News Releases

Uforia unites media, artists and advocates for its annual Promesa y Esperanza® broadcast for St. Jude

In its 27th year, the St. Jude Promesa y Esperanza® (Promise and Hope) broadcast for St. Jude Children’s Research Hospital on Dec. 7 and 8 brought together media, musical artists and cancer advocates, raising more than $5.2 million.

Genetics predict type 2 diabetes risk and disparities in childhood cancer survivors

04/23/2024

Learn how ancestry changes genetic risk variants’ impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk.

Metabolic health before vaccination determines effectiveness of anti-flu response

04/18/2024

Poor metabolic health or dysfunction, not obesity, leads to poor anti-influenza immune responses. Learn about the new St. Jude influenza vaccination research.

Andrew Smith, MD, PhD, named chair of Diagnostic Imaging at St. Jude Children’s Research Hospital

04/15/2024

Andrew Smith, MD, PhD, named chair of Diagnostic Imaging at St. Jude Children's Research Hospital. Smith is an expert in the use of artificial intelligence in imaging and medicine.

New drug prevents flu-related inflammation and lung damage

04/10/2024

New RIPK3 inhibitor UH15-38 protected models against influenza-induced inflammation and lung injury. Learn how it selectively blocks pathogenic necroptosis.

St. Jude survivorship portal brings researchers ‘one-click’ away from discovery

04/09/2024

Learn about the survivorship portal, a part of the St. Jude Cloud ecosystem, and find out how researchers can use the portal to make new discoveries.

Targeting vulnerability in B-cell development leads to novel drug combination for leukemia

04/08/2024

Discover how a vulnerability in treatment resistant B-cell acute lymphoblastic leukemia (B-ALL) was uncovered by single-cell analysis of developmental stage.

Renowned St. Jude clinician and researcher to receive coveted award at AACR annual meeting

04/04/2024

St. Jude researchers to present their science at AACR annual meeting.

Study flips treatment paradigm in bilateral Wilms tumor, shows resistance to chemotherapy may point toward favorable outcomes

03/28/2024

See how chemotherapy resistance in bilateral Wilms tumor implies stromal predominant with favorable outcomes if surgery follows rather than further chemo or biopsy

Researchers turn back the clock on cancer cells to offer new treatment paradigm

03/27/2024

Rhabdoid tumor cells were reverted from a cancerous state to normal. Discover how deletion of quality control protein DCAF5 may treat an undruggable cancer.

Immunotherapy targeting cancer fusion protein may hold key to treating rare liver cancer

03/19/2024

Explore how a T-cell receptor targeting an oncogenic fusion holds treatment promise in fibrolamellar carcinoma (FLC), a rare liver cancer with poor prognosis.

Change in MYCN-driven cell state opens therapeutic window in high-risk neuroblastoma

03/19/2024

See how mesenchymal to adrenergic cell change mechanism in MYCN-linked neuroblastoma linked to high MYCN levels, driven by KDM4 induction.

Scientists find core regulatory circuit controlling identity of aggressive leukemia

03/19/2024

Anaplastic large cell lymphoma is an aggressive form of cancer. Learn how a core regulatory circuit & STAT3 in ALCL may lead to new therapeutic opportunities.

Role in mitochondrial metabolism paints more complete picture of MCL-1 function

03/18/2024

See how anti-apoptosis oncoprotein MCL-1 also functions in fatty acid metabolism by binding ACSL1 explaining cardiac toxicity in clinical trials

Rare inflammatory disease responds best to double inhibition

03/06/2024

Ruxolitinib treats hemophagocytic lymphohistiocytosis (HLH) models better than JAK1 or 2 single inhibitors. Discover its promise in an ongoing clinical trial.

St. Jude taps health care start-up veteran as first Senior Vice President of Tech Commercialization

02/20/2024

New VP will work with St. Jude researchers to commercialize discoveries made at St. Jude to benefit more patients.

Novel bispecific design improves CAR T–cell immunotherapy for childhood leukemia

02/12/2024

Learn why bispecific chimeric antigen receptor (CAR) T-cell therapy for acute myeloid leukemia (AML) improved treatment, confirmed by artificial intelligence.

