Chimene Kesserwan, MD
Chimene Kesserwan, MD

Chimene Kesserwan, MD

Assistant Member, St. Jude Faculty

Departments

Divisions

Education

MD – Lebanese University, Faculty of Medical Sciences, Lebanon
Pediatric Residency – The American University of Beirut Medical Center
Anatomic Pathology Residency – The University of Oklahoma Health Sciences Center
Clinical Genetics Residency
 – The National Human Genome Research Institute (NHGRI)
Pediatrics Hematology-Oncology Fellowship – Johns Hopkins University and the National Cancer Institute 

Research Interests

  • Familial-based studies using genome approaches to identify new rare cancer-predisposing genes
  • Sequence variant classification and interpretation

Selected Publications

Wang Z, Wilson CL, Easton J, Thrasher A, Mulder H, Liu Q, Hedges DJ, Wang S, Rusch MC, Edmonson MN, Levy S, Lanctot JQ, Caron E, Shelton K, Currie K, Lear M,  Patel A, Rosencrance C, Shao Y, Vadodaria B, Yergeau D, Sapkota Y, Brooke RJ, Moon W, Rampersaud E, Ma X, Chang TC, Rice SV, Pepper C, Zhou X, Chen X, Chen W, Jones A, Boone B, Ehrhardt MJ, Krasin MJ, Howell RM, Phillips NS, Lewis C, Srivastava D, Pui CH, Kesserwan CA, Wu G, Nichols KE, Downing JR, Hudson MM, Yasui Y, Robison LL, Zhang J. Genetic Risk for Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer. J Clin Oncol Jul 10;36(20):2078-2087, 2018. doi: 10.1200/JCO.2018.77.8589. Epub 2018 May 30. PubMed PMID: 29847298; PubMed Central PMCID: PMC6036620.

Schwartz JR, Ma J, Lamprecht T, Walsh M, Wang S, Bryant V, Song G, Wu G, Easton J, Kesserwan C, Nichols KE, Mullighan CG, Ribeiro RC, Klco JM. The genomic landscape of pediatric myelodysplastic syndromes. Nat Commun Nov 16;8(1):1557, 2017. doi: 10.1038/s41467-017-01590-5. PubMed PMID: 29146900; PubMed Central PMCID: PMC5691144.

Schwartz JR, Wang S, Ma J, Lamprecht T, Walsh M, Song G, Raimondi SC, Wu G, Walsh MF, McGee RB, Kesserwan C, Nichols KE, Cauff BE, Ribeiro RC, Wlodarski M, Klco JM. Germline SAMD9 mutation in siblings with monosomy 7 and myelodysplastic  syndrome. Leukemia Aug;31(8):1827-1830, 2017. doi: 10.1038/leu.2017.142. Epub 2017 May 10. PubMed PMID: 28487541; PubMed Central PMCID: PMC5540771.

Johnson LM, Valdez JM, Quinn EA, Sykes AD, McGee RB, Nuccio R, Hines-Dowell SJ, Baker JN, Kesserwan C, Nichols KE, Mandrell BN. Integrating next-generation sequencing into pediatric oncology practice: An assessment of physician confidence and understanding of clinical genomics. Cancer Jun 15;123(12):2352-2359, 2017. doi: 10.1002/cncr.30581. Epub 2017 Feb 13. PubMed PMID: 28192596; PubMed Central PMCID: PMC5710798.

Valdez JM, Nichols KE, Kesserwan C. Li-Fraumeni syndrome: a paradigm for the understanding of hereditary cancer predisposition. Br J Haematol Feb;176(4):539-552, 2017. doi: 10.1111/bjh.14461. Epub 2016 Dec 16. Review. PubMed PMID: 27984644.

Kesserwan C, Friedman Ross L, Bradbury AR, Nichols K. The Advantages and Challenges of Testing Children for Heritable Predisposition to Cancer. Am Soc Clin Oncol Educ Book 35:251-69, 2016.

Candotti F, Shaw KL, Muul L, Carbonaro D, Sokolic R, Choi C, Schurman SH, Garabedian E, Kesserwan C, Jagadeesh GJ, Fu PY, Gschweng E, Cooper A, Tisdale JF, Weinberg KI, Crooks GM, Kapoor N, Shah A, Abdel-Azim H, Yu XJ, Smogorzewska M, Wayne AS, Rosenblatt HM, Davis CM, Hanson C, Rishi RG, Wang X, Gjertson D, Yang OO, Balamurugan A, Bauer G, Ireland JA, Engel BC, Podsakoff GM, Hershfield MS, Blaese RM, Parkman R, Kohn DB. Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Blood Nov 1;120(18):3635-46, 2012.

Kesserwan C, Sokolic R, Cowen EW, Garabedian E, Heselmeyer-Haddad K, Lee CC, Pittaluga S, Ortiz C, Baird K, Lopez-Terrada D, Bridge J, Wayne AS, Candotti F. Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase-deficient severe combined immune deficiency. J Allergy Clin Immunol Mar;129(3):762-769, 2012.

Muchel A, Kesserwan C, Symons HJ, Luznik L, Kasamon YL, Jones RJ, Fuchs EJ. Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide. Pediatr Rep Jun 22;3 Suppl 2:e15, 2011..

Sokolic R, Maric I, Kesserwan C, Garabedian E, Hanson IC, Dodds M, Buckley R, Issekutz AC, Kamani N, Shaw K, Tan B, Bali P, Hershfield MS, Kohn DB, Wayne AS, Candotti F. Myeloid dysplasia and bone marrow hypocellularity in adenosine deaminase-deficient severe combined immune deficiency. Blood Sep 8;118(10):2688-94, 2011.

Sokolic R, Kesserwan C, Candotti F.Recent advances in gene therapy for severe congenital immunodeficiency diseases. Curr Opin Hematol Jul;15(4):375-80, 2008.

Linardic CM, Naini S, Herndon JE 2nd, Kesserwan C, Qualman SJ, Counter CM. The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence. Cancer Res Jul 15;67(14):6691-9, 2007.

Kesserwan C, Boué DR, Kahwash SB. Isolated juvenile xanthogranuloma in the bone marrow: report of a case and review of the literature. Pediatr Dev Pathol Mar-Apr;10(2):161-4, 2007. 

Last update: July 2018