Susana C. Raimondi, PhD
Susana C. Raimondi, PhD

Susana C. Raimondi, PhD

Member, St. Jude Faculty

  • Director, Cytogenetics Laboratory

Departments

Education

PhD – University of Tennessee Center for the Health Sciences, Memphis

Research Interests

  • The cytogenetics of the leukemias and lymphomas in relation to: diagnosis, prognosis, disease course, and disease subtypes, as well as specific DNA changes and associated gene expression
  • Application of new diagnostic techniques in clinical medicine, mainly in molecular cytogenetics of neoplasias
  • Development of FISH technology to enhance our understanding of subtle/cryptic chromosomal rearrangements that escape conventional cytogenetic detection

Selected Publications

Schwartz JR, Shuoguo Wang S, Ma J, Lamprecht T, Walsh M, Song G, Raimondi SC, Wu G, Walsh MF, McGee R, Kesserwan C, Nichols K, Cauff BE, Downing JR, Ribeiro RC, Wlodarski M, Klco JM. Germline SAMD9 mutation in siblings with monosomy 7 and myelodysplastic syndrome. Leukemia May 10, 2017. doi: 10.1038/leu.2017.142. Epub ahead of print. PMID: 28487541

Tarlock K, Alonzo TA, Loken MR, Gerbing RB, Ries RE, Aplenc R, Sung L, Raimondi SC, Hirsch BA, Kahwash SB, McKenney A, Kolb EA, Gamis AS, Meshinchi S. Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group. Clin Cancer Res Jan 20, 2017. doi: 10.1158/1078-0432.CCR-16-2353. Epub ahead of print. PMID: 28108543

Vujkovic M, Attiyeh EF, Ries RE, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Wang YC, Gerbing RB, Sung L, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R. Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report. Blood Jun 8;129(23):3051-3058, 2017. doi: 10.1182/blood-2017-03-772384. PMID: 28411282

Taub JW, Berman JN, Hitzler JK, Sorrell AD, Lacayo NJ, Mast K, Head D, Raimondi S, Hirsch B, Ge Y, Gerbing RB, Wang YC, Alonzo TA, Campana D, Coustan-Smith E, Mathew P, Gamis AS. Improved outcomes or myeloid leukemia of Down syndrome: a report from the Childrens’ Oncology Group AAML0431 trial. Blood April 7 2017. Epub ahead of print. doi: 10.1182/blood-2017-01-764324. PMID: 28389462

Lamba JK, Chauhan L, Shin M, Loken M, Pollard J, Wang Y-C, Ries RE, Aplenc R, Hirsch BA, Raimondi SC, Walter RB, Bernstein ID, Gamis AS, Alonzo TA, Meshinchi S. CD33 Splicing polymorphism determines gemtuzumab ozogamicin response in de novo AML: report from randomized phase III Children’s Oncology Group Trial AAML0531. J Clin Oncol 2017 (in press). doi: 10.1200/JCO.2016.71.2513

Pui CH, Pei D, Raimondi SC, Coustan-Smith E, Jeha S, Cheng C, Bowman WP, Sandlund JT, Ribeiro RC, Rubnitz JE, Inaba H, Gruber TA, Leung WH, Yang JJ, Downing JR, Evans WE, Relling MV, Campana D. Clinical impact of minimal residual disease in children with different subtypes of acute lymphoblastic leukemia treated with response-adapted therapy. Leukemia 31(2):333-339, 2017. doi: 10.1038/leu.2016.234. PMID: 27560110, PMC5288281

Ries RE, Bolouri H, Farrar JE, Lim EL, Triche Jr TJ, Tarlock K, Auvil JG, Hirsch BA, Raimondi SC, Ma Y, Marra MA, Aplenc R, Guest EM, Kolb EA, Gamis AS, Smith MA, Gerhard DS, Meshinchi S. Alteration of chromatin modifiers and misregulation of transcription factors define the genomic profile of Infant AML. Blood 128:774, 2016.