Sara Federico, MD, named director of the Solid Tumor Division at St. Jude Children’s Research Hospital

02/07/2024

Established clinician researcher will focus on novel treatments and clinical trials for difficult-to-treat childhood cancers.

Inaugural class of Damon Runyon– St. Jude Pediatric Cancer Research Fellows announced

02/01/2024

This initiative supports early-career scientists studying pediatric cancer, addressing a funding gap between pediatric and adult cancer research.

St. Jude Children’s Research Hospital adds $13 million project to Research Collaboratives Program

01/18/2024

Created as part of the 2022-2027 Strategic Plan, the St. Jude Research Collaboratives program is part of an overall effort by the institution to fund collaborative research addressing complex scientific problems with transformative potential for the diseases treated at St. Jude.

Molecular ‘super-glue’ shows promise of cancer drug discovery platform

01/16/2024

Learn how St. Jude created a molecular super-glue to target cancer-related protein casein kinase 1 alpha (CK1α) & how the platform may lead to new treatments.

St. Jude Home Care, LLC is first U.S. pediatric home health agency to earn new category of industry certification

01/16/2024

The mobile service was certified by CHAP in pediatrics and home health.

HOXA9 tracking reveals RBM5 dual function and therapeutic potential for acute myeloid leukemia

01/12/2024

See how St. Jude researchers use CRISPR-Cas9 to identify RBM5 as a key play in HOXA9-associated leukemia and how RBM5 was shown to have a duel function as splicing factor and transcription factor.

Two common biomarkers predict heart risk in asymptomatic childhood cancer survivors

01/11/2024

Find how global longitudinal strain (GLS) & N-terminal-pro-B-type natriuretic peptide (NT-proBNP) improved heart risk predictions in pediatric cancer survivors.

Updated genomic landscape for pediatric acute myeloid leukemia enables new treatment possibilities

01/11/2024

Scientists at St. Jude Children’s Research Hospital refined and enhanced the classification system for a type of pediatric leukemia using genomic and transcriptomic analysis.

Acute pediatric critical illness definition enables global research

01/08/2024

Find how a new more inclusive consensus definition of acute pediatric critical illness will fuel research across the globe due to St. Jude-led collaboration.

A new approach can address antibiotic resistance to Mycobacterium abscessus

01/05/2024

Learn how St. Jude scientists developed a new form of spectinomycin, which overcomes efflux and thus antibiotic resistance in Mycobacterium abscessus.

Elusive cytonemes guide neural development, provide signaling ‘express route’

01/02/2024

Discover the first images of cytonemes during mammalian neural development, serving as express routes to establish morphogen gradients and tissue patterning.

Structures of Parkinson’s disease-linked proteins offer a framework for understanding how they work together

12/21/2023

See how researchers at St. Jude Children’s Research Hospital used cryo-electron microscopy to solve structures of the LRRK2/Rab29 complex, showing potential routes for drug treatment against Parkinson’s disease

GPCR structure: Research reveals molecular origins of function for a key drug target

12/21/2023

St. Jude researcher Madan Babu with Brian Kobilka, Michel Bouvier, and Franziska Heidenreich probe the individual contribution of each amino acid in G-protein coupled receptor which binds adrenaline to expand understanding of top drug target

Unraveling predisposition in bilateral Wilms tumor

12/18/2023

Learn how scientists at St. Jude gained new understanding of the genomic events that predispose children to bilateral Wilms tumor, cancer in both kidneys.

Prediabetes treatment may reduce heart and kidney risks in childhood cancer survivors

12/13/2023

Childhood cancer survivors have a higher prevalence of prediabetes & diabetes than peers. Learn how treating these conditions may protect heart & kidney health.

James R. Downing, MD, recognized as one of Modern Healthcare’s 100 Most Influential People for the second consecutive year

12/02/2023

James R. Downing, MD, listed as one of 100 influential people in healthcare in 2023.

