Malia B. Potts, PhD
Malia B. Potts, PhD

Malia B. Potts, PhD

Assistant Member, St. Jude Faculty

Departments

Education

PhD – University of Texas Southwestern Medical Center, Dallas, Texas
BS
 – Duke University, Durham, North Carolina

Research Interests

  • Higher-order regulation of autophagy
  • Metabolic balance between anabolic cell growth and catabolic self-renewal
  • Functional annotation of human genes and anti-cancer compounds

Selected Publications

McMillan EA, Kwon G, Clemenceau JR, Fisher KW, Vaden RM, Shaikh AF, Neilsen BK, Kelly D, Potts MB, Sung YJ, Mendiratta S, Hight SK, Lee Y, MacMillan JB, Lewis RE, Kim HS, White MA. A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery. Cell Chem Biol. 2019 Jul 31;. doi: 10.1016/j.chembiol.2019.07.008. [Epub ahead of print] PubMed PMID: 31378711.

Ling T, Lang WH, Craig J, Potts MB, Budhraja A, Opferman J, Bollinger J, Maier J, Marsico TD, Rivas F. Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models. J Nat Prod. 2019 May 14;. doi: 10.1021/acs.jnatprod.8b01087. [Epub ahead of print] PubMed PMID: 31084028.

Ling T, Maier J, Das S, Budhraja A, Bassett R, Potts MB, Shelat A, Rankovic Z, Opferman JT, Rivas F. Identification of substituted 5-membered heterocyclic compounds as potential anti-leukemic agents. Eur J Med Chem. 2019 Feb 15;164:391-398. doi: 10.1016/j.ejmech.2018.12.059. Epub 2018 Dec 24. PubMed PMID: 30611980.

Vaden RM, Oswald NW, Potts MB, MacMillan JB, White MA. FUSION-Guided Hypothesis Development Leads to the Identification of N⁶,N⁶-Dimethyladenosine, a Marine-Derived AKT Pathway Inhibitor. Mar Drugs. 2017 Mar 15;15(3). doi: 10.3390/md15030075. PubMed PMID: 28294973; PubMed Central PMCID: PMC5367032.

Piala AT, Akella R, Potts MB, Dudics-Giagnocavo SA, He H, Wei S, White MA, Posner BA, Goldsmith EJ. Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3923-7. doi: 10.1016/j.bmcl.2016.07.016. Epub 2016 Jul 6. PubMed PMID: 27426302.

Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, Purinton S, Wang Y, Ivan C, Kim HS, Borkowski RJ, Khan S, Rodriguez-Aguayo C, Lopez-Berestein G, Lea J, Gazdar A, Baggerly KA, Sood AK, White MA. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Mol Syst Biol. 2015 Dec 11;11(12):842. doi: 10.15252/msb.20156308. PubMed PMID: 26655797; PubMed Central PMCID: PMC4704493.

Potts MB, McMillan EA, Rosales TI, Kim HS, Ou YH, Toombs JE, Brekken RA, Minden MD, MacMillan JB, White MA. Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B. Nat Chem Biol. 2015 Jun;11(6):401-8. doi: 10.1038/nchembio.1797. Epub 2015 Apr 13. PubMed PMID: 25867045; PubMed Central PMCID: PMC4433765.

Pineda CT, Ramanathan S, Fon Tacer K, Weon JL, Potts MB, Ou YH, White MA, Potts PR. Degradation of AMPK by a cancer-specific ubiquitin ligase. Cell. 2015 Feb 12;160(4):715-728. doi: 10.1016/j.cell.2015.01.034. PubMed PMID: 25679763; PubMed Central PMCID: PMC5629913.

Potts MB, Kim HS, Fisher KW, Hu Y, Carrasco YP, Bulut GB, Ou YH, Herrera-Herrera ML, Cubillos F, Mendiratta S, Xiao G, Hofree M, Ideker T, Xie Y, Huang LJ, Lewis RE, MacMillan JB, White MA. Using functional signature ontology (FUSION) to identify mechanisms of action for natural products. Sci Signal. 2013 Oct 15;6(297):ra90. doi: 10.1126/scisignal.2004657. PubMed PMID: 24129700; PubMed Central PMCID: PMC4075427.

Hu Y, Potts MB, Colosimo D, Herrera-Herrera ML, Legako AG, Yousufuddin M, White MA, MacMillan JB. Discoipyrroles A-D: isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis. J Am Chem Soc. 2013 Sep 11;135(36):13387-92. doi: 10.1021/ja403412y. Epub 2013 Aug 28. PubMed PMID: 23984625; PubMed Central PMCID: PMC3845659.

Potts MB, Cameron S. Cell lineage and cell death: Caenorhabditis elegans and cancer research. Nat Rev Cancer. 2011 Jan;11(1):50-8. doi: 10.1038/nrc2984. Epub 2010 Dec 2. Review. PubMed PMID: 21150934.

Potts MB, Wang DP, Cameron S. Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1. Dev Biol. 2009 May 15;329(2):374-85. doi: 10.1016/j.ydbio.2009.02.022. Epub 2009 Feb 28. PubMed PMID: 19254707.

Liu H, Strauss TJ, Potts MB, Cameron S. Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1. Development. 2006 Feb;133(4):641-50. doi: 10.1242/dev.02234. Epub 2006 Jan 18. PubMed PMID: 16421192.

Potts MB, Vaughn AE, McDonough H, Patterson C, Deshmukh M. Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP. J Cell Biol. 2005 Dec 19;171(6):925-30. doi: 10.1083/jcb.200504082. Epub 2005 Dec 12. PubMed PMID: 16344307; PubMed Central PMCID: PMC2171313.

Deming PB, Schafer ZT, Tashker JS, Potts MB, Deshmukh M, Kornbluth S. Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. Mol Cell Biol. 2004 Dec;24(23):10289-99. doi: 10.1128/MCB.24.23.10289-10299.2004. PubMed PMID: 15542838; PubMed Central PMCID: PMC529043.

Last update: October 2019