Ramamurthy R, Hughes M, Morris V, Bolouri H, Gerbing RB, Wang YC, Loken MR, Raimondi SC, Hirsch BA, Gamis AS, Oehler VG, Alonzo TA, Meshinchi S. miR-155 expression and correlation with clinical outcome in pediatric AML: A report from Children's Oncology Group. Pediatr Blood Cancer Dec;63(12):2096-2103, 2016. doi: 10.1002/pbc.26157. Epub 2016 Aug 11. PMID: 27511899

Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi SI, Wienholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui CH, Jeha S, Harvey RC, Chen IL, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrozek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JR, Mullighan CG. Deregulation of DUX4 and ERG in acute lymphoblastic leukemia. Nature Genetics (48) 12:1481-1489, 2016. PMID 27776115. doi: 10.1038/NG.3691. PMC 5144107. NIHMS832126.

Eidenschink Brodersen L, Alonzo TA, Menssen AJ, Gerbing RB, Pardo L, Voigt AP, Kahwash SB, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Loken MR. A recurrent immunophenotype at diagnosis independently identifies high-risk pediatric acute myeloid leukemia: a report from Children's Oncology Group. Leukemia 30(10)2077-2080, 2016. doi: 10.1038/leu.2016.119. PMID 27133823. PMCID PMC5136463.

Ramamurthy R, Hughes M, Morris V, Bolouri H, Gerbing RB, Wang YC, Loken MR, Raimondi SC, Hirsch BA, Gamis AS, Oehler VG, Alonzo TA, Meshinchi S. Gemtuzumab ozogamicin reduces relapse risk in FLT3/ITD acute myeloid leukemia: A report from the Children's Oncology Group. Pediatr Blood & Cancer (63)2096-2103, 2016. doi: 10.1002/pbc.26157. PMID: 27511899

Pollard JA, Loken M, Gerbing RB, Raimondi SC, Hirsch BA, Aplenc R, Bernstein ID, Gamis AS, Alonzo TA, Meshinchi S. CD33 Expression and its association with Gemtuzumab Ozogamicin response: Results from the randomized phase III Children's Oncology Group trial AAML0531. J Clin Oncol 34(7) 747-755, 2016. PMID: 26786921 doi:10.1200/JCO.2015.62.6846

Moriyama T*, Metzger ML*, Wu G*, Nishiia R, Qian M, Devidas M, Yang W, Cheng C, Cao X, Quinn E, Raimondi S, Gastier-Foster JM, Raetz E, Larsen E, Martin PL, Bowman WP, Winick N, Komada Y, Wang S, Edmonson M, Xu H, Mardis E, Fulton R, Pui C-H, Mullighan C, Evans WE, Zhang J, Hunger SP, Relling MV, Nichols KE, Loh ML, Yang JJ. Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukemia: a systematic genetic study. Lancet Oncol 16(16):1659-1666, 2016. pii: S1470-2045(15)00369-1 doi:10.1016/S1470-2045(15)00369-1 PMID: 26522332 PMC4684709

Lamba JK, Pounds S, Cao X, Crews KR, Cogle CR, Bhise N, Raimondi SC, Downing JR, Baker SD, Ribeiro RC, Rubnitz JE. Clinical significance of in vivo cytarabine-induced gene expression signature in AML. Leukemia & Lymphoma 57(4):909-920, 2016. doi.org/10.3109/10428194.2015.1086918 PM 26366682 EM:1609201510230683

Vujkovic M, Attiyeh EF, Ries RE, Horn M, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Gerbing RB, Hirsh B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R. Concordance of copy number alterations from a common analytic pipeline for genome-wide data from the Illumina and Affymetrix genotyping platforms: A report from the Children’s Oncology Group. Cancer Genet 208(7-8) 408-413, 2015. doi: 10.1016/j.cancergen.2015.04.010 PMID: 26163103