Modular chimeric cytokine receptors improve CAR T–cell therapy for solid tumors

11/30/2023

Adding a modular chimeric cytokine receptor to CAR T cells increased their efficacy. Learn how this modular system could improve brain and solid tumor therapy.

St. Jude revealed functional targets of oncogenic HOXA9 in high-risk pediatric leukemia

11/28/2023

St. Jude scientists identified 229 genes regulated by undruggable oncogenic HOXA9. Learn how it may lead to better treatments for high risk pediatric leukemias.

Promising target for CAR T Cells helps cancer trick the immune system

11/21/2023

GRP78 is a promising CAR T-cell immunotherapy target for brain and solid tumors. Discover why it’s special, including how cancer uses it to trick immune cells.

Robust chromatin map explains heterogeneity of pediatric acute lymphoblastic leukemia

11/20/2023

Find how mapping chromatin accessibility & regulation in pediatric acute lymphoblastic leukemia (ALL) subtypes may uncover therapy response heterogeneity cause.

St. Jude scientists identify T-cell differentiation nodes to improve cancer-killing

11/15/2023

Discover how T-cell differentiation nodes can be promoted or blocked to improve immunotherapy anticancer efficacy according to new T-cell exhaustion research.

Fusion oncoprotein forces cell fates toward rhabdomyosarcoma

11/15/2023

Fusion positive pediatric rhabdomyosarcoma (RBD) can come from non-muscle cells with a fusion oncoprotein. Find how the St. Jude discovery may change treatment.

‘Highly cited’ St. Jude scientists named to annual list

11/15/2023

Learn more about the St. Jude scientists who are among the most highly cited researchers in the world, a distinction that reflects the value of their work among other investigators.

St. Jude Thanks and Giving campaign celebrates 20th anniversary

11/13/2023

The St. Jude Thanks and Giving® campaign is celebrating 20 years of bringing together celebrities, businesses and consumers to support St. Jude Children’s Research Hospital.

Romero Britto, Pamela Silva, Maity Interiano, Adrianne Calvo celebrate 20 years of St. Jude Thanks and Giving® campaign at star-studded Miami event

11/13/2023

Romero Britto, Pamela Silva, Maity Interiano, Adrianne Calvo and others came together for an evening of festivities at Britto Palace to celebrate the 20th anniversary of the St. Jude Thanks and Giving® campaign.

Emma Roberts, Santa J Claus, and influencers unite for Giving Tuesday to support St. Jude Children’s Research Hospital

11/13/2023

This Giving Tuesday, join celebrities like Emma Roberts, content creators like Santa J Claus and communities everywhere to raise funds for St. Jude Children’s Research Hospital® and their lifesaving mission.

St. Jude Children’s Research Hospital and TelevisaUnivision score big with first Spanish language charity spot for St. Jude to air during Sunday’s big game

11/13/2023

Thanks to a partnership between St. Jude and TelevisaUnivision, viewers will get a glimpse of the confetti that streams at one of the most joyous moments for St. Jude families in Univision's first charity advertising spot during Sunday’s big game.

"Run Rich Run" celebrates 20 years: 20th run benefiting St. Jude Children’s Research Hospital to air during NFL Network’s 2024 NFL Draft coverage

11/13/2023

Run Rich Run, the charitable campaign to raise awareness and support for St. Jude Children’s Research Hospital, celebrates its 20th year with Rich Eisen's run airing during the NFL Network's 2024 NFL Draft coverage.

Giles Robinson, M.D., named director of the Neuro-Oncology Division at St. Jude Children’s Research Hospital

11/07/2023

Dr. Robinson is now also co-leader of the Neurobiology and Brain Tumor Program in the St. Jude Comprehensive Cancer Center.

Scientists reveal structures of neurotransmitter transporter

11/01/2023

See how researchers at St. Jude Children’s Research Hospital used cryo-electron microscopy to solve structures of a neurotransmitter (dopamine, serotonin) transporter VMAT2 responsible for packing vesicles in neurons for signaling.

