Long-term Effects Clinical Trials

Non-therapeutic protocols address such issues as side effects or long-term effects of therapy, quality of life, making testing easier on the children, prevention of pain, and issues related to nutrition and stress. There are also tissue and blood banking protocols for laboratory researchers who are studying diseases and searching for underlying causes and cures. The research at St. Jude is designed to include all aspects related to the care of sick children and their families.

ALLSTIM: Treatment for Executive Dysfunction in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Diseases Treated:

Supportive Studies: Long Term Effects: Childhood acute lymphoblastic leukemia

Eligibility:

 

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant is currently enrolled in SJLIFE.
  • Participant is greater than or equal to eighteen (18) years of age at time of evaluation.
  • Participant is not currently on stimulants or other medications intended to treat cognitive impairment.
  • Participant has full scale IQ greater than seventy-nine (79).
     

 

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BMTFU: Protocol for Collecting Long-Term Follow-Up Data on Recipients of Hematopoietic Stem Cell Transplant

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

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BRIGHT: Brain Integrity in Survivors of Hodgkin Lymphoma Treated with Thoracic Radiation

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant is currently enrolled in the St. Jude Life study and received chest radiation OR
  • Participant is a sibling, parent, relative or friend of a current or former St. Jude patient.
  • Participant is > 18 years of age at time of evaluation.
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CCSS: Childhood Cancer Survivor Study

Diseases Treated:

Childhood cancer incidence and survival

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Newly diagnosed with cancer between January 1, 1970, and December 31, 1996
  • Survival five years from diagnosis
  • Age less than 21 years at the time of diagnosis of cancer
  • English or Spanish speaking and living in the United States or Canada at the time of diagnosis
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FRAILTY: A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer

Diseases Treated:

Long-term effects of childhood cancer

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant is enrolled on the SJLIFE protocol
  • Participant completed a baseline SJLIFE assessment between 4 and 6 years prior to FRAILTY enrollment.
  • Participant’s age was between the ages of 18-45 when baseline SJLIFE assessment was completed.
  • Participant is not currently receiving treatment for cancer.
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LACOUT: Lactation Outcomes among Survivors of Pediatric Cancer

Eligibility:

This is a non-therapeutic clinical trial open to St. Jude patients only.

Participant is a St. Jude Life or ACT (After Completion of Therapy) patient.

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LDTAM: Low-Dose Tamoxifen Citrate in Reducing Breast Cancer Risk in Radiation-Induced Cancer Survivors

Diseases Treated:

For survivors of Hodgkin lymphoma

Eligibility:

  • Females, 25 years of age or older.
  • Participant does not plan to become pregnant in the next 2 years and is not currently breast feeding.
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NEULS: Risk of Psychopathology and Neurocognitive Impairment in Leukemia Survivors

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant was enrolled on SJCRH TOTXV ALL protocol (or Best Clinical Management that followed the same treatment provided in the TOTXV protocol)
  • Minimum of five years post diagnosis of ALL
  • Minimum age of 8.0 years at time of follow-up evaluation
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ONFUNC: Functional Outcomes For Children, Adolescents, and Young Adults With Osteonecrosis Following Hip Core Decompression

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant has a diagnosis of osteonecrosis and a hematologic malignancy or sickle cell disease.
  • Participant is a candidate for hip core decompression surgery.
  • Participant is 8 to 29 years of age.
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PREVENT: Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Congestive Heart Failure (PREVENT-CHF): A Phase IIB Randomized Placebo-Controlled Trial

Diseases Treated:

Congestive heart failure

Eligibility:

  • Participant is > 16 years of age.
  • Participant had cancer diagnosis < 21 years of age.
  • Participant has lifetime cumulative anthracycline dose > 300 mg/m2.
  • Participant is > 2 years since completion of treatment for cancer.
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PTSARC: Physical Therapy in Young Patients With Lower Extremity Malignancies Before Surgery

Diseases Treated:

Solid tumors

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Please see clinical trial for full inclusion and exclusion eligibility criteria.
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REPS: Impact of Resistance Training–Protein Supplementation on Lean Muscle Mass in Childhood Cancer Survivors

Diseases Treated:

Long-term effects of childhood cancer

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant is enrolled on the SJLIFE protocol.
  • Participant’s is 18 to 49 years of age and is 10 years post first cancer diagnosis and 
  • Participant lives within a 45-minute drive of a Greater Memphis Area ATC Fitness Center and speaks English
  • Participant does not have contra-indications to resistance training or protein supplementation and is not pregnant.
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SJLIFE: Establishment of a Lifetime Cohort of Adults Surviving Childhood Cancer

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • Participant was diagnosed with a childhood cancer which was treated or followed by St. Jude Children's Research Hospital
  • Participant completed treatment for disease at least ten years prior to entry in this study
  • Participant is willing to return to St. Jude for periodic evaluation
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SJLTFU: Protocol for Collecting Data on Childhood Cancer Survivors

Eligibility:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

  • All patients being followed or treated at St. Jude Children’s Research Hospital for the diagnosis of childhood cancer
  • Patient has not been permanently discharged from care and follow-up
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