Tarlock K, Alonzo TA, Gerbing RB, Raimondi SC, Hirsch BA, Sung L, Pollard JA, Loken M, Aplenc R, Gamis AS, Meshinchi S. Gemtuzumab Ozogamicin reduces relapse risk in FLT3/ITD+ acute myeloid leukemia: A report from The Children’s Oncology Group. Clin Cancer Res 22(8) 1951-1957, 2016. doi: 10.1158/1078-0432.CCR-15-1349. Epub 2015 Dec 7. PMID: 26644412

Mullighan CG, Jeha S, Pei D, Payne D, Coustan-Smith EC, Roberts KG, Waanders E, Choi JK, Ma X, Raimondi SC, Fan Y, Yang W, Song G, Yang JJ, Inaba H, Downing JR, Leung WH, Bowman WP Relling MV, Evans WE, Zhang J, Campana D, Pui C-H. Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels. Blood 126 (26) 2896-2899, 2015. doi: blood-2015-09-671131 PMID: 26527677

Laszlo GS, Alonzo TA, Gudgeon CJ, Harrington KH, Kentsis A, Gerbing RB, Wang YC, Ries RE, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB. High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse risk features and poor outcome in pediatric acute myeloid leukemia: A report from the Children's Oncology Group. J Hematol Oncol 8(1):115, 2015. doi: 10.1186/s13045-015-0215-4 PMID: 26487643

Andersson AK, Ma J, Wang J, Chen X, Larson-Gedman A, Dang J, Nakitandwe J, Holmfeldt L, Parker M, Easton J, Huether R, Kriwacki R, Rusch M, Wu G, Mulder H, Raimondi S, Pounds S, Guolian K, Shi L, Becksfort J, Gupta P, Payne-Turner D, Vadodaria B, Manne J, Song G, Edmonson M, Nagawatte P, Wei L, Cheng C, Pei D, Sutton R, Venn NC, Chetcuti A, Rush A, Catchpoole D, Heldrup J, Fioretos T, Lu C, Ding L, Pui C-H, Shurtleff S, Gruber TA, Mullighan CG, Mardis ER, Wilson RK, Zhang J, Downing JR. The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. Nature Genetics 47(4):330-337, 2015. doi:10.1038/ng.3230 PMID: 25730765

Inaba H, Zhou Y, Abla O, Adachi S, Auvrignon A, Beverloo HB, de Bont E, Chang T-T, Creutzig U, Dastugue N, Dworzak M, Elitzur S, Fynn A, Forestier E, Hasle H, Liang D-C, Lee V, Locatelli F, Masetti R, De Moerloose B, Reinhardt R, Rodriguez L, Shen S, Taga T, Tomizawa D, Yeoh AEJ, Zimmermann M, Raimondi SC. Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia without Down syndrome: A Retrospective International Study. Blood 126(13):1575-1584, 2015. doi: 10.1182/blood-2015-02-629204

Vujkovic M, Attiyeh EF, Ries RE, Horn M, Goodman EK, Ding Y, Kavcic M, Alonzo TA, Gerbing RB, Hirsch B, Raimondi S, Gamis AS, Meshinchi S, Aplenc R. Concordance of copy number alterations using a common analytic pipeline for genome-wide analysis of Illumina and Affymetrix genotyping data: a report from the Children's Oncology Group. See comment in PubMed Commons belowCancer Genet Jul-Aug;208(7-8):408-13, 2015. doi: 10.1016/j.cancergen.2015.04.010 PMID: 26163103 PMCID: PMC4523450

Klein K, Kaspers GJL, Harrison CJ, Beverloo HB, Reedijk A, Bongers M, Cloos J, Pession A, Reinhardt D, Zimmermann M, Creutzig U, Dworzak M, Alonzo TA, Johnston DT, Hirsch BA, Zapotocky M, De Moerloose B, Fynn A, Lee V, Taga T, Tawa A, Auvrignon A, Zeller B, Forestier E, Salgado C, Balwierz W, Popa A, Rubnitz J, Raimondi SC, Gibson B. Clinical impact of additional cytogenetic aberrations, cKIT and RAS mutations, and treatment elements in pediatric t(8;21)-AML: Results from an international retrospective study by the International Berlin-Frankfurt-Münster Study Group. J Clin Oncol 2015: 33 (36) 4247-4258, 2015. doi:10.1200/JCO.2015.61.1947