Latin media, artists, content creators unite at Promesa y Esperanza seminar to support St. Jude Children’s Research Hospital

10/24/2023

More than 250 attendees spanning Spanish-language media, celebrities and content creators gathered last weekend for the St. Jude Promesa y Esperanza seminar.

St. Jude Children’s Research Hospital, ALSAC announce new board leaders

10/16/2023

The boards of St. Jude and ALSAC have new chairs and vice-chairs who will oversee the bold commitments of the ongoing strategic plan.

St. Jude Children’s Research Hospital named in Fast Company’s annual list of Brands That Matter

10/12/2023

St. Jude is among the top brands engaging communities through culturally relevant and meaningful outreach.

3D genome architecture influences SCID-X1 gene therapy success

10/06/2023

Lentiviral gene therapy for X-linked severe combined immunodeficiency disorder (SCID-X1) is safe. Discover how 3D DNA structure explains biology & safety.

A pep in their step: Local school district makes strides for kids everywhere at St. Jude Walk/Run Memphis

10/03/2023

More than 3,500 participants gathered at Tom Lee Park for the 9th annual St. Jude Walk/Run Memphis, held on the final day of Childhood Cancer Awareness Month.

Genetics help explain childhood cancer survivors’ mortality risk from a second cancer

10/02/2023

Childhood cancer survivors are at higher risk for second cancer & associated mortality. Find how genetic variants increase risk & can be used to protect health.

Art meets athletics in celebration of African American achievement at St. Jude Spirit of the Dream

10/02/2023

Artist Derek Fordjour and Grizzlies head coach Lionel Hollins were honored for their pioneering work and philanthropy with the Spirit of the Dream Award.

Predicting phase separation of cancer-causing fusion oncoproteins with machine learning

09/28/2023

See how machine learning was used to gain insight into condensation behavior and oncogenic mechanisms of fusion oncoproteins.

St. Jude Children’s Research Hospital Unveils The Domino’s Village

09/27/2023

St. Jude partners with Domino's to build a six-story building for patients and families. The multimillion-dollar housing facility is part of Domino's 10-year commitment to St. Jude.

St. Jude refines definition and hones treatment of hyperdiploid leukemia

09/20/2023

Hyperdiploid B-cell acute lymphoblastic leukemia has evaded a consensus definition. Find the definitions that best correlated with better patient outcomes.

Specialized T cells in the brain slow progression of Alzheimer’s disease

09/07/2023

T cells can slow Alzheimer’s disease progression in a model system. Find how the neuro-immune study may be the future of neurodegenerative disease research.

St. Jude Children’s Research Hospital announces more than $50 million in funding for employee-generated transformational projects

08/30/2023

St. Jude has announced funding for employee-generated ideas. Find out about the approved projects

St. Jude shows cancer resistance protein can have its cake and eat it too

08/18/2023

See how one protein responsible for chemotherapy resistance functions and how we can prevent future drug resistance to improve treatment

St. Jude Memphis Marathon Weekend unveils refreshed courses for 2023

08/17/2023

The new race courses take participants on a scenic journey through the heart of Memphis to support the lifesaving mission of St. Jude.

Immune cells present long before infection predict flu symptoms

08/17/2023

Who will get sick from influenza infection has long been a mystery. Learn how immune cells may predict susceptibility to symptoms long before flu infection.

Philanthropy takes the main stage during St. Jude JAM, raising more than $1 million to benefit St. Jude Children’s Research Hospital®

08/10/2023

The annual FedEx pilot car build has surpassed the $1 million lifetime total raised in support of research and treatment by St. Jude.

Five facts about philanthropy during the 2023 FedEx St. Jude Championship

08/09/2023

The 2023 FedEx St. Jude Championship officially kicks off the FedEx Cup on Aug. 10. This PGA TOUR stop has raised more than $66 million for St. Jude since 1970.

Celebrating art for a cause: St. Jude Children’s Research Hospital patient artwork featured during 2023 FedEx St. Jude Championship, available in fan shop and charity auction

08/07/2023

Patient art will be featured throughout the FESJC Aug. 10-13 at TPC Southwind. This year’s featured artwork is by St. Jude patients Maelin-Kate and Bridget.

