This is a report of a single-blind randomized controlled trial to examine the long-term efficacy of a computerized cognitive training program designed at St. Jude Children’s Research Hospital to improve cognitive outcomes in childhood cancer survivors. Sixty-eight survivors of childhood acute lymphoblastic leukemia (ALL) or brain tumor (BT) were randomly assigned to computerized cognitive intervention (23 ALL/11 BT) or a waitlist control group (24 ALL/10 BT). Piecewise linear mixed-effect modeling was used to evaluate change over time in each group between baseline and immediate post-intervention/waitlist cognitive assessment and between immediate post-intervention and 6 months post-intervention/waitlist cognitive assessment for working memory, attention and processing speed. Cognitive benefits were maintained 6 months after the computerized cognitive training, indicating the clinical utility of this intervention.
Conklin HM, Ashford JM, Clark KN, Martin-Elbahesh K, Hardy KK, Merchant TE, Ogg RJ, Jeha S, Huang L, Zhang H. Long-term efficacy of computerized cognitive training among survivors of childhood cancer: a single-blind randomized controlled trial. Journal of Pediatric Psychology 42(2):220–231, 2017.