuroradiol July 2, 2014.

Wei L, Hong S, Yoon Y, Hwang SN, Park JC, Zhang Z, Olson JJ, Hu XP, Shim H. Early prediction of response to Vorinostat in an orthotopic glioma rat model. NMR Biomed 2012 (in press).

Vincentelli C, Hwang SN, Holder CA, Brat DJ. The use of neuroimaging to guide the histologic diagnosis of central nervous system lesions. Adv Anat Pathol 19(2):97-107, 2012.

Hisham EZ, Puskas JD, Hwang S, Thourani VH, Lattouf OM, Kilgo P, Halkos ME. Avoiding the clamp during off-pump coronary artery bypass reduces cerebral embolic events: results of a prospective randomized trial. Interactive Cardiovasc Thorac Surg 14:12-16, 2012.

Puskas JD, Stringer A, Hwang SN, Hatfield B, Smith AS, Kilgo PD, Williams WH. Neurocognitive and neuroanatomic changes after off-pump versus on-pump CABG: Long-term follow-up of a randomized trial. J Thorac Cardiovasc Surg 141(5):1116-1127, 2011.

Ong HH, Wright AC, Wehrli SL, Souza A, Schwartz ED, Hwang SN, Wehrli FW. Indirect measurement of regional axon diameter in excised mouse spinal cord with q-space imaging: simulation and experimental studies. Neuroimage 40(4):1619-1632, 2008.

Chin CL, Wehrli FW, Fan Y, Hwang SN, Schwartz ED, Nissanov J, Hackney DB. Assessment of axonal fiber tract architecture in excised rat spinal cord by localized NMR q-space imaging: simulations and experimental studies. Magn Reson Med 52(4):733-740, 2004.

Hwang SN, Chin CL, Wehrli FW, Hackney DB. An imagebased finite difference model for simulating restricted diffusion. Magn Reson Med 50(2):373-382, 2003.

Chin CL, Wehrli FW, Hwang SN, Jaggard DL, Hackney DB, Wehrli SW. Feasibility of probing boundary morphology of structured materials by 2D NMR q-space imaging. J Magn Reson 160(1):20-25, 2003.

Takahashi M, Wehrli FW, Hilaire L, Zemel BS, Hwang SN. In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure. Proc Natl Acad Sci USA 99(7):4574-4579, 2002.

Schwartz ED, Chin CL, Takahashi M, Hwang SN, Hackney DB. Diffusion-weighted imaging of the spinal cord. Neuroimaging Clin N Am 12(1):125-146, 2002.

Hwang SN, Wehrli FW. Subvoxel processing: a method for reducing partial volume blurring with application to in vivo MR images of trabecular bone. Magn Reson Med 47(5):948-957, 2002.

Chin CL, Wehrli FW, Hwang SN, Takahashi M, Hackney DB. Biexponential diffusion attenuation in the rat spinal cord: computer simulations based on anatomic images of axonal architecture. Magn Reson Med 47(3):455-460, 2002.

Wehrli FW, Hwang SN, Song HK, Gomberg BR. Visualization and analysis of trabecular bone architecture in the limited spatial resolution regime of in vivo micro-MRI. Adv Exp Med Biol 496:153-164, 2001.

Wehrli FW, Gomberg BR, Saha PK, Song HK, Hwang SN, Snyder PJ. Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. J Bone Miner Res 16(8):1520-1531, 2001.

Gomberg BR, Saha PK, Song HK, Hwang SN, Wehrli FW. Three-dimensional digital topological analysis of trabecular bone. Adv Exp Med Biol 496:57-65, 2001.

Wehrli FW, Hopkins JA, Hwang SN, Song HK, Snyder PJ, Haddad JG. Cross-sectional study of osteopenia with quantitative MR imaging and bone densitometry. Radiology 217(2):527-538, 2000.

Takahashi M, Wehrli FW, Hwang SN, Wehrli SL. Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model. Magn Reson Imaging 18(1):33-39, 2000.

Gomberg BR, Saha PK, Song HK, Hwang SN, Wehrli FW. Topological analysis of trabecular bone MR images. IEEE Trans Med Imaging 19(3):166-174, 2000.

Axel L, Kolman L, Charafeddine R, Hwang SN, Stolpen AH. Origin of a signal intensity loss artifact in fat-saturation MR imaging. Radiology 217(3):911-915, 2000.

Takahashi M, Wehrli FW, Wehrli SL, Hwang SN, Lundy MW, Hartke J, Borah B. Effect of prostaglandin and bisphosphonate on cancellous bone volume and structure in the ovariectomized rat studied by quantitative threedimensional nuclear magnetic resonance microscopy. J Bone Miner Res 14(5):680-689, 1999.

Hwang SN, Wehrli FW. Experimental evaluation of a surface charge method for computing the induced magnetic field in trabecular bone. J Magn Reson 139(1):35-45, 1999.

Wehrli FW, Hwang SN, Song HK. New architectural parameters derived from micro-MRI for the prediction of trabecular bone strength. Technol Health Care 6(5-6):307-320, 1998.

Wehrli FW, Hwang SN, Ma J, Song HK, Ford JC, Haddad JG. Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing. Radiology 206(2):347-357, 1998.

Ma J, Wehrli FW, Song HK, Hwang SN. A single-scan imaging technique for measurement of the relative concentrations of fat and water protons and their transverse relaxation times. J Magn Reson125(1):92-101, 1997.

Hwang SN, Wehrli FW, Williams JL. Probability-based structural parameters from three-dimensional nuclear magnetic resonance images as predictors of trabecular bone strength. Med Phys 24(8):1255-1261, 1997.

Chung HW, Hwang SN, Yeung HN, Wehrli FW. Mapping of the magnetic-field distribution in cancellous bone. J Magn Reson B 113(2):172-176, 1996.

Hwang SN, Wehrli FW. The calculation of the susceptibility-induced magnetic field from 3D NMR images with applications to trabecular bone. J Magn Reson B 109:126-145, 1995.

Last update: September 2014