St. Jude names Sarah Currie chief nursing executive and senior vice president

08/07/2023

Award-winning NICU expert spent 21 years at Children’s Wisconsin, 4 years as executive director of perinatal/ neonatal services.

Five Local Builders Unite to Construct Five Homes benefiting St. Jude Children’s Research Hospital®

08/01/2023

Dallas/Fort Worth builders collaborate for good as they construct homes for the lifesaving mission of St. Jude.

Mutation accessibility fuels influenza evolution

07/28/2023

See how a new model developed by St. Jude scientists looking at influenza evolution can predict future virus mutations.

Jinghui Zhang, PhD, elected Fellow of the International Society for Computational Biology

07/27/2023

Zhang is one of 15 other scientists being honored by ISCB in 2023.

Pediatric Early Warning Systems save lives in Latin American hospitals

07/08/2023

Learn how Pediatric Early Warning Systems save the lives of children with cancer in Latin America by identifying early when they are in need of supportive care.

Pediatric hepatoblastoma model hints at DNA damage repair pathway for novel therapeutics

07/07/2023

See how creating a new research model to study hepatoblastoma (liver cancer) gave St. Jude scientists clues into potential therapeutic targets

Immune and tumor cell “tug-of-war” controls anti-cancer activity

07/05/2023

Cancer cells & the immune cells that activate the anti-cancer response compete over the nutrient glutamine. Discover how it may improve cancer therapies.

From blackboard to mortarboard: 23 scholars from 13 countries graduate from ALSAC Global Scholars Program

07/03/2023

This comprehensive education program provides nonprofits worldwide with a solid foundation to grow sustainable revenue.

Base editing shows potential superiority for curing sickle cell disease

07/03/2023

Adenosine base editing restarted fetal hemoglobin expression in cells from patients with sickle cell disease. Find how St. Jude & Broad are advancing to a cure.

White Cap, DEWALT launch co-branded car, St. Jude patient art-inspired helmet, donate $125,000 to St. Jude Children’s Research Hospital

06/29/2023

The two brands revealed a special No. 20 car on June 25 for the ALLY 400 at Nashville Superspeedway highlighting their philanthropic partnership for St. Jude.

Honoring a patron painter and charitable NBA coach at St. Jude Spirit of the Dream

06/28/2023

From the canvas to the court, two philanthropists with Memphis ties honored for outstanding achievements in advancing the lifesaving mission of St. Jude.

St. Jude in top five of elite ranking of hospitals treating children with cancer

06/21/2023

The U.S. News Best Children’s Hospitals for Cancer rankings rely on clinical data and on an annual survey of pediatric specialists.

Biostatistician Deo Kumar Srivastava, Ph.D., named ASA fellow

06/20/2023

He is being recognized by the American Statistical Association for his leadership role in numerous St. Jude survivorship studies.

St. Jude Children’s Research Hospital Marks World Sickle Cell Day with New Award and Campus Exhibit

06/14/2023

A new exhibit will be displayed on St. Jude campus at the Danny Thomas/ALSAC Pavilion, showcasing the work of the late Dr. Rudolph Jackson.

Victor J. Torres, Ph.D., named chair of newly formed Department of Host-Microbe Interactions at St. Jude Children’s Research Hospital

06/12/2023

Dr. Victor J. Torres is leading a newly-formed department called the St. Jude Department of Host-Microbe Interactions, which will focus on treating and preventing disease-causing infections in children.

Damon Runyon launches new pediatric cancer fellowship in partnership with St. Jude Children’s Research Hospital

06/08/2023

$9 million initiative addresses shortage of top young scientists entering pediatric cancer research careers.

St. Jude Children’s Research Hospital featured on episode two of new FOX television series Gordon Ramsay’s Food Stars

06/02/2023

Competition contestants were challenged to host their very own gala to benefit St. Jude.

