XPD12-077: Cognitive, Academic and Psychosocial Functioning in Long-Term Survivors of Pediatric Stem Cell Transplantation

Categories:

Psychology

Supportive Bone Marrow Transplant Studies

Eligibility Overview:

This is a non-therapeutic clinical trial that is only open to St. Jude patients.

Description

Advances in pediatric stem cell transplantation (SCT) have resulted in improved survival and prompted increased attention to the potential late side effects of this procedure. Past studies have shown generally stable cognitive (thinking) function in the first 5 years after transplant, with little evidence of significant problems. However, there has been almost no research done to study cognitive function long –term (> 5 years after transplant). In this study, researchers will evaluate large number long-term survivors of SCT using measures of intelligence, academic achievement, and specific cognitive functions such as attention, working memory and processing speed.

Researchers will also evaluate people who did not have SCT or other serious illnesses but are similar to the group of SCT survivors in age, gender and other factors. They will compare what they learned from both groups to see if they can understand more about the possible side effects of SCT on survivor’s thinking, learning abilities, and school performance.

Objectives

  • To evaluate the thinking and learning abilities in long-term SCT survivors.
  • To evaluate specific abilities, such as attention, memory, and speed processing information in long-term SCT survivors.
  • To evaluate psychosocial functioning and quality of life in long-term SCT survivors.

Eligibility

Inclusion Criteria for the participant:

  • Participant was treated with an allogeneic bone marrow or stem cell transplant at St. Jude.
  • Participant is < 21 years at time of transplant.
  • Participant is > 5 years from date of transplant.
  • Participant is currently > 8 years of age.
  • English is participant’s primary language.
  • Participant is routinely followed in Bone Marrow Transplant outpatient clinic.

Exclusion Criteria:

  • Participant has history of central nervous system (CNS) injury/disease predating or unrelated to reason for SCT.
  • Participant has history of major sensory or motor impairment that would preclude valid cognitive assessment.
  • Participant has history of transplant for metabolic storage disorder, osteogenesis imperfecta, osteopetrosis, or dyskeratosis congenital.
  • No major sensory or motor impairment that would preclude valid cognitive assessment. *
  • No history of specific CNS disease/ injury (e.g. Down Syndrome, traumatic brain injury). Does not exclude participants with mild cognitive impairments or special educational needs. *
  • No previous participation in BMTPE

Inclusion Criteria for the control (people who did not have SCT or other serious illnesses):

  • Participant is currently 8 years of age
  • Participant ‘s primary language is English
  • Participant has known has no known history of serious illness
  • Demographic match to a St. Jude SCT patient

Principal Investigator

Sean Phipps, PhD

St. Jude Children’s Research Hospital
262 Danny Thomas Place
Memphis, TN 38105  USA
Voice: 1-888-226-4343 or 901-595-4055
24-Hour Emergency Access Pager: 1-800-349-4334

Referring or consulting clinicians only: protocolinfo@stjude.org
For all other inquiries about St. Jude Children's Research Hospital studies: referralinfo@stjude.org

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.