Kutny MA, Alonzo TA, Gamazon ER, Gerbing RB, Geraghty D, Lange B, Heerema NA, Sung l, Aplenc R, Franklin J, Raimondi SC, Hirsch BA, Konkashbaev A, Cox NJ, Onel K, Gamis AS, Meshinchi S. Ethnic variation of TET2 SNP rs2454206 and association with clinical outcome in childhood acute myeloid leukemia: A report from the Children’s Oncology Group. Leukemia 29(12):2424-2426, 2015. doi:10.1038/leu.2015.171 PMID: 26126966 PMCID: PMC4675677

Laszlo GS, Alonzo TA, Gudgeon CJ, Harrington KH, Gerbing RB, Wang YC, Ries RE, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB. Multimerin-1 (MMRN1) as novel adverse marker in pediatric acute myeloid leukemia: A report from the Children’s Oncology Group. Clin Cancer Res 21(14):3187-3195, 2015. doi: 10.1158/1078-0432.CCR-14-2684 PubMed # 25825478 NIHMSID 677257

Lu C, Zhang J, Nagahawatte P, Easton J, Lee S, Liu Z, Ding L, Wyczalkowski M, Valentine M, Navid F, Mulder H, Tatevossian R, Dalton J, Davenport J, Yi Z, Edmonson M, Rusch M, Wu G, Li Y, Parker M, Hedlund E, Shurtleff S, Raimondi S, Bhavin V, Donald Y, Mardis ER, Wilson RK, Evans WE, Ellison DW, Pounds S, Dyer M, Downing JR, Pappo A, Bahrami A. The genomic landscape of childhood and adolescent melanoma. J Invest Dermatol 135(3):816-23, 2015. PMID: 25268584 doi: jid2014425 [pii]10.1038/jid.2014.425

Karol SE, Coustan-Smith E, Cao X, Shurtleff SA, Raimondi SC, Choi JK, Ribeiro RC, Dahl GV, Bowman WP, Taub JW, Degar B, Leung W, Downing JR, Pui CH, Rubnitz JE, Campana D, Inaba H. Prognostic factors in children with acute myeloid leukemia and excellent response to remission induction therapy. Br J Haematol 168(1):94-101, 2015. doi: 10.1111/bjh.13107 PMID: 25164427

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Pui C-H, Pei D, Campana D, Cheng C, Sandlund JT, Bowman WP, Hudson MH, Ribeiro RC, Raimondi SC, Jeha S, Howard SC, Bhojwani D, Inaba H, Rubnitz JE, Metzger ML, Gruber TA, Coustan-Smith E, Downing JR, Leung WH, Relling MV, Evans WE. A revised definition for cure of childhood acute lymphoblastic leukemia. Leukemia 28(12):2336-43, 2014. doi: 10.1038/leu.2014.142 PMID: 24781017

Laszlo GS, Ries RE, Gudgeon CJ, Harrington KH, Alonzo TA, Gerbing RB, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB. High expression of suppressor of cytokine signaling-2 predicts poor outcome in pediatric Acute Myeloid Leukemia: A report from the Children’s Oncology Group. Leuk Lymphoma 55(12):2817-21, 2014. doi: 10.3109/10428194.2014.893305 PMID: 24559289

Bahrami A, Lee S, Caradine KD, Raimondi SC, Folpe AL. SMARCB1 deletion by a complex three-way chromosomal translocation in an extrarenal malignant rhabdoid tumor. Cancer Genet 207(9):437-40, 2014. doi: 10.1016/j.cancergen.2014.08.002 PMID: 25312828