Ready, Set, Register: Sign up now for St. Jude Memphis Marathon Weekend

06/01/2023

Now is the time to register for the St. Jude Memphis Marathon® Weekend presented by Juice Plus+, happening Saturday, Dec. 2, 2023.

St. Jude finds NLRP12 as a new drug target for infection, inflammation and hemolytic diseases

06/01/2023

NLRP12 bridges hemolysis, inflammation and multi-organ damage. Learn how this ‘on’ switch for innate immune cell death could be a drug target to prevent pathology.

Genetic change increased bird flu severity during U.S. spread

05/30/2023

Find how H5N1 avian influenza viruses increased disease-causing abilities & gained the capability to enter mammalian brains as they spread west across North America.

SWI/SNF complexes “bookmark” cell identity during division

05/24/2023

Read about how Scientists at St. Jude determined how the SWI/SNF chromatin remodeling complex helps cancer cells remember how to be cancerous after division.

Epigenetic landscape modulates pioneer transcription factor binding

05/24/2023

St. Jude scientists are studying how pioneer transcription factors access tightly wound DNA. Learn about how their findings may impact therapeutic development.

Capturing transporter structure paves the way for drug development

05/23/2023

Learn how St. Jude scientists captured six new structures of the Spns2 transporter, providing insights to aid therapeutic design for cancer and other diseases.

St. Jude scientist M. Madan Babu elected to the Royal Society of London

05/10/2023

Director of the St. Jude Center of Excellence for Data-Driven Discovery named a fellow of the 360-year-old British scientific organization.

St. Jude Children’s Research Hospital and iHeartCountry Celebrate 10-Year partnership

05/08/2023

iHeartMedia and the country music community have helped raise more than $157 million for St. Jude kids and families since 1989.

St. Jude tool gets more out of multi-omics data

05/04/2023

NetBID2 finds hidden drivers by extracting more from multi-omics data. Learn how the computational tool can find druggable targets in cancer and other diseases.

Run Rich Run: 40 Yards Closer to Helping 400,000 Kids Around the World, St. Jude Patient Runs 4.7 second 40-Yard-Dash to Benefit St. Jude Children’s Research Hospital

05/01/2023

NFL Network host Rich Eisen suited up and sprinted for St. Jude Children’s Research Hospital this week during his annual Run Rich Run event.

Study shines light on impact of environment on neurocognitive outcomes

04/28/2023

Find how the neighborhood economic hardship index predicts baseline and long-term outcomes in pediatric brain tumor patients treated with radiation therapy.

Why did the Polaris Dawn crew land in the Philippines this week? 5 answers.

04/21/2023

Polaris Dawn crew donates Starlinks to organizations in Philippines, Chile, Peru, Brazil and Mozambique to improve access to global healthcare

Clinical trial improves neurocognitive outcomes for childhood craniopharyngioma

04/18/2023

Proton therapy for craniopharyngioma had better neurocognitive than & similar survival outcomes as historical photon therapy. Read the phase 2 clinical trial.

Prime editing shows proof of concept for treating sickle cell disease

04/17/2023

Genomic prime editing, a new DNA-changing technology, fixed sickle cell disease mutations in patient cells. Learn how it could lead to cure for genetic anemias.

St. Jude scientists to receive coveted awards at AACR annual meeting

04/11/2023

Two St. Jude investigators will receive awards at the 2023 AACR meeting. Learn about their careers & the science they & their St. Jude peers will be sharing.

Combination therapy overcomes BET inhibitor resistance

04/10/2023

St. Jude scientists found that combination of BET and GSK3 inhibitors can overcome treatment resistance in a type of childhood leukemia. Read about the study.

Healthy lifestyle associated with reduced mortality risk in childhood cancer survivors

04/05/2023

A report from the Childhood Cancer Survivor Study (CCSS) provides strong evidence of the importance of a healthy lifestyle for adults who were treated for cancer as children

Humans vs. Bacteria: Differences in Ribosome Decoding Revealed

04/05/2023

St. Jude scientists found that human ribosomes decode mRNA slower but more accurately than bacteria. Read about the study’s implications for drug development.