PMVOC: Pain Management of Vaso-Occlusive Crisis in Children and Young Adults with Sickle Cell Disease


Sickle Cell Disease

Hematological Disorders

Phase I/II

Diseases Treated:

Sickle cell disease

Eligibility Overview:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.


Sickle cell pain is different for every patient. Some patients get complete relief from routine pain medicines, and others need more time or more doses of pain medicines before the pain goes away completely. There are many types of pain, including something called neuropathic pain. Neuropathic pain in other conditions (such as diabetes) has been treated successfully with a medicine called gabapentin. Doctors think that some sickle cell pain is a combination of pain types. Doctors would like to see if adding gabapentin to the usual pain medicines makes the pain go away faster or more completely.


  • Learn how much pain medicine is needed for sickle cell pain when patients also receive gabapentin.
  • Learn how the pain scores are different for patients who have gabapentin compared to pain medicine without gabapentin.

Eligibility criteria, among others, include:

  • Participant must be > 1 year and < 21 years.
  • Participant must have sickle cell disease.
  • Participant must be seeking care for acute vaso-occlusive pain at St. Jude Children’s Research Hospital.
  • Participant has adequate kidney function.

For the current eligibility status of this clinical study, referring physicians must contact St. Jude Children's Research Hospital at 1-866-2ST-JUDE (1-866-278-5833).

Principal Investigator

Doralina Anghelescu, MD

St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105  USA
Voice: 1-888-226-4343 or 901-595-4055
24-Hour Emergency Access Pager: 1-800-349-4334

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.