Ostronoff F, Othus M, Gerbing RB, Loken MR, Raimondi SC, Hirsch BA, Lange BJ, Petersdorf S, Radich J, Appelbaum FR, Gamis AS, Alonzo TA, Meshinchi S. NUP98/NSD1 and FLT3-ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report. Blood 124(15):2400-7, 2014. doi: 10.1182/blood-2014-04-570929 PMID: 25145343

Gamis AS, Alonzo TA, Meshinchi S, Sung L, Gerbing RB, Raimondi SC, Hirsch BA, Kahwash SB, Heerema-McKenney A, Winter L, Glick K, Davies SM, Byron P, Smith FO, Aplenc R. Gemtuzumab Ozogamicin in children and adolescents with de novo acute myeloid leukemia (AML) improves event-free survival by reducing relapse risk – Results from the randomized Phase III Children’s Oncology Group trial, AAML0531. J Clin Oncol Sep 20; 32(27):3021-32, 2014. PMID: 25092781

Roberts KG, Pei D, Campana D, Payne-Turner D, Li Y, Cheng C, Sandlund JT, Jeha S, Easton J, Becksfort J, Zhang J, Coustan-Smith E, Raimondi SC, Leung WH, Relling MV, Evans WE, Downing JR, Mullighan CG, Pui CH. Outcome of children with BCR-ABL1-like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease. J Clin Oncol 32(27):3012-20, 2014. PMID: 25049327

Tarlock K, Alonzo TA, Moraleda PP, Gerbing RB, Raimondi SC, Hirsch BA, Ravindranath Y, Lange B, Woods WG, Gamis AS, Meshinchi S. Acute Myeloid Leukemia with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD Status: A report from the Children’s Oncology Group. Br J Haematol 166(2):254-9, 2014. doi: 10.1111/bjh.12852 PMID: 24661089

Jeha S, Coustan-Smith E, Pei D, Sandlund JT, Rubnitz JE, Howard SC, Inaba H, Bhojwani D, Metzger ML, Cheng C, Choi JK, Jacobsen J, Shurtleff SA, Raimondi S, Ribeiro RC, Pui CH, Campana D. Impact of tyrosine kinase inhibitors on minimal residual disease and outcome in childhood Philadelphia chromosome-positive acute lymphoblastic leukemia. Cancer 120(10):1514-1519, 2014. doi: 10.1002/cncr.28598 PMID: 24501014

Harrison CJ, Moorman AV, Schwab C, Carroll AJ, Raetz EA, Devidas M, Strehl S, Nebral K, Harbott J, Teigler-Schlegel A, Zimmermann M, Dastugue N, Baruchel A, Soulier J, Auclerc MF, Attarbaschi A, Mann G, Stark B, Cazzaniga G, Chilton L, Vandenberghe P, Forestier E, Haltrich I, Raimondi SC, Parihar M, Bourquin JP, Tchinda J, Haferlach C, Vora A, Hunger SP, Heerema NA, Haas OA. An international study of intrachromosomal amplification of chromosome 21 (iAMP21): cytogenetic characterization and outcome. Leukemia 28(5):1015-1021, 2014. doi: 10.1038/leu.2013.317

Sandahl JD, Coenen EA, Forestier E, Harbott J, Johansson B, Kerndrup G, Adachi S, Auvrignon A, Beverloo HB, Cayuela J-M, Chilton L, Fornerod M, de Haas V, Harrison CJ, Inaba H, Kaspers GJL, Liang D-C, Locatelli F, Masetti R, Perot C, Raimondi S, Reinhardt K, Tomizawa D, von Neuhoff N, Zecca M, Zwaan CM, van den Heuvel-Eibrink MM, Hasle H. t(6;9)(p22;q34)/DEK-NUP214 rearranged pediatric myeloid leukemia: an international study on 62 patients. Haematologica99(5):865-72, 2014. doi: 10.3324/haematol.2013.098517. Epub 2014 Jan 17. PMID: 24441146

Last update: June 2017