P. Ryan Potts, PhD
Ryan Potts, PhD

Ryan Potts, PhD

Associate Member, St. Jude Faculty



BS - University of North Carolina at Chapel Hill
PhD - UT Southwestern Medical Center

Research Interests

  • Investigate the tumorigenic function and therapeutic targeting of cancer-testis antigens, including the MAGE protein family
  • Biochemical and molecular characterization of MAGE protein function in various cellular processes, including ubiquitination, endosomal trafficking and RNA stability
  • Physiological function of MAGE proteins in vivo using knockout animal models

Selected Publications

Yang SW, Li L, Connelly JP, Porter SN, Kodali K, Gan H, Park JM, Tacer KF, Tillman H, Peng J, Pruett-Miller SM, Li W, Potts PR. A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex. Mol Cell.  Jan 8, 2020. pii: S1097-2765(19)30952-9. doi: 10.1016/j.molcel.2019.12.022. [Epub ahead of print]

Ravichandran R, Kodali K, Peng J, Potts PR. Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability. EMBO Rep.  20(7):e47352. 2019 doi: 10.15252/embr.201847352. Epub  May 24 2019.

Fon Tacer K, Montoya MC, Oatley MJ, Lord T, Oatley JM, Klein J, Ravichandran R, Tillman H, Kim M, Connelly JP, Pruett-Miller SM, Bookout AL, Binshtock E, Kamiński MM, Potts PR. MAGE cancer-testis antigens protect the mammalian germline under environmental stress. Sci Adv. 2019 May 29;5(5):eaav4832. 2019 doi: 10.1126/sciadv.aav4832. eCollection May 2019.

Weon JL, Yang SW, Potts PR. Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase. Mol Cell. 4;69(1):113-125.e6; Jan 2018. doi: 10.1016/j.molcel.2017.11.010. Epub Dec 7, 2017.

Hao YH, Fountain Jr MD, Fon Tacer K, Bi W, Kang SL, Patel A, Rosenfeld JA, Le Caignec C, Isidor B, Krantz ID, Noon SE, Pfotenhauer JP, Morgan TM, Moran R, Pedersen RC, Saenz MS, Schaaf CP, Potts PR. USP7 haploinsufficiency causes a neurodevelopmental disorder due to defects in endosomal trafficking. Mol Cell 59:956-69, 2015.

Weon JL, Potts PR. The MAGE protein family and cancer. Curr Opin Cell Biol 37:1-8, 2015.

Pineda CT, Potts PR. Oncogenic MAGEA-TRIM28 ubiquitin ligase downregulates autophagy by ubiquitinating and degrading AMPK in cancer. Autophagy 11:844-6, 2015.

Pineda CT, Ramanathan S, Fon Tacer K, Weon JL, Potts MB, Ou YH, White MA, Potts PR. Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase. Cell 160:715-28, 2015. Science Signaling Editor’s Choice and Current Biology Dispatch Highlight

Hao YH, Potts PR. Ubiquitin puts actin in its place. Molecular Cell 54:544-6, 2014.

Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ, Billadeau DD, Rosen MK, Potts PR. Regulation of Actin Polymerization and Retrograde Transport by Ubiquitination. Cell 152:1051-1064, 2013. Featured in Faculty of 1000

Wu N, Kong X, Ji Z, Zeng W, Potts PR, Yokomori K, Yu H. SCC1 sumoylation by MMS21 promotes sister chromatid recombination through counteracting Wapl. Genes Dev 26:1473-85, 2012.

Ellis B, Potts PR, Porteus MH. Creating higher titer lentivirus using caffeine. Human Gene Therapy 22:93-100, 2011.

Doyle JM, Gao J, Wang J, Yang M, Potts PR. MAGE-RING complexes comprise a family of E3 ubiquitin ligases. Molecular Cell 39:963-974, 2010. Featured in News and Views, Faculty of 1000, and 2010 Science Signaling Breakthrough of the Year

Potts PR. The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination. DNA Repair 8:499-506, 2009.

Potts PR, Yu H. Chromosome Formation. Wiley Ency Chem Biol 2008. DOI:10.1002/9780470048672.wecb650

Potts PR, Yu H. The SMC5/6 Complex Maintains Telomere Length in ALT Cancer Cells through Sumoylation of Telomere-Binding Proteins. Nat Struct Mol Biol 14:581-590, 2007. Featured News and Views article and as the cover article P. Ryan Potts CV – 01/12/16

Potts PR, Porteus MH, Yu H. Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. EMBO J 25:3377-3388, 2006.

Potts PR, Yu H. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Mol Cell Biol 25:7021-7032, 2005.

Wright, K.M., Linhoff, M.W., Potts PR, Deshmukh M. Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis. J Cell Biol 167:303-313, 2004.

Olteanu A, Patel CN, Dedmon MM, Kennedy S, Linhoff MW, Minder CM, Potts PR, Deshmukh M, Pielak GJ. Stability and apoptotic activity of recombinant human cytochrome c. Biochem Biophys Res Commun 312:733-740, 2003.

Potts PR, Singh S, Knezek M, Thompson CB, Deshmukh M. Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J Cell Biol 163:789-799, 2003. Featured in News Section and in Faculty of 1000

Last update: February